chrstaehr.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🇦🇺🦘Just wrapped up 6 incredible weeks of science, collaboration at the University of the Sunshine Coast. Thanks to Vicki Hinkley for such a productive partnership—I’m excited to continue this collaboration across 🇩🇰 and 🇦🇺. I’m also grateful to the USC CONNECT Programme for the funding 🙏

submitted 1 day ago • 0 comments

🦒🫀Measuring hemodynamics in awake giraffes sounds like a wild challenge 🤯. New paper by Christian Aalkjaer et al in @actaphysiologica.bsky.social 🔓: onlinelibrary.wiley.com/doi/full/10.... 🦒 While drinking🚰: ⬇️ Heart rate ➡️ Arterial blood pressure ➡️ Carotid blood flow ⬆️ CSF pressure 🧠

submitted 13 days ago • 1 comment

Come join us at the Bioinformatics Research Centre at Aarhus University. Tenure track/associate professor position available with application deadline June 1, 2025. Application details here: international.au.dk/about/profil...

submitted 13 days ago • 0 comments

Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu

submitted 59 days ago • 0 comments

Amazing work out by Hirase Lab 🤩

submitted 59 days ago • 0 comments

Oral Glycine supplementation (DT-109 Gly-Gly-Leu) ⏬#Atherosclerosis & lesional #Calcification in ♂️Monkeys A potential role of Glycine in GSH antioxidant & #Inflammasome in #SmoothMuscleCell #SignalTransductTargetTher 2025 www.nature.com/articles/s41...

submitted 28 days ago • 0 comments

#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest

submitted 31 days ago • 0 comments

#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest

submitted 31 days ago • 0 comments

Vascular Tone of pressurized🐭distal MCA (sham & #IschemicStroke)⏫by BKCa inhibitor Brain Arterial #EndothelialCell BKca & TRPV4 (immunofluorescence)⏫by acute (0.5~2 h) #Hypoxia or #Stroke across🐁🐀🐖🚶‍♂️ @chrstaehr.bsky.social #ActaPhysiol 2025 onlinelibrary.wiley.com/doi/10.1111/...

submitted 45 days ago • 0 comments

Futile reperfusion of ischemic tissue after #stroke increases the risk of death and disabilities. Spatial transcriptomics provides new insights into the vascular alterations that drive this process. #BBB #cerebrovascular #neurosky #emedsky #medsky 🧪

submitted 49 days ago • 0 comments

Changes in endothelial cell large conductance calcium-activated potassium channels (BKCa) after #hypoxia may explain the altered myogenic tone which impacts blood flow following ischemic #stroke. #ionchannels #vascularbiology #physiology #cerebrovascular #endothelium #neurosky #emedsky #medsky

submitted 49 days ago • 0 comments

#SpatialTranscriptomics #Proteomics acute stage of #IschemicStroke (🐭tMCAO 24h) Molecular drivers of mural cell hyperconstriction & BBB disintegration in post-stroke futile reperfusion? A dual non-neuronal role of Calcineurin? @chrstaehr.bsky.social #Stroke 2025 www.ahajournals.org/doi/10.1161/...

submitted 50 days ago • 0 comments

🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.

submitted 52 days ago • 1 comment

Hello All Scientists! We are the Microcirculatory Society and we are excited to join the community here at BlueSky! Follow us for fun updates happening in the microvascular community and the amazing science being done by our scientists! #microcirculation #science

submitted 93 days ago • 1 comment

Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...

submitted 85 days ago • 1 comment

New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...

submitted 85 days ago • 0 comments

#Pericyte #PulmonaryHypertension 1/2 A subpopulation of Higd1b+ lung capillary pericytes 👉Migrate to distal arteriole 👉Upregulate Vimentin 👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping) in🐭Hypoxic PH #SciArt Ke Yuan lab @embojournal.org 2025 www.embopress.org/doi/full/10....

submitted 109 days ago • 1 comment

This is a groundbreaking study for pericyte fans. We discovered the unique pericyte marker Higd1b which only labels pericytes without any off-target effect from other mural cells.

submitted 109 days ago • 0 comments

New paper led by @silvia-anderle.bsky.social Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system, when neurons are active and mice do less exercise. I'll tell you all about it! 🧪 #neuroscience #alzheimers rdcu.be/d74uh

submitted 106 days ago • 3 comments

🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶 For more details see here research.chusj.org/RECHERCHE/fi...

submitted 112 days ago • 0 comments

Amazing organotypic effects of PDGFRβ+ #Pericyte Paracrine #Orangogenesis Pericytic BDNF/HGF KO🐭P1➡️ ⬇️Lung #Angiogenesis #Alveologenesis P21 No🧠effect Pericytic Nodal KO➡️ ⬇️Brain #Angiogenesis Disrupted #BBB Astrogliosis No🫁effect @ralfhadams.bsky.social 2025 www.researchsquare.com/article/rs-5...

submitted 108 days ago • 0 comments

Alert for Cardiovascular Grant writers, a must-archived 620-page paper😆 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Table 29 At-a-Glance Summary✌️ #Circulation 2025 @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

submitted 108 days ago • 2 comments

SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging ATF3 physically sequestrates MDM2 (E3 ligase for p21) ATF3 deficiency➡️ ⏬p21 protein stability ⏫ds DNA breaks ⏫Micronuclei ⏫cGAS-STING in SMCs #AortaEd Clin Transl Med 2024 onlinelibrary.wiley.com/doi/10.1002/...

submitted 107 days ago • 0 comments

Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in🐭Natural #Aging (18-mo) or D-galactose (for 8 wk) Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands. #AgingCell 2025 onlinelibrary.wiley.com/doi/full/10....

submitted 109 days ago • 0 comments

In the PARAMEDIC-3 trial involving adults with out-of-hospital cardiac arrest, an intraosseous-first strategy for vascular access did not result in a higher incidence of 30-day survival than an intravenous-first strategy. Full trial results: nej.md/48uYv4A #MedSky #CardioSky

submitted 109 days ago • 0 comments

For #FluorescenceFriday, microtubules (magenta) are shown with tau in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy

submitted 112 days ago • 1 comment

"It's much more fun when your hypothesis is wrong - I have learned much more from being wrong than from being right. Don't sweep contrary findings under your intellectual rug." - 10 lessons learned by Barry Levin 👇 pmc.ncbi.nlm.nih.gov/articles/PMC...

submitted 111 days ago • 0 comments

Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" A 🧵 1 journals.sagepub.com/doi/10.1177/...

submitted 113 days ago • 2 comments

Get your cerebral blood flow and metabolism abstracts in for Brain and BrainPET 2025 in Seoul! Deadline Feb 1st!! I’m so excited! www.brain2025.org

submitted 113 days ago • 0 comments

💉 Should calcium be used to treat #hyperkalemia? Our new systematic review in #Resuscitation (🔓 www.sciencedirect.com/science/arti...) found no evidence supporting calcium for hyperkalemia management. @ercresus.bsky.social #ILCOR

submitted 114 days ago • 1 comment

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

submitted 115 days ago • 0 comments

Bladder tissue regeneration using acellular synthetic PRS scaffold + instillation of conditioned medium from #MesenchymalStemCell & CD34+ HSPC vs blank media ⏫Smooth muscularization ⏫Size of regenerated blood vessel ⏫Innervation ⏫Urodynamics #AdvTher 2024 onlinelibrary.wiley.com/doi/10.1002/...

submitted 115 days ago • 0 comments

#SpatialTranscriptomics #Cartana in situ sequencing +snRNAseq 🐭Kidney development e15.5/18.5 P3 #SciArt A Critical Milestone KSTAT/Kidney Spatial Transcriptome Analysis Tool➡️ Single-cell mapping of regulon & enriched pathway biorRxiv 2024 @ondinecleaver.bsky.social www.biorxiv.org/content/10.1...

submitted 116 days ago • 0 comments

🧠 Our new study in Cephalalgia (journals.sagepub.com/doi/10.1177/...) explores genetic variants in FHM1-3 genes using @ukbiobank.bsky.social data. A genotype-first approach revealed that these 🧬variants ⬆️ #migraine risk—and surprisingly, a link to ⬇️ #epilepsy was discovered. Here’s what we found🧵

submitted 115 days ago • 1 comment

Beautiful #Immunity cover 🤩 Congratulations to Alessandro Matera (now an amazing postdoc in our lab 🙏) for his PhD thesis 🧪 tour de force! 🥳 @ale-matera.bsky.social, Anne-Claire Compagnion, Rosa Paolicelli & all authors for fascinating insights into #microglia biology www.cell.com/immunity/ful...

submitted 122 days ago • 1 comment

Very cool work!

submitted 127 days ago • 0 comments

Interesting how genetics keeps offering insights on lipids' effects on atherosclerosis🧬 ApoB-raising variants increase vascular risk by varying levels of magnitude per unit change in ApoB-particle number 👉TLR-particles 4x more than LDL 👉Lp(a)-particles 6x more than LDL 🧵1/5

submitted 127 days ago • 1 comment

Histopathology of👤Aortic wall remodeling Acute type A #AorticDissection N=5 <24 h postAD N=3 1~14 d N=4 0.5~3 mo #FalseLumen Granulation 0➡️761➡️423 µm Adventitial Fibrotic Collar Thickening 175➡️415➡️1078 µm Neovascularization #AortaEd Aorta (Stamford) 2024 www.thieme-connect.de/products/ejo...

submitted 132 days ago • 0 comments

🚨 Breaking #Physiology news: Spinal arteries dilate in response to #noradrenaline! Our new study (www.thespinejournalonline.com/article/S152... ) shows increased spinal cord blood flow in-vivo via β-adrenergic receptor–mediated vasodilation, as spinal arteries lack α1-adrenergic receptors.

submitted 135 days ago • 0 comments

New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...

submitted 132 days ago • 0 comments

www.pnas.org/doi/10.1073/...

submitted 132 days ago • 0 comments

Reminder to all cerebrovascular physiologists! Call for Papers in J Appl Physiol! Cerebrovascular Control in Health and Disease: From Modeling to Translational Research Send us your work ! journals.physiology.org/jappl/cerebr...

submitted 147 days ago • 0 comments