For my first-ever bluesky post, I'm really excited to share our new preprint "Geometric influences on the regional organization of the mammalian brain" with @alexfornito.bsky.social and a superstar 17-person team! (1/n) www.biorxiv.org/content/10.1... - ThreadSky

jchrispang.bsky.social • 23 days ago

For my first-ever bluesky post, I'm really excited to share our new preprint "Geometric influences on the regional organization of the mammalian brain" with @alexfornito.bsky.social and a superstar 17-person team! (1/n)

https://www.biorxiv.org/content/10.1101/2025.01.30.635820v1

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jchrispang.bsky.social•23 days ago

Following our recent work showing how geometry constrains function (https://nature.com/articles/s41586-023-06098-1), we ask whether geometry can also inform the regionalization of the brain.

This is an important question as parcellations/atlases are fundamental to many aspects of neuroscience. (2/n)

jchrispang.bsky.social•23 days ago

We know that patterning molecules (morphogens) are crucial for areal specification early in development. Interestingly, their expressions align with the rostrocaudal, mediolateral, and dorsoventral axes, corres. to low-order geometric modes. Image from O'Leary et al. (2017) (3/n)

jchrispang.bsky.social•23 days ago

Inspired by this equivalence, we use the geometric eigenmodes (which can be derived directly from T1w MRI) to develop a simple, hierarchical approach for generating a multiscale parcellation of any brain structure. We term as geometric parcellations. (4/n)

jchrispang.bsky.social•23 days ago

Focusing first on the human neocortex, we find that the geometric parcs produce regions that are more functionally homogeneous (FC based on 3 independent resting-state fMRI datasets) than those in nearly all 17 cortical parcs commonly used in the field. (5/n)

jchrispang.bsky.social•23 days ago

We also find that the homogeneity of the geometric parcs remains superior across 242 non-FC cortical phenotypes, covering diverse properties of morphometry, microstructure, cytoarchitecture, metabolism, gene expression, chemoarchitecture, and fMRI task activations! (6/n)

jchrispang.bsky.social•23 days ago

The great thing about our approach is that it only requires T1w MRI, so it is highly generalizable!

First, it is generalizable to mammals (macaque, marmoset, mousse neocortices), with superior homogeneity against 15 existing parcs across 114 FC and non-FC phenotypes. (7/n)

cedricboeckx.bsky.social•23 days ago

Terrific 👏👏

jchrispang.bsky.social•23 days ago

Thanks!

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