Profile avatar
pengwu.bsky.social
Professor at Scripps Research. Interested in glycosylation, cancer immunology, and autoimmunity.
34 posts 859 followers 287 following
Prolific Poster
Conversation Starter
Posts 40 Comments 10

Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social

submitted 6 days ago • 1 comment

www.theatlantic.com/health/archi...

submitted 6 days ago • 0 comments

If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus? www.nytimes.com/2025/02/14/o...

submitted 11 days ago • 0 comments

Look forward to speak at the 2025 Carbohydrate GRC #glycotime

submitted 11 days ago • 0 comments

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

submitted 17 days ago • 60 comments

Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime

submitted 22 days ago • 0 comments

Happy Chinese new year!

submitted 28 days ago • 0 comments

Siglec binding to sulfated glycan @siglecdude.bsky.social #glycotine. Thanks for including us in this fantastic work.

submitted 34 days ago • 0 comments

#WeekendRead! #EveryOrganIsAnImmuneOrgan 😉! The Balachandran lab &co show @ Nature that the alarmin domain of IL33 expands lymphoneogenic ILC2s which favor tertiary lymphoid organ formation in colitis & during tumor growth! Engineered IL33 can be an antitumoral! www.nature.com/articles/s41...

submitted 38 days ago • 0 comments

Aging is accompanied by a down-regulation of the bisected glycan and an up-regulation of the digalactosylated glycan on IgG #glycotime

submitted 38 days ago • 1 comment

Polysialic acids are upregulated on activated T cells #glycotime

submitted 40 days ago • 0 comments

A geometric deep learning tool by Marchand et al. designs protein binders on small-molecule “neosurfaces,” yielding switchable interactions. Validated on three drug-bound proteins, it unlocks new ways to regulate protein function, paving the way for future therapies. www.nature.com/articles/s41...

submitted 40 days ago • 0 comments

So happy to see the final version of our paper "Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell Therapy" online #immunotherapy

submitted 43 days ago • 0 comments

Check this out, sialic acid can be used as an auxiliary and protecting group for ganglioside synthesis #glycotime

submitted 47 days ago • 0 comments

“Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface” www.nature.com/articles/s43...

submitted 60 days ago • 1 comment

Hot off the press 🔥 Very proud of this collaboration! 💫 @Harvard @JohnsHopkins @UChicago @UniHeidelberg Interested in immunotherapy-induced toxicity? 🤓 This is a must-read 🤩 #immunology #science #cancer #research @nct-heidelberg.bsky.social @dkfz.bsky.social www.cell.com/trends/immun...

submitted 60 days ago • 1 comment

Expanding T cells in the presence of mannose can generate T cells with progenitor like properties www.cell.com/cancer-cell/...

submitted 69 days ago • 0 comments

New peptide-driven proton sponge nano-assembly invented by the Jokerst lab @ucsd induces cancer cell death via the lysosome rupturing-regulated pyroptosis and necroptosis. Thanks for including us in this amazing study!

submitted 76 days ago • 0 comments

A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy https://www.biorxiv.org/content/10.1101/2024.12.05.627079v1

submitted 77 days ago • 0 comments

#IDSky

submitted 78 days ago • 4 comments

New work with Yi @berkeleylab Terrific collaboration over 14 years, from the development of biocompatible click chemistry to AI assisted polysulfate design for engergy storage #polymer

submitted 81 days ago • 0 comments

By activating dendritic cells to produce IL-12 and IFN-γ, agonistic anti-CD40 converts Tregs into Type 1 effector cells

submitted 82 days ago • 0 comments

Gingerbread house decoration contest at the NIH

submitted 83 days ago • 0 comments

A rapid de novo binder design platform leveraging generative models, including RFdiffusion, ProteinMPNN, and AlphaFold2, to engineer minibinders targeting the cancer-associated pMHC complex, NY-ESO-1(157-165)/HLA-A*02:01 www.biorxiv.org/content/10.1...

submitted 85 days ago • 0 comments

"Vaccinating" people against misinformation by giving them small doses in advance is effective www.science.org/content/arti...

submitted 85 days ago • 0 comments

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

submitted 86 days ago • 9 comments

This is a fantastic use of Bioorthogonal chemistry and #clickchemistry to assemble multi-specific engagers to recruit different types of immune cells for #cancerimmunotherapy www.cell.com/cell/fulltex...

submitted 88 days ago • 0 comments

Re-reading your rejected manuscript

submitted 88 days ago • 3 comments

www.biorxiv.org/content/10.1...

submitted 88 days ago • 1 comment

Dual-ligase PROTACs: a novel approach for enhancing TPD. By recruiting two distinct E3 ligases within a single molecule, we amplify degradation efficacy & potentially mitigate resistance occurrence. Great collabo with the Ciulli lab & friends at Promega. pubs.acs.org/doi/10.1021/...

submitted 90 days ago • 1 comment

This is an outstanding review discussing the challenges of CAR-T for the treatment of solid tumors. One big hurdle is limited trafficking to the tumor bed. #immunotherapy www.nature.com/articles/s41...

submitted 91 days ago • 0 comments

The place to be

submitted 91 days ago • 0 comments

The absolute best post of the day, possibly of the entire month! This public atlas came online to relate disease to protein levels found in the blood from thousands of people across many diseases, searchable by sex. 1/9 bsky.app/profile/chil...

submitted 94 days ago • 4 comments

1. Thrilled to share in bluesky an exciting discovery by Chao Wang in the lab: Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9 #glycotime www.biorxiv.org/content/10.1...

submitted 92 days ago • 1 comment

Such a great pleasure to visit Weige school at Taipei again to discuss the applications of #clickchemistry

submitted 93 days ago • 0 comments

Had great time to attend the SMART symposium in protein degradation and catch up with old friends🎉💐

submitted 93 days ago • 0 comments

When I went to the @yaleuniversity.bsky.social #chembio retreat, I got this cool #glycotime shirt. I showed it to Yale alum @ssmelyansky.bsky.social. The response: “That’s so cool that they used the B. subtilis glycocalyx!” Wow. People in @kiesslinglab.bsky.social recognize cells via their glycans.

submitted 93 days ago • 2 comments

With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...

submitted 93 days ago • 0 comments

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

submitted 95 days ago • 45 comments

This is a terrific tool to evolve antibodies. Works perfectly for us. www.nature.com/articles/s41...

submitted 99 days ago • 0 comments