benadler.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Dive into our latest Microbe Matters 🦠 where Alison Criss talks about Neisseria gonorrhoeae, and if you find those micrographs super cool, you're not the only ones! 😊 www.nature.com/articles/s41...

submitted 11 hours ago • 0 comments

Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social

submitted 1 day ago • 3 comments

So happy to see this awesome work finally out in its final form! Congrats to Ben, Muntathar, and team!

submitted 1 day ago • 1 comment

🧪 #MicroSky #PhageSky

submitted 1 day ago • 0 comments

Phage genomes are an pool of untapped potential that could be harnessed to create new genomic tools. IGI's @jenniferdoudna.bsky.social & Brady Cress @cresslab.bsky.social detail a new method for exploring phage genomes, out today in @naturemicrobiol.bsky.social. Read more: ow.ly/uucL50V77n0 🧪🧬🦠

submitted 1 day ago • 1 comment

It is finally out! Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out @naturemicrobiol.bsky.social www.nature.com/articles/s41...

submitted 1 day ago • 7 comments

Looks like I'm reading Nature Plants today! 🌶️🌶️🌶️

submitted 1 day ago • 1 comment

East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research. news.berkeley.edu/2025/02/24/d...

submitted 2 days ago • 1 comment

Fascinating paper about the potential of phage for local drug delivery by Brian Hsu (Va Tech) and colleagues. (also nice acknowledgment for SeqCoast Genomics @seqcoast.bsky.social!) www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

Base-modified nucleotides mediate immune signaling in bacteria www.science.org/doi/abs/10.1... #jcampubs

submitted 7 days ago • 0 comments

Discovery of widespread activating mutations in a compact RNA-guided endonuclease https://www.biorxiv.org/content/10.1101/2025.02.11.637750v1

submitted 15 days ago • 0 comments

Happy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...

submitted 22 days ago • 3 comments

BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...

submitted 17 days ago • 65 comments

Phage defense and genome editing using novel retrons sourced from isolated environmental bacteria https://www.biorxiv.org/content/10.1101/2025.01.29.635429v1

submitted 29 days ago • 0 comments

Very excited to share the first story from my postdoc where we uncover the structural basis for slow Cas9 turnover! We use kinetics-guided cryo-EM to capture 25 conformational states of SpCas9 from a single dataset - including the first look at Cas9 releasing product. biorxiv.org/content/10.1...

submitted 91 days ago • 2 comments

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab! www.nature.com/articles/s41...

submitted 29 days ago • 4 comments

It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus rdcu.be/d7EsN

submitted 31 days ago • 4 comments

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

submitted 35 days ago • 1 comment

Been waiting a long time to see this in print - phage proteins are capable of inhibiting immune systems across host-domain boundaries 🤯 Big congrats @erezyirmiya.bsky.social et al!!

submitted 35 days ago • 1 comment

Amazing work from @prywes.bsky.social ! A comprehensive dissection of the enzyme that fixes most of the carbon on earth. 🌿

submitted 36 days ago • 1 comment

Really exciting work by @prywes.bsky.social - analysis of the effect of all possible single amino acid variants on activity of a simple rubisco. Next step plant rubisco 😄? Big step towards improving carbon fixation www.nature.com/articles/s41...

submitted 36 days ago • 1 comment

OpenAI working on a longevity foundation model www.technologyreview.com/2025/01/17/1...

submitted 40 days ago • 0 comments

New lab paper alert: Presenting "Prophage-DB", a database of prophages mined from public databases along with metadata. environmentalmicrobiome.biomedcentral.com/articles/10....

submitted 44 days ago • 1 comment

How can single-cell transcriptomics profile phage infection in individual microbial cells? Check out our preprint with Anika Gupta, Norma Morella, Dmitry Sutormin & other authors, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.biorxiv.org/content/10.1...

submitted 43 days ago • 0 comments

It’s true!! Pho Kolaches exist (Koffetia, Houston) @alisoncook.bsky.social

submitted 45 days ago • 2 comments

Excited to share our work using machine learning to predict anti-phage defense systems! 1/n

submitted 49 days ago • 2 comments

Just ... 🤯 What can't RNA do (with a little help from proteins)?

submitted 49 days ago • 1 comment

RNA-triggered CRISPR-Cas12a2 Preferentially and Cooperatively Cleaves Collateral DNA https://www.biorxiv.org/content/10.1101/2025.01.05.631166v1

submitted 53 days ago • 0 comments