Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41... - ThreadSky

About ThreadSky

hjerling-leffler.bsky.social • 51 days ago

Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: https://nature.com/articles/s41467-024-55611-1

Comments

hjerling-leffler.bsky.social•51 days ago

🧠 1/4: Identifying the brain regions & cell types involved in psychiatric disorders is crucial to direct further studies. We integrated GWAS with a human single-cell transcriptomic atlas to prioritize cells/regions for #schizophrenia, #bipolardisorder, #depression, and more.

hjerling-leffler.bsky.social•51 days ago

🔬 2/4: Looking at brain regions, we saw a strong genetic risk for #schizophrenia enriched in the hippocampus and amygdala. This suggests that these regions are important to the etiology of the disorder. #BrainMapping #PsychiatricResearch #Genetics #BrainResearch #neurogenomics

hjerling-leffler.bsky.social•51 days ago

🧠 3/4: Analyzing existing fMRI data, we confirmed that the functional connections between the amygdala, hippocampus, and prefrontal cortex differentiate schizophrenia cases from controls. #Neuroimaging

hjerling-leffler.bsky.social•51 days ago

4/4 Our results show how convergent findings from the combination of genetics/transcriptomics & brain imaging reveal common targets for further studies and perhaps treatment.

hjerling-leffler.bsky.social•51 days ago

Lastly, I would like to thank @pgcgenetics.bsky.social and several other organizations for providing important data; as well as @vetenskapsradet.bsky.social , ERC and Swedish Brain Foundation (Hjärnfonden) for supporting our work

meletis.bsky.social•51 days ago

great study Jens!

giladsilberberg.bsky.social•51 days ago

Grattis Jens & co!

Posting Rules

Be respectful to others
No spam or self-promotion
Stay on topic
Follow Bluesky's terms of service

Comments

Posting Rules

Reply