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Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

submitted 3 hours ago • 0 comments

Do you know (or are you) a senior scientist in the USA who might like to move to Canada in the near future? The 2026 call for CERCs (Canada Excellence Research Chairs) was posted last month: 🧪 ⚛️ 🔭 🇨🇦

submitted 2 days ago • 11 comments

Three UHN scientists have received funding to advance research on two rare diseases—one affecting the muscles and another impacting the liver. This can lead to new treatments. #RareDiseaseDay 🔗https://conscience.ca/news/dmos-program-funds-three-projects-working-towards-treatments-for-rare-diseases/

submitted 18 hours ago • 1 comment

I cannot think of anything that embodied America’s (former) values than the thousands of passionate Americans (formerly) affiliated with USAID programs who were out there trying to make life better for those not lucky enough to be the recipient of a $300m gift from Daddy.

submitted 1 day ago • 0 comments

For the second year in a row, UHN is ranked third among the world's best hospitals by @newsweek.com! 🏆 This recognition reflects of our unwavering commitment to excellence in care, research, and innovation to shape the future of health care and create #AHealthierWorld for all!

submitted 1 day ago • 1 comment

The analogy of what’s going on in the US to the Cultural Revolution is pretty apt.

submitted 2 days ago • 0 comments

Science advances our economic, physical, and social and cultural wellbeing, and is key to a sustainable future. However, we live in times of great change, and the values that have driven science for the benefit of humanity are under threat. Read our statement here: royalsociety.org/news/2025/02...

submitted 2 days ago • 26 comments

The brachyury structure, along with crystallographic fragment-based screening and enhanced compounds, may enable the development of chemical probes and future drugs. This approach could also be applied to other hard-to-drug transcription factors and proteins.

submitted 4 days ago • 0 comments

I learned it took only 22 years to build this and the grounds. Toronto transit, the gauntlet is thrown.

submitted 5 days ago • 1 comment

He shoots, he scores! Oh Canada!

submitted 7 days ago • 0 comments

🔬 The Chemical Probes Hackathon is underway in Vienna! Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration. Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes

submitted 7 days ago • 0 comments

Seeing more and more talks looking at proteins purified from cells (or in cells) by cryo-EM and discovering new protein interactions by “seeing” them in place. It’s just so, so cool.

submitted 8 days ago • 0 comments

Canada, step up and double down on support for science and innovation. Now’s the time says @richardgold.bsky.social

submitted 8 days ago • 1 comment

About NIH Program Officers. I have troves of emails from various PO’s over past years. Emails sent at nights, on weekends, filled with passion about science and new ideas. They’re one of the shining lights of the US funding system. Canada is so envious. Unbelievable to watch the US own goal.

submitted 11 days ago • 0 comments

Pro tip for travelling light on business. This trip, one carry on, one month. To minimize laundry trips, wear coffee coloured pants and have one sacrificial shirt only for breakfasts. Proved their worth today!

submitted 14 days ago • 0 comments

With both RFK Jr and Gabbard confirmed, two people who rose to prominence spreading conspiracy theories about public health and national intelligence will now run the U.S. government agencies in charge of those areas. For someone studying these conspiracy theories for a decade... this is nauseating.

submitted 14 days ago • 186 comments

✨Symposium session reveal✨ Featuring @albertantolin.bsky.social and @karmencj.bsky.social, this session highlights initiatives enabling communities to come together to solve some of the biggest challenges in drug discovery. Register here: conscience.ca/symposium2025

submitted 16 days ago • 0 comments

My son, who’s lives in BC and is a great skier, has taken up telemarking to challenge himself. But he ain’t a small guy, so evidently his buddies are calling him “Teletubby”!

submitted 18 days ago • 0 comments

Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic. globalnews.ca/news/9793403...

submitted 18 days ago • 527 comments

About to e-deposit the $200 bribe from the Ontario Conservative Party, sent to all Ontario tax payers (voters). This clinches it! Doug Ford’s got my vote in the provincial election next month!

submitted 19 days ago • 0 comments

More than 25 years after FXR agonist GW4604 was described by now @thesgc.bsky.social scientist Tim Willson, it is still being used in cutting edge papers. High quality #ChemicalProbes are expensive to discover, but they’re the gift that keeps on giving. www.nature.com/articles/s41...

submitted 22 days ago • 0 comments

Embedded in Derek’s post is a frightening yet plausible conclusion. That some politicians are reluctant to counter Trump’s actions out of fear for their (and their family’s) personal safeties.

submitted 22 days ago • 5 comments

Senator, physician and vaccine advocate Bill Cassidy votes to advance anti-vaccine Kennedy’s candidacy to lead public health in the US. A potential disaster for children in the US and beyond. Perhaps Cassidy took the Hypocritic oath instead of the Hippocratic oath. Shame on him.

submitted 22 days ago • 0 comments

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @uhntoronto.bsky.social, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. event.fourwaves.com/aircheckwork...

submitted 22 days ago • 0 comments

submitted 23 days ago • 1 comment

Let’s see how that Hippocratic oath fares. Bill Cassidy, a U.S. Senator who dedicated his medical career to saving lives through vaccination is evidently “struggling” on the decision whether to vote for an anti-vaxxer to be put in charge of American healthcare. www.nytimes.com/2025/02/04/u...

submitted 23 days ago • 0 comments

Feeling betrayed by tariff threats, Canadians do their part by avoiding buying American goods when possible. www.cbc.ca/news/canada/...

submitted 23 days ago • 0 comments

There is nothing "conservative" or "right-wing" about Patel, Gabbard or RFK Jr. They rather represent a new form of obscurantist radicalism: anti-evidence, anti-science, and opposed to the rule of law www.theatlantic.com/magazine/arc...

submitted 24 days ago • 66 comments

If you can, do something, speak up and act up. www.science.org/doi/10.1126/...

submitted 25 days ago • 4 comments

RONALD REAGAN (1988): We should be aware of the demagogues who are ready to declare a trade war against our friends, weakening our economy, our national security, and the entire free world—all while cynically waving the American flag.

submitted 25 days ago • 1977 comments

What we need now are some American heroes. Hero Senators who vote against dangerous conspiracy theorists. Hero Congresspeople who forcefully take back their constitutional right to hold the purse strings of the nation. Heroes who work to keep America great.

submitted 25 days ago • 0 comments

Thanks America. With friends like you, who needs enemies. Sincerely, Canada.

submitted 26 days ago • 0 comments

🧪 If I were Canadian PM I would immediately: 1. Create a new $15B science fund 2. Offer any credentialed US scientist funding for lab startup and replacement of NIH grants if they move to Canada 3. Immediate permanent residency 4. Citizenship after 2 years Overnight a science superpower

submitted 27 days ago • 1298 comments

Time for Canada, its provinces and its political parties to pull as one and align with other nations to stand up to the tariff bully, it appears. Yield now and it’s never going to stop (at least for two more years when a blue wave will sweep through the US Congress). Let’s go Team Canada!

submitted 27 days ago • 0 comments

On #WorldNTDDay, we want to say a huge THANK YOU to all our partners and donors for their support. Thank you for helping us bring the best science to the most neglected.🔬 🤝Our partners: dndi.org/partnerships... 🙏Our donors: dndi.org/about/donors/

submitted 28 days ago • 0 comments

>20 yrs ago, while at GW, now @thesgc.bsky.social UNC scientist Tim Willson and his team invented (and then shared) LXR agonist GW3965. And that GW3965 #chemicalprobe is still having an impact, including in a new study in which we played a small role. www.nature.com/articles/s41...

submitted 29 days ago • 0 comments

Fun listening to Karina Machado tell the story about how her team did so well in the #Cache compound prediction challenge. Scientists in the global south can compete with anyone on the planet if given a level playing field!

submitted 29 days ago • 0 comments

Yann LeCun, leader of A.I. at Meta. “China is beating the United States at A.I.” is misreading the situation The correct reading is: ‘Open source models are surpassing proprietary ones, and because their work is published and open source, everyone can profit from it.” www.nytimes.com/2025/01/29/t...

submitted 29 days ago • 0 comments

🔬 Calling all PhD students & postdocs in chemistry/biology! Join us at the Chemical Probes Hackathon 🧪: 🗓️ Feb 20, 2025 | 10:00–14:30 📍 Vienna, Austria 💡 Evaluate chemical probes w/ experts & improve global science 🌍. 🎓 Earn a Certificate of Attendance! Learn more & register 👇

submitted 31 days ago • 1 comment

Neglected tropical diseases are a global health emergency 🚨 Join us in developing urgently needed treatments for neglected patients, ensuring they are affordable, available & adapted to the communities who need them. We must #UniteActEliminate to #BeatNTDs. #WorldNTDDay

submitted 31 days ago • 0 comments

Scientific fraud makes headlines, but it’s thankfully rare and is (eventually) corrected. What’s far more concerning, in my opinion, are the thousands of papers that mislead because they use poorly characterized reagents, like antibodies, cell lines and chemical probes. www.nytimes.t/2025/01/24/o...

submitted 32 days ago • 0 comments

🎙️ New podcast episode alert! Professor Paul Workman joins Opher Gileadi on the #Target2035 podcast to dive into the science of chemical probes. 🧪 🔍 What makes a great probe? 🛑 Common lab mistakes. 🌐 Learn about the Chemical Probes Portal. 🎧 Listen now 👇

submitted 34 days ago • 1 comment

Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions. They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).

submitted 36 days ago • 11 comments

🇺🇸-->🇨🇦. Now is the time. We are a poor, but proud country. And very friendly. Sick Kids has plenty of resources, so look here 👇

submitted 35 days ago • 1 comment

Indeed, there are a number of open positions for early career investigators in Toronto. It's a great city in a great country to pursue impactful science.

submitted 35 days ago • 1 comment

Trump is threatening a national emergency. Canada should respond by using its rights under the Patent Act to effectively suspend US-controlled patents. www.theglobeandmail.com/business/com...

submitted 36 days ago • 2 comments

Ever wonder where Nobel Prize-winning AlphaFold got its training data? Read how pioneering crystallographer Helen Berman helped build the Protein Data Bank as a home for more than 200,000 protein structures that would come to shape AI and protein prediction ➡️

submitted 38 days ago • 2 comments

Roman/Nazi salutes, demonizing the press, threatening judges, pardoning violent criminals, expansionist threats against other countries. Déjà vu. Legitimately frightening.

submitted 37 days ago • 0 comments

Today let’s celebrate the life of Martin Luther King. "I have the audacity to believe that peoples everywhere can have three meals a day for their bodies, education and culture for their minds, and dignity, equality, and freedom for their spirits." Nobel Peace Prize speech, Oslo, Norway, 1964

submitted 38 days ago • 0 comments

Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV. @mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine cns.utexas.edu/news/announc...

submitted 41 days ago • 3 comments