I should start by saying no physical issues. I destroyed both wrists in high school drum line so there's no sensation left to have. But I feel like no wireless mouse has performed well (Windows surely shares some blame), my wired mice don't feel good to use, and no great button layouts so far.
I feel strongly about this, but I recognize the changing times, so I usually settle for a wireless that can work while charging on a USB-C cable. Unfortunately that's another avenue for problems to pop up.
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