Profile avatar
aliciapcv.bsky.social
EMBO postdoctoral fellow, San-Millán lab @cnb-csic.bsky.social | CRISPR, Plasmid Biology, Bacterial EcoEvo & AMR | Sci-Illustrator | PhD in Bikard Lab, @pasteur.fr 🇫🇷 | She/Her | From 🇪🇸 & 🇵🇹
33 posts 370 followers 503 following
Regular Contributor
Active Commenter
Posts 23 Comments 27

I just posted "Some Experiments Work, and Some Don't." It features this new paper from Paul Rainey's group, along with a *failed* experiment that Paul Sniegowski and I ran in the 1990s trying to test the same idea. telliamedrevisited.wordpress.com/2025/02/21/s...

submitted 2 days ago • 2 comments

C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new @cellpress.bsky.social #CellSystems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ authors.elsevier.com/sd/article/S...

submitted 17 days ago • 1 comment

Excited🚨to share our first work on the human gut phageome doi.org/10.1101/2025... Always inspiring to work with @epcrocha.bsky.social , Erick D, Camille d'H and everyone else within this super dynamic consortium @[email protected][email protected]! Many thanks for this great journey!🙌

submitted 14 days ago • 3 comments

Happy International Day of Women and Girls in Science 👩‍🔬🧬 #womeninscience #girlsinscience

submitted 13 days ago • 2 comments

Hoy en el Ciclo #VisiblesCNB ampliamos nuestra mirada hacia las ciencias sociales con la ponencia de Mercedes Álvarez, profesora de Comunicación en @uc3m.es sobre la representación de género y su evolución en la animación. @csic.es @csicdivulga.bsky.social #DíaMujeryNiñaCiencia #TodasHacemosCiencia

submitted 18 days ago • 0 comments

Happy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...

submitted 19 days ago • 3 comments

Exciting to see our paper now published 🙌 www.science.org/doi/10.1126/... In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

submitted 24 days ago • 2 comments

¡Acompáñanos el 6 de febrero a las 10:00h en el CNB! Con motivo del #11F #díamujeryniñaenciencia, tendremos una interesante conferencia sobre personajes de animación, con Mercedes Álvarez San Román, profesora de Comunicación de la @uc3m.es #TodasHacemosCiencia @csic.es @csicdivulga.bsky.social

submitted 25 days ago • 0 comments

Could not recommend this fellowship and program enough.

submitted 27 days ago • 1 comment

The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky

submitted 28 days ago • 1 comment

Here's our new preprint led by @aleciarokes.bsky.social and @vscooper.micropopbio.org We investigated how two isolates obtained before and after clinical antibiotic use adapt to tigecycline. Hope you like it!

submitted 31 days ago • 0 comments

New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time. www.biorxiv.org/content/10.1...

submitted 30 days ago • 5 comments

New preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!

submitted 30 days ago • 2 comments

🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

submitted 31 days ago • 4 comments

✨Rethinking life's origins: Could stable molecular networks, or 'evosystems,' have kickstarted evolution before traditional reproduction?✨ An hypothesis paper by @vdlorenzo.bsky.social, @brionesci.bsky.social & colleagues https://academic.oup.com/microlife/article/doi/10.1093/femsml/uqae025/7931236

submitted 42 days ago • 0 comments

⚠️ Job(s) alert! ⚠️ We are launching a new postdoctoral program in Systems Biology at IBFG. Join us! 👉 Several positions available with competitive work conditions for up to 4 years 📄 More info: jdiazc9.github.io/files/jobs/2...

submitted 38 days ago • 0 comments

Proud Pasteurienne over here :)

submitted 39 days ago • 0 comments

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

submitted 39 days ago • 1 comment

What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...

submitted 46 days ago • 3 comments

🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️

submitted 45 days ago • 2 comments

I'm new here, so I'll share our recent work here too 😁🧫 Using Tn-seq + live imaging in engineered airway organoids, we explored the fitness tradeoffs P. aeruginosa faces while growing and surviving antibiotic treatment on the mucosal surface. Check it out: www.nature.com/articles/s41... #MicroSky

submitted 105 days ago • 2 comments

Very happy to see this work published! We unveil a plasmid-chromosome crosstalk by showing that pOXA-48 encodes for a regulator that mediates the transcription of an enterobacterial chromosomal operon, resulting in a growth benefit for the plasmid-carrying bacteria! www.nature.com/articles/s41...

submitted 53 days ago • 2 comments

Now updated! www.biorxiv.org/content/10.1...

submitted 73 days ago • 0 comments