atkeinath.bsky.social
Hip, hip, hippocampus! Neuroscientist studying our personal space. Assistant professor at UIC. Head of the Keinath Lab since ‘23. 🏳️⚧️ wedobrainstuff.com
19 posts
147 followers
186 following
Regular Contributor
Conversation Starter
comment in response to
post
It’s real rn!
comment in response to
post
Can’t wait Andy! Definitely stoked to catch up!
comment in response to
post
Thanks Q! And thanks for your feedback on the draft! :)
comment in response to
post
Looks like a Friday to me!
comment in response to
post
Great Q (@dahery.bsky.social brought this up in lab meeting)! We can't rule this out during the free navigation experiment, but the finding that changing navigation (while keeping geo constant) changes CA1 in a directional and transient way is harder to account for from a purely geo theory.
comment in response to
post
Yes! Literally the first name I searched for when I got this account haha. She was a staple of my neuro twitter!
comment in response to
post
Thanks! And thanks for establishing the paradigm! Happy that the reality turned out more interesting than we had anticipated. :)
comment in response to
post
Definitely one reason I think. Also, the scale matters a lot in our data: similarity of movement within compartment on a few centimeter- and 1 sec scale matched CA1 but not transitions between compartments. Also, behavior during early experience, not after familiarization, was strongest.
comment in response to
post
Yes indeed! I think there’s a few reasons why, happy to chat about it. :)
comment in response to
post
Thanks Adrien! It's been exciting to see it develop from (what we thought would be) a simple story about orientation into a much more interesting tale of individual differences and behavioral determinants. Feedback is definitely welcome!
comment in response to
post
These results demonstrate that idiosyncratic navigation determines CA1 representational structure (behavior matters!), consistent with predictive cognitive mapping. Big thanks to my first graduate student @sergiopecirno.bsky.social who led this, and Mice 4 and 5 the real MVPs! Feedback welcome!
comment in response to
post
(3) Finally, we limit the mouse’s navigational options to change their navigational patterns. This induces a change to CA1 remapping structure to match the new pattern of navigation. Afterwards both behavior and CA1 revert to their OG structures. (Yes, that is 43 sessions of data for each mouse)
comment in response to
post
(2) Within mouse, compartments that have similar navigational patterns (i.e. similar successor matrices) on a second-long timescale during early experience are represented more similarly in CA1. Between-compartment transitions did not match CA1. (Spatiotemporal scale looks suspiciously like BTSP?)
comment in response to
post
Three primary findings. (1) Different mice show different patterns of remapping across identical unrewarded compartments. Doesn’t matter if we use rate map-based measures or location-agnostic measures. Same environment, different maps for different mice. Already a strike against geometric theories.
comment in response to
post
I literally *JUST* talked about this paper in my last class. Such cool work!