#slidearchiveseries SMARCB1 deficient renal medullary carcinoma
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
#gupath #pathsky #pathoutpic
🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation
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Comments
🔬reticular, cribriform, and cord-like patterns; intratumoral inflammatory infiltrate (sometimes abscess forming); fibrotic stroma with myxoid areas
✨ metastasis common to lung, liver, LN, adrenal gland, RP, etc #gupath #pathsky #pathoutpic