1. Thrilled to share in bluesky an exciting discovery by Chao Wang in the lab: Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9 #glycotime https://www.biorxiv.org/content/10.1101/2024.10.11.617879v1
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2. Using SuFEx #clickchemistry, Chao developed a ligand with exclusive specificity towards Siglec-7/-9 and converted it into a degrader that targets both Siglecs simultaneously to the lysosome for degradation.
3. This is a complementary approach to the antibody-sialidase conjugates developed @carolynbertozzi.bsky.social
and BiTE-sialidase developed by our own lab.
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and BiTE-sialidase developed by our own lab.