rrust.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

"Authentic" #hiPSC-derived #Pericyte 😎 Sharing highly similar proteome/phosphoproteome to primary👤🧠cortical pericyte Contractile ⏫ #BloodBrainBarrier & Neuroprotective (Pdgfrb F7/F7🐭) Clear Aβ Tau (🧠slices 5xFAD🐭 APOE4 P3001S🐭) @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

submitted 17 days ago • 0 comments

#hiPSC derived #Pericyte 👉>80% Home to & >50% Arborize on Capillaries in live🧠slice of PdgfrbF7/F7🐭 in situ PDGFBB-PDGFRβ PLA assay😍 👉⏫Amyloidβ clearance on 10-m/o 5xFAD 🐭🧠slice Are these phagocytic pericytes still vessel-bound?😁 @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

submitted 24 days ago • 0 comments

In @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...

submitted 27 days ago • 3 comments

#Medsky🧪 #Neurosky Much of stroke research focuses on acute injury - but what changes in the brain one month after stroke? By @rrust.bsky.social et l link.springer.com/article/10.1... www.researchhub.com/paper/938498...

submitted 30 days ago • 0 comments

Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma. Wonder if these NSCs exist in humans & can show similar therapeutic potential www.nature.com/articles/s41...

submitted 38 days ago • 0 comments

New preprint🚨 We generated human brain pericytes from pluripotent stem cells. They show strong molecular & functional similarities to primary human brain pericytes Transplanted into pericyte-deficient mice, they formed hybrid human-mouse microvessels🐭 biorxiv.org/content/10.1...

submitted 38 days ago • 1 comment

Dynamic structural connectivity changes in cortical and cortico-striatal strokes in mice https://www.biorxiv.org/content/10.1101/2025.03.27.644898v1

submitted 51 days ago • 0 comments

A new review from our lab exploring how the blood-brain barrier (BBB) can be used as a treatment target for neurodegenerative disorders tandfonline.com/doi/10.1080/... TL;DR → Here are a few key highlights 👇

submitted 55 days ago • 1 comment

Here's a very cool paper from @biorxiv-biophys.bsky.social I shared on ResearchHub this week. The authors designed a three-legged motor protein that can walk down DNA in either direction. www.researchhub.com/paper/930685... 🧪 @researchhubf.bsky.social

submitted 62 days ago • 3 comments

Optimize the time window for cell therapy for #Stroke Photothrombosis Rag2-/-🐭 hiPSC-#NeuralProgenitorCell intracerebral injection 7 days (vs 1 d) post injury➡️ ⏫NPC proliferation ~20-fold⏫survival by 7-wk dpi👍 @rrust.bsky.social bioRxiv 2025 www.biorxiv.org/content/10.1...

submitted 75 days ago • 0 comments

Do our genes sabotage our bodies? @haoyin.bsky.social reviewed a bioRxiv paper that suggests a special gene helps melanoma (a type of skin cancer) grow and evade the immune system. 🧵1/7

submitted 76 days ago • 1 comment

Nice roundup on CRISPR genome editing @economist.com www.economist.com/leaders/2025...

submitted 81 days ago • 3 comments

#Medsky🧪 #IDsky #Immunosky #publichealth the study showed that rising self-antigen levels during infection give self-reactive #Tcells an opportunity for enhanced TCR signalling. Regulatory T cells of matched specificity counteract this that’s preventing autoimmunity. www.science.org/doi/10.1126/...

submitted 81 days ago • 1 comment

Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...

submitted 87 days ago • 1 comment

New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...

submitted 87 days ago • 0 comments

#Medsky🧪 #IDsky #immunosky #neurosky This study shows that delayed intracerebral transplantation of neural progenitor cells (NPCs) derived from human induced pluripotent cells (iPSCs) at 7 days post #stroke significantly enhances graft proliferation and survival…

submitted 89 days ago • 0 comments

Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️ Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold. www.biorxiv.org/content/10.1...

submitted 90 days ago • 1 comment

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

submitted 100 days ago • 267 comments

Glomerular Neovascularization #DiabeticKidneyDisease #CaseReport #SpatialTranscriptomics #Visium @10xGenomics 50-μm section multiplex IF TEM▶️⏫Periglomerular Capillaries + de novo vascular anastomosis crossing Bowmen capsule #KPMProject #CJASN 2024 journals.lww.com/cjasn/abstra...

submitted 103 days ago • 0 comments

Thank you @castltrastondrs.bsky.social for highlighting our work!

submitted 103 days ago • 1 comment

Cool work!

submitted 105 days ago • 1 comment

Zenodo vs Open Science Framework

submitted 108 days ago • 0 comments

New study led by @cathnaledi.bsky.social showing that physical exercise improves #cerebrovascular function in mice with genetic risk for Alzheimer’s disease.

submitted 106 days ago • 0 comments

www.nature.com/articles/s41...

submitted 107 days ago • 0 comments

DeepSeek R1 is making headlines in the news and is being compared to OpenAI's o1. However, many have not read the preprint. We invite you to evaluate the DeepSeek R1 preprint at @researchhubf.bsky.social , and reward high-quality contributions with 150$ (in RSC). researchhub.com/paper/916140...

submitted 111 days ago • 0 comments

papers.ssrn.com/sol3/papers.... #cerebrovascular

submitted 112 days ago • 0 comments

Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.

submitted 113 days ago • 31 comments

Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels https://www.biorxiv.org/content/10.1101/2025.01.08.631889v1

submitted 128 days ago • 0 comments

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations https://www.biorxiv.org/content/10.1101/2025.01.08.631962v1

submitted 129 days ago • 0 comments