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amh10.bsky.social
Medical Microbiologist & Clinical Services Director @UKHSA BPHL. All posts my own. #QI #ClinGov
85 posts 884 followers 1,236 following
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Therapeutic drug monitoring of antibiotics for methicillin-resistant Staphylococcus aureus infections: an updated narrative review for clinicians - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

How to: assess patient suitability for unlicensed phage therapy in the United Kingdom - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Aztreonam and avibactam combination therapy for metallo-β-lactamase-producing gram-negative bacteria: a comprehensive review - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Diagnostic test accuracy of the Fungitell serum (1→3)-β-D-glucan assay for the diagnosis of Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Oral switch vs. continued intravenous antibiotic therapy in patients with bacteraemia and sepsis: a systematic review and meta-analysis - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Biomarkers in paediatric bacterial meningitis: a systematic review and meta-analysis of diagnostic test accuracy - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Performance of molecular tests for diagnosis of bloodstream infections in the clinical setting: a systematic literature review and meta-analysis - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Decoding community-acquired pneumonia: a systematic review and analysis of diagnostic criteria and definitions used in clinical trials - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

What is the most effective antibiotic monotherapy for severe Pseudomonas aeruginosa infection? A systematic review and meta-analysis of randomized controlled trials - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

Diagnostic accuracy of 16S rDNA PCR, Multiplex PCR and Metagenomic Next-Generation Sequencing in Periprosthetic Joint Infections: A Systematic Review and Meta-Analysis - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.com/article/S119...

PJIs & biofilm’s still keeping you up at night? Dr. Julie Ann Justo is joined by Dr’s Nicolas Cortes-Penfield, Jessica Seidelman, & Kerry LaPlante to discuss using abx to help treat these infections in the latest breakpoint episode # 110 “A Bone to Pick: Biofilm Busters for PJIs”. Listen today!

After what I have seen over the last few days, the time has come.......

The well-worded press release. @pasteur.fr has decided to leave X because of several serious abuses observed on the platform since its takeover. Suspending their day-to-day activities on the platform immediately and encouraging their subscribers to follow on other platforms, especially Bluesky.

www.thelancet.com/journals/lan...

Tetracyclines: new and old - www.cmi-comms.com/article/S295...

www.ahajournals.org/doi/10.1161/...

www.atsjournals.org/doi/full/10....

Macrolies plus SOC does not seem to affect CAP outcome: academic.oup.com/jid/advance-...

The negative predictive value of TTP>13 hours for endocarditis was 96% (95% CI 95-97). What about the transport time? academic.oup.com/cid/advance-...

Flucloxacillin: 7x higher risk of drug induced liver injury Vs clindamycin: www.clinicalmicrobiologyandinfection.com/article/S119...

journals.lww.com/pidj/fulltex...

academic.oup.com/jac/advance-...

www.tandfonline.com/doi/full/10....

➡️ Does your 🏥 use the Blood culture strategy of; ONE venipuncture (4 bottles x 1 puncture) or TWO venipunctures (2 bottles x 2 punctures) ➡️ If ONE, do you like it? #IDsky #Medsky

www.scientificamerican.com/article/how-...

www.scientificamerican.com/article/if-p...

link.springer.com/article/10.1...

Dual beta lactam administration? www.idstewardship.com/dual-beta-la...

Revisiting the Evidence Base That Informs the Use of Adjunctive Therapy for Enterococcus faecalis Endocarditis: A Systematic Review and Meta-Analysis academic.oup.com/cid/article-...

For #WAAW2024 I would like to highlight a free 20 lecture series our UCL AMR Digital Data Hub has created - available at digitalamr.org/lecture-series - Part A covers The AMR Challenge, and Part B Emerging digital health technologies for AMR - a great starter for digital health trends in AMR

academic.oup.com/jac/advance-... Just published the first case of penicillin-resistant group B Streptococcus isolated from a patient in the UK - though of note this was from 2016 and we have not seen any further penicillin resistance since - however a salient reminder that #AMR is ever a possibility

🔥BALANCE RCT🔥 74 hospitals in 7 countries 3,608 patients A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky www.nejm.org/doi/full/10....

Clear recommendation: Cranberry products can reduce the recurrent UTIs in women, children, and individuals susceptible to UTIs. Data for older people, those with bladder emptying problems, or pregnant women is insufficient #utisky #medsky #idsky

While the absence of pyuria can help rule out infection in most patient populations, the positive predictive value of pyuria for diagnosing infection is exceedingly low as it often indicates the presence of genitourinary inflammation due to many other possible noninfectious reasons #utisky #medsky

🆕️🔥Systematic review 4 retrospective studies N:752 The use of pip/tazo for open fractures does not differ from 1st G cephalosporins +/-aminoglycoside in regard to SSI,AKI,return to OR, 1-year mortality,non-union& development of resistant pathogens #idsky #medsky www.sciencedirect.com/science/arti...

Endocarditis therapy has long been based on opinions of eminent experts rather than high-quality evidence 🔥PUBLISHED🔥 Our editorial with Dr.Spellberg✨️ @dremilymcd.bsky.social @drtoddlee.bsky.social Endocarditis Therapy: The Move From Expert Opinion to Evidence www.sciencedirect.com/science/arti...

🆕️⚡️⚡️Prospective cohort study In patients with septic shock, culture-negativity was associated with increased mortality, despite the paradoxically higher appropriateness of empirical antibiotics than culture-positive patients #idsky #medsky ccforum.biomedcentral.com/articles/10....

Trichophyton mentagrophytes genotype VII! www.imdb.com/title/tt3184...

Our @shorten2trial.bsky.social aims to confirm that 7-day treatments are superior to 14-day courses for uncomplicated P. aeruginosa BSI. Check out our full protocol 👉🏻 journals.plos.org/plosone/arti... #AMSsky #IDSky

Who Are the HACEK Organisms? asm.org/Articles/201...

No evidence of difference in mortality with amoxicillin versus co-amoxiclav for hospital treatment of community-acquired pneumonia www.journalofinfection.com/article/S016...

New PhD project with Zubair Ahmed at Uni Birmingham on gut-brain axis. I am second supervisor www.findaphd.com/phds/project...

Nov 18-24 is #WAAW2024 or the World Antimicrobial Awareness Week. This WAAW, let’s be aware of #AMR, its causes, and how to combat it. This infographic is brought to you by the Pediatric Infectious Disease Society of the Philippines. #PIDSP #abxstewardship #AMS #AMSisthebest

Next week is #AntibioticAwarenessWeek so we’ve gone blue (blue-er?) AND we are marking the event with a #journalclub highlighting some of the excellent #AMR papers published by our customers 🤩💊🦠🧬 #WAAW2024 #GoBlueforAMR #WAAW #AntibioticResistance #MicrobialGenomics #WGS #MicroSky

📣🛡️💊 Quick 5 things to celebrate the week! 👉 www.idstewardship.com/5-ways-celeb... #USAAW #USAAW2024 #WAAW #WAAW2024