antoinegc.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🧠🍀Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study www.bmj.com/content/377/...

submitted 1 day ago • 0 comments

Lovely collaboration with Renaud La Joie - our review is finally out! Summarizing the role of tau and TDP-43 in medial temporal atrophy in Alzheimer's disease and exploring different hypotheses regarding their potential timing and synergism. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 3 days ago • 1 comment

🖥️🧠💪🏾 An online multidomain lifestyle intervention to prevent cognitive decline in at-risk older adults: a randomized controlled trial 👉🏼'At 3 years, the mean change in a global cognitive composite, the primary outcome, was met.' www.nature.com/articles/s41...

submitted 12 days ago • 0 comments

🧠Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease braininformatics.springeropen.com/articles/10....

submitted 15 days ago • 0 comments

Longitudinal Cognitive Changes in Cerebral Small Vessel Disease The Effect of White Matter Hyperintensity Regression and Progression www.neurology.org/doi/10.1212/...

submitted 17 days ago • 0 comments

White matter hyperintensities and TDP-43 pathology in Alzheimer's disease 👉AD-TDP type-α showed greater total and regional WMH burden (particularly in subcortical frontotemporal and basal ganglia regions) than TDP-43 negatives and AD-TDP type-β. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 36 days ago • 0 comments

🚨New paper ! Thrilled to share this work on neuropsychological profile in older adults with end-stage kidney disease during kidney transplantation evaluation 🧠 @hcl-recherche.bsky.social @mickaelbob.bsky.social @teddynovais.bsky.social shorturl.at/nPYb4 1/🧵

submitted 38 days ago • 4 comments

This study highlighted that anticholinergic and sedative medications to avoid in older people are still frequently prescribed despite the development and regular updating of potentially inappropriate medication criteria agsjournals.onlinelibrary.wiley.com/doi/10.1111/...

submitted 42 days ago • 1 comment

🚨Paper alert Happy to share the work published in Alz&Dem (DADM), led by our biologist colleagues @hcl-recherche.bsky.social ✨a "commercial-only" CSF aSyn-SAA protocol exhibited excellent specificity in 'real-life cohort'(sp100%, se72%) alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 42 days ago • 0 comments

A meta-analysis of loneliness and risk of dementia using longitudinal data from >600,000 individuals www.nature.com/articles/s44...

submitted 45 days ago • 0 comments

Endothelial cells as key players in cerebral small vessel disease @natrevneurol.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

submitted 53 days ago • 0 comments

🚨Paper Alert🚨 Thrilled to share this paper published in the @agsjournal.bsky.social , on the prevalence of anticholinergic and sedative drugs used in older adults (aged 65+)💊🧠 👉data from the 🇫🇷French National Health Data System (#SNDS) 👉n=16,938,152 🚨prevalence=32.8% shorturl.at/0PsQF 🧵👇1/

submitted 55 days ago • 4 comments

Deep learning reveals pathology-confirmed neuroimaging signatures in Alzheimer’s, vascular and Lewy body dementias academic.oup.com/brain/advanc...

submitted 56 days ago • 0 comments

Primary Progressive Aphasia Lacking Core Features of Nonfluent and Semantic Variants Clinical, Neuroimaging, and Neuropathologic Features www.neurology.org/doi/10.1212/...

submitted 56 days ago • 0 comments

Is a mood change an early 'tell" in Creutzfeldt-Jakob disease (sCJD)? Maybe. Are there changes in prescription medication use preceding clinical onset? Could 'increased vigilance for depression and mood changes in neurodegenerative diseases extend the diagnostic window?'

submitted 56 days ago • 0 comments

🤯Postoperative delirium: An independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery🤯 www.sciencedirect.com/science/arti...

submitted 56 days ago • 0 comments

New paper alert🎆 ”Why do some brains age faster?”🧠 📌Diabetes, SVD, inflammation, high glucose linked to “older” brains 📌Physical activity may offset obesity's impact, mantaining brains younger 📌 Sex differences. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 63 days ago • 0 comments

« Les coûts de l’inaction sont trop élevés », précise l’OCDE. Les projections d’un scénario du « vieillissement en bonne santé » montrent que cela permettrait de contenir l’augmentation de la part des dépenses de santé dans le PIB et de contenir les coûts des soins de long terme.

submitted 62 days ago • 1 comment

Thrilled to share our latest work on the importance of considering social identities in brain imaging research, now out in @natureneuro.bsky.social. rdcu.be/d4XWM

submitted 62 days ago • 3 comments

💡Placental growth factor (PlGF) is a promising biomarker (plasma🩸) for vascular contributions to cognitive impairment and dementia (associated with cSVD & WMH)🧠. This study explores the relationships between white matter free water, PlGF, WMH & cognition. @wilcocklab.bsky.social shorturl.at/0V86i

submitted 64 days ago • 0 comments

💡 Differences in baseline cognitive performance between participants with early-onset and late-onset AD 🧠 👉EOAD : ↘️visuospatial, executive functioning, and processing speed/attention skills relative to LOAD 👉LOAD : ↘️ language, episodic immediate and delayed memory shorturl.at/4rg4Y

submitted 64 days ago • 0 comments

Thromboembolic events and vascular dementia in patients with atrial fibrillation and low apparent stroke risk www.nature.com/articles/s41...

submitted 67 days ago • 0 comments

🔍 Our study highlights the frequent prescription of anticholinergic drugs in patients with chronic kidney disease (CKD) and their potential link to cognitive impairment. 📊 Graph: Therapeutic classes of anticholinergic drugs most commonly prescribed in the CKD-REIN cohort

submitted 79 days ago • 1 comment

Are AI large language models cognitively impaired ? 🎄BMJ

submitted 67 days ago • 0 comments

V interesting study in @bmj.com USA Taxi drivers & ambulance drivers are less likely to die of Alzheimer's disease than people of other professions Links made to Eleanor Maguire's famous discovery that the posterior hippocampus of London taxi drivers was larger than controls. My thoughts in🧵

submitted 72 days ago • 6 comments

In response to Eric Topol's post on the @bmj.com article, lots of people asking if playing video games might reduce Alzh.Dis mortality. No one knows, but we found more hours playing video games is linked to better navigation skill. So possibly... Article: www.sciencedirect.com/science/arti...

submitted 71 days ago • 0 comments

🧠🚕🧠🚕 "Taxi drivers and ambulance drivers, occupations involving frequent navigational and spatial processing, had the lowest proportions of deaths attributed to Alzheimer’s disease of all occupations." 🗺️🗾💪 @antoinecoutrot.bsky.social @hugospiers.bsky.social

submitted 71 days ago • 0 comments

🧠♥️ In patients with heart failure and preserved ejection fraction, even modest baseline impairment of cognitive function was associated with worse outcomes, including death www.ahajournals.org/doi/abs/10.1...

submitted 75 days ago • 0 comments

⚠️ New preprint ! "Separable cognitive & motor decline tracked across adult life-span for goal-directed navigation" Giovanni Pezzulo's lab modelled the trajectories in Sea Hero Quest to reveal dynamic patterns of goal-directed control and their decline with age: www.biorxiv.org/content/10.1...

submitted 77 days ago • 0 comments

Quelle meilleure occasion de lancer notre présence sur ce réseau, que la journée Recherche qui se tient aujourd'hui ! De nombreux participants et des intervenants d'exception participent à cette journée, et un programme riche nous attend. #Recherche

submitted 78 days ago • 0 comments

Social determinants of cognitive aging trajectories across 39 countries https://www.medrxiv.org/content/10.1101/2024.12.05.24318553v1

submitted 81 days ago • 0 comments

Exciting new results from our Sea Hero Quest project: Research led from @antoinecoutrot.bsky.social's lab in Lyon exploring trajectories of cognitive ageing. Great thread from Antoine below:

submitted 80 days ago • 1 comment