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hjerling-leffler.bsky.social
Molecular Psychiatry, Neuroscience, Genetics, Professor at Karolinska Insitutet
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Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Detta är ett allvarligt underbetyg för 🇸🇪. Det är många aspekter som spelar in här: den stramare migrationspolitiken, informella värderingar som gör det svårt att komma in i det svenska universitetsväsendet utifrån & en slutenhet som tex illustreras av att Etikprövning bara kan göras på svenska.+

Check out this cool work from my superstar student Elie developing a new dimensionality reduction algorithm that compares two conditions! It works on many types of data

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/

We are looking for a PhD student! If you are interested in Drosophilids, systematics, bioinformatics, fiddling with museum specimens of old/weird flies, and chemosensation, then maybe this is for you! Please rebutterfly(?)! Apply below. lu.varbi.com/en/what:job/...

👇🏻Looking for a postdoc position? Want to do some truly innovative research on schizophrenia and the adolescent 🧠? How about a great boss? Jens has it all! Check it out.

Alert! Postdoc positions available - at least two. Interested in coming to Karolinska and work on adolescent development/schizophrenia? Have a background in neuroscience, functional genomics, computational analysis or spatial transcriptomics? Large data sets available for analysis. Get in touch!

Are you a researcher active outside of Europe who might consider coming to Sweden? Check out this @vetenskapsradet.bsky.social grant for recruitment of international visiting researchers! www.vr.se/english/appl...

PhD Position Available! 🧑‍🎓🧠🧬 We’re looking for a motivated PhD student to join our team and explore the fascinating world of human brain development and evolution. su.varbi.com/what:job/job...

Hot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...

Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...

One of Norway's largest fuel companies just announced that they will no longer refuel US Navy vessels after Trump’s treatment of Zelenskyy. “It made us sick... We encourage all Norwegians and Europeans to follow our example.”

Anybody know who the artist is? Please tag him/her in the comments, if you do. I found it in another post, without attribution. Would live to give credit. #USDemocracy #Voices4Victory #Opposition #SlavaUkraini

'Did you even say thank you?'

I want to thank all the people moving through my lab and all my collaborators for making this possible! Time do get dr*nk!

We have a new Professor in the house @ki.se ! Congrats Professor Jens Hjerling Leffler @hjerling-leffler.bsky.social!

A great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social To register 👇 news.ki.se/calendar/blu...

⚠️Useful!⚠️ Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures by Themistoklis Tsarouchas, @erinmgibson.bsky.social @lidazoupi.bsky.social @annawilliamslab.bsky.social #neurosky www.sciencedirect.com/science/arti...

Check out our latest paper, led by our good friends from @ki.se Thuy-Dung and Lu Yi, about the #genetic basis of psychotic major depressive disorder #MDD, a rare subtype of #MDD characterised by psychotic symptoms that occur exclusively during mood episodes! www.sciencedirect.com/science/arti...

Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely! can-acn.org/scientist-se...

Postdoc recruitment for an ERC-funded project! Are you eager to resolve embryonic cell fates with next generation single cell linege tracing? We use in utero barcoding & omics to map development, providing a basis for high throughput perturbations.. Pls re-post! Apply: ki.varbi.com/en/what:job/...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...

first thing to share here! excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning www.biorxiv.org/content/10.1...

Hey, so it turns out that paper on black plastic was a bit blown out of proportion by a simple math error. nationalpost.com/news/canada/...

Happy and tired after the lab’s yearly Christmas party! What a great year - one of my favorites as a PI - next will be even better 🎉