alangerber.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

It's out! Beautiful work led by Loreto Oyarte Gálvez & @cbisot.bsky.social! Do you want to learn more about how Mycorrhizal fungi extraordinary networks form and function? Read the open-access publication! Link below 👇

submitted 76 days ago • 0 comments

I am giving a lecture at the EMBO practical course: "FISHing for RNAs: classical to single molecule approaches" Check out this hands-on EMBO course!

submitted 143 days ago • 0 comments

Excited to share @domenicnarducci.bsky.social 's paper now out in Mol Cell published back-to-back with the paper from @dewitlab.bsky.social‬ - despite lots of prior work, we find that ZNF143 has no looping function www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

submitted 144 days ago • 1 comment

MDPI & Frontiers journals blacklisted in Finland, I wonder if this will indeed spread further? Never considered any of these journals for publication, but MDPI surely send funny emails... Maybe I will introduce myself like this 👇 from now on 😂.

submitted 144 days ago • 2 comments

"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles" www.biorxiv.org/content/10.1...

submitted 152 days ago • 5 comments

Not easy to describe the emotions of seeing our work published in @cellpress.bsky.social ! We explored how novel isoforms emerge during evolution through the exonization of Transposable Elements. Exonized TEs modify the functions and structures of host proteins. www.cell.com/cell/fulltex...

submitted 152 days ago • 6 comments

📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism @unil.bsky.social 🔗(PDF): www.jourdainlab.org/wp-content/u...

submitted 148 days ago • 1 comment

Excited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC ! Cool collaboration with the Müller and Eustermann Labs @embl.org ! academic.oup.com/nar/advance-...

submitted 153 days ago • 1 comment

🧪 Your eyes may deceive you. A study of 3,387 life-science papers from 2023 found nearly 1/3 of bar charts distorted data, often by not starting the y-axis at zero or misusing log scales.

submitted 155 days ago • 5 comments

🎉Excited to share our new preprint on Biorxiv 🥳 We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress! So what did we find? 🧵 www.biorxiv.org/content/10.1...

submitted 164 days ago • 4 comments

Metabolism and mRNA translation: a nexus of cancer plasticity www.cell.com/trends/cell-...

submitted 165 days ago • 0 comments

Paired CRISPR screens to map gene regulation in cis and trans https://www.biorxiv.org/content/10.1101/2024.11.27.625752v1

submitted 166 days ago • 0 comments

Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes https://www.biorxiv.org/content/10.1101/2024.11.26.625372v1

submitted 167 days ago • 1 comment

Very cool - snoRNA73 acts as a bridge between mRNAs and 7SL (i.e. the SRP ncRNA) to facilitate the synthesis of the encoded secreted protein.

submitted 168 days ago • 0 comments

A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs https://www.biorxiv.org/content/10.1101/2024.11.25.625186v1

submitted 168 days ago • 0 comments

Did you know that at our conference, we record our Keynote Lectures and make them freely available? You can find them all in our Youtube page! To get started, check out the 2023 IUBMB Jubilee Lecture, given by Prof. Rachel Green.

submitted 169 days ago • 0 comments

Post a non-religious photo you think of as holy. Not necessarily holy, just cool contrast between "then and now" in ribosome assembly landscape understanding. Nierhaus map from the 80s / AV Broeck & Sebastian Clinge in Science 2023.

submitted 169 days ago • 0 comments

This 👇 is happening. Change is coming!

submitted 170 days ago • 0 comments

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 by Ueli Laemmli! The paper which introduced SDS-page to the world!!! 💯

submitted 170 days ago • 1 comment

💯 February 14th 1969, RNA polymerases' day. The pioneering experiment that laid the foundation for the eukaryotic transcription field by Robert Roeder.

submitted 170 days ago • 1 comment

Post a non-religious photo you think of as holy

submitted 170 days ago • 1 comment

Post a non-religious photo you think of as holy.

submitted 171 days ago • 3 comments

Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function https://www.biorxiv.org/content/10.1101/2024.11.21.624739v1

submitted 171 days ago • 0 comments

IDH-mutant gliomas evolve from slow-cycling OPC-like cells to proliferative NPC-like cells through chromatin reprogramming and genetic alterations. This transition reveals key mechanisms of tumor progression. www.nature.com/articles/s43...

submitted 172 days ago • 0 comments

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

submitted 173 days ago • 12 comments

New on BioRxiv: We report a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body. Paper here: www.biorxiv.org/content/10.1... 1/

submitted 174 days ago • 2 comments

This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...

submitted 173 days ago • 1 comment

In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! www.biorxiv.org/content/10.1...

submitted 173 days ago • 1 comment

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O

submitted 173 days ago • 0 comments

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

submitted 174 days ago • 1 comment

New preprint on our method aa-tRNA-seq: chemically capturing aminoacylated tRNA molecules & pulling them through nanopores. It’s been a blast working with my collaborator Aleks Radakovic to take this from idea to promising pilot data to some looking exciting biology to chase down in future work.

submitted 175 days ago • 6 comments

Hello Bluesky community! What a better way to introduce myself and my research team than post our lab’s first paper freshly off press 🥳🍾 We reveal how tubulins regulate the stability of their mRNA via reversible sequestration of TTC5. Bravo A. Batiuk and all coauthors 👏🏻🥂 doi.org/10.1038/s414...

submitted 176 days ago • 1 comment

Our paper on a centromere-enriched retroelement is out! link.springer.com/article/10.1... Congratulations to all the authors! Comments and reposts welcome and appreciated 🧬🔬

submitted 176 days ago • 4 comments

Structural basis of tRNA-like small RNA generated from MALAT1 and NEAT1 www.nature.com/articles/s41... www.nature.com/articles/s41...

submitted 176 days ago • 0 comments

Don't miss our (updated) work on the developmental regulation of plant nuclear tRNA genes on Bluesky! #RNAsky #TransferRNA #Epigenetic #Chromatin #Tandemrepeat #Cluster #PlantTissue #TissularIdentity #Root #ProteinBiogenesis #Proteostasis #Glycoprotein www.biorxiv.org/content/10.1...

submitted 177 days ago • 2 comments

Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...

submitted 178 days ago • 1 comment

Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm https://www.biorxiv.org/content/10.1101/2024.11.14.623620v1

submitted 178 days ago • 1 comment

Happy to share our new paper with Goran Kokic and the Svejstrup lab in Cell! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by Diana, Marta and Paula! www.cell.com/cell/fulltex...

submitted 178 days ago • 5 comments