🧠Our new study in Cephalalgia (https://journals.sagepub.com/doi/10.1177/03331024241306103) explores genetic variants in FHM1-3 genes using @ukbiobank.bsky.social data.
A genotype-first approach revealed that these 🧬variants ⬆️ #migraine risk—and surprisingly, a link to ⬇️ #epilepsy was discovered.
Here’s what we found🧵
A genotype-first approach revealed that these 🧬variants ⬆️ #migraine risk—and surprisingly, a link to ⬇️ #epilepsy was discovered.
Here’s what we found🧵
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đź’ˇ Carriers were compared with non-carriers in a burden analysis.
đź’ˇ A machine learning-based approach (#LoGoFunc) was used to predict whether variants resulted in gain-of-function, loss-of-function or neutral effect
⚡️These changes may lead to a more depolarized cell membrane potential 🧠!
#PersonalizedMedicine.