baylinklab.bsky.social
🦠Enthusiastic microthanatologists (i.e. the study of how to kill microbes) & lovers of redox biology and bacterial chemotaxis🧫
Washington State University - Esch LEAD Professor - Inclusion of Rural Individuals in Science (IRIS)
www.baylink-lab.com
116 posts
387 followers
559 following
Regular Contributor
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A fair question. Yes, but would keep private for @bsky.app since I would be calling out specific accounts as spam.
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And if you are interested in the "behind the paper" story...
urldefense.com/v3/__https:/...
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Looking forward to these days ahead. Right now our only experiments are with the *hehem* microbiome.
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Can someone explain why they would do this?
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1. Be your own harshest reviewer
2. For your writing to succeed you must connect effectively with your readers (and not confuse them)
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We are aware of this. This is one of the reasons co-treatment with a PPI is standard.
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And they do not.
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A simple but useful test!
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The youtube version of the video can be found here, which has the advantage of subtitles:
youtu.be/4uNjRb-NyM4
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Thank you for considering supporting our research on these new avenues for the prevention of stomach cancer and stomach ulcers. These diseases affect many people and it will be an interesting experiment to see if crowd-sourced funding is an option for continuing this work.
gofund.me/056747fe
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The crowd-sourced funding campaign and video were the result of a student-lead effort supported by the Esch LEAD program at @pullman.wsu.edu.
The program seeks to integrate students from non-science backgrounds with research labs.
vetmed.wsu.edu/education/un...
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We are seeking donations through a GoFundMe account to continue our research into these potential new treatments. Early work suggests very promising results - they appear to effectively kill even multi-drug-resistant types of H. pylori. Also appear to have low or no toxicity.
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Craig, see some ideas here. I did the same deep dive a few years ago. Happy to chat about what my coauthor and I found.
pubmed.ncbi.nlm.nih.gov/34274196/
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IMO, it’s important to explain the value of NIH-funded research in ways that might persuade people who support the cuts—not just using language and examples that resonate with academics. There are a lot of folks out there backing the cuts.
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Myth: hydrogen peroxide easily kills bacteria (in the context of infection)
Reality: Lots of bacteria tolerate mM H2O2, more than produced by the body. H2O2 isn’t very reactive. Lethality is from things like ROOH, HOCl, OH-. , ONOO-.
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Certainly! We are the omeome.
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Here are before and after fecal treatment 'time lapse' images. Each squiggle is the swimming path of 1 bacterium over 5 seconds.
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Right?!
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Video shows swimming E. coli over a 5 minute duration. The glass capillary that lowers into solution is injecting a constant source of liquid human fecal matter, modeling what the bacteria experience inside the intestines. They are attracted to the nutrients in the poo.
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Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky
wgntv.com/evanston/nor...
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Dont be too hard on yourself
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X-ray crystallography ftw
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Feel free to steal it
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On this, I will have to take your word.
But our compounds are geared toward a different problem than the one you suggest.
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Another way to view this type of data is with 'max projections' that show a time lapse of the bacterial movement. Here is before and after exposure to fecal treatment. The green lines are all swimming E. coli shown over a 5 s interval.
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Video plays at 10x speed, showing E. coli strain MG1655 with a GFP reporter. If you look carefully, you can see a glass capillary lower into the solution, which injects a constants source of liquid human poo. Data is part of our revisions for: doi.org/10.7554/eLif...
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Very cool. There used to be products to build entire proteins to scale from amino acid parts, but many (all?) seem to have disappeared. Commercialization opportunity?
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Appreciate this perspective—encouraging yet realistic about the tough funding landscape. Also, being open to shifting from basic to applied/translational research can reveal opportunities with more sustained support from diverse stakeholders.
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No cheating
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Orange seems to be winning the popularity contest
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Well done
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Nice work!