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Practical considerations for accurate estimation of diffusion parameters from single-particle tracking in living cells https://www.biorxiv.org/content/10.1101/2025.06.12.659344v1

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Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor https://www.biorxiv.org/content/10.1101/2025.06.12.659357v1

submitted 4 hours ago • 0 comments

Enthalpy-Entropy Compensation https://www.biorxiv.org/content/10.1101/2025.06.10.658876v1

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Bringing the Genetically Minimal Cell to Life on a Computer in 4D https://www.biorxiv.org/content/10.1101/2025.06.10.658899v1

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Hydration shells of globular and intrinsically disordered proteins: effects of amino acid composition, peptide conformation, and force fields https://www.biorxiv.org/content/10.1101/2025.06.10.658889v1

submitted 9 hours ago • 0 comments

Constrained template matching using rejection sampling https://www.biorxiv.org/content/10.1101/2025.06.10.658890v1

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Condensate-driven chromatin organization via elastocapillary interactions https://www.biorxiv.org/content/10.1101/2025.06.12.659369v1

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Formation of extracellular vesicles depends on mechanical feedback of the cortex and the glycocalyx https://www.biorxiv.org/content/10.1101/2025.06.14.659723v1

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Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets https://www.biorxiv.org/content/10.1101/2025.06.13.659650v1

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A lipid plug affects K2P6.1(TWIK-2) function https://www.biorxiv.org/content/10.1101/2025.06.11.659167v1

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ParB C-terminal lysine residues are essential for dimerization, in vitro DNA sliding and in vivo function https://www.biorxiv.org/content/10.1101/2025.06.10.659001v1

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Parameter Optimization for Iterative MINFLUX Microscopy enabled Single Particle Tracking https://www.biorxiv.org/content/10.1101/2025.06.10.658837v1

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Kinetic asymmetry drives kinesin-1's unidirectional and processive movement https://www.biorxiv.org/content/10.1101/2025.06.11.659012v1

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Magnetic Particle Imaging Lymphography (MPIL): A novel technique for lymph node mapping https://www.biorxiv.org/content/10.1101/2025.06.11.658392v1

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DNA origami-based platform for multi-axial single-molecule force spectroscopy reveals hidden dynamics in Holliday junctions https://www.biorxiv.org/content/10.1101/2025.06.10.658941v1

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Backbone Rigidity Encodes Universal Viscoelastic Signatures in Biomolecular Condensates https://www.biorxiv.org/content/10.1101/2025.06.10.658939v1

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A computational analysis of the glycoprotein LRP1 structure and the role of glycans as quaternary glue https://www.biorxiv.org/content/10.1101/2025.06.10.658798v1

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Conformational dynamics of the active state of β-arrestin 1 https://www.biorxiv.org/content/10.1101/2025.06.10.658911v1

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A fluorescent probe for the enzymatic activity of KATP https://www.biorxiv.org/content/10.1101/2025.06.10.658839v1

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MMP release following cartilage injury leads to collagen loss in intact tissue - a computational study https://www.biorxiv.org/content/10.1101/2025.06.10.658780v1

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The bacterial ESCRT-III PspA rods thin lipid tubules and and increase membrane curvature through helix α0 interactions https://www.biorxiv.org/content/10.1101/2025.06.13.659447v1

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Biophysics of the Coronavirus-Membrane Interaction: Role of Nonequilibrium Binding Energy https://www.biorxiv.org/content/10.1101/2025.06.10.658990v1

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Polyanionic Non-Collagenous Proteins and Their Analogues Promote Artificial Mineralization of Embryonic Mouse Bone https://www.biorxiv.org/content/10.1101/2025.06.10.658745v1

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On the potential sources of a low-frequency sound percept only a few can hear https://www.biorxiv.org/content/10.1101/2025.06.07.658448v1

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Magellon - an extensible platform for cryo-EM data visualization, management, and processing https://www.biorxiv.org/content/10.1101/2025.06.09.658726v1

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Oblique Thick Light-Sheet Microscopy with Spatiotemporal 3D Localization for RNA Imaging in Intact 50 μm-Thick Sections https://www.biorxiv.org/content/10.1101/2025.06.09.658547v1

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Two peas in a pod: retroviral RNA dimers organize Gag-RNA nanoclusters with novel biophysical properties https://www.biorxiv.org/content/10.1101/2025.06.09.658653v1

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Controlling Multicomponent Condensate Morphology via Additive-Modulated Interactions https://www.biorxiv.org/content/10.1101/2025.06.09.658693v1

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Pathogenic BRCA1 mutations disrupt allosteric control by BARD1 https://www.biorxiv.org/content/10.1101/2025.06.07.658438v1

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Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1

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Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating https://www.biorxiv.org/content/10.1101/2025.06.10.657059v1

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Constitutive activation and allosteric mechanisms underlying Gi/Gq signaling bias in SUCNR1 revealed by AlphaFold-based modeling and enhanced sampling simulations https://www.biorxiv.org/content/10.1101/2025.06.08.658530v1

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The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior https://www.biorxiv.org/content/10.1101/2025.06.06.658390v1

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Multiphasic Organization and Differential Dynamics of Proteins Within Protein-DNA Biomolecular Condensates https://www.biorxiv.org/content/10.1101/2025.06.09.658691v1

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Prediction of physical characteristics of disordered proteins using molecular simulation and physics-informed multiple machine learning strategies https://www.biorxiv.org/content/10.1101/2025.06.09.658593v1

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Nucleation Landscape of Biomolecular Condensates in the Grand Canonical Ensemble via Monte Carlo Simulations https://www.biorxiv.org/content/10.1101/2025.06.06.658304v1

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Conformational Landscaping and Dynamic Mutational Profiling of Binding Interactions and Immune Escape for Broadly Neutralizing Class ... https://www.biorxiv.org/content/10.1101/2025.06.07.658468v1

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Distinct substrate and intermediate recognition via mutation effects on Mycobacterium tuberculosis methionyl-tRNA synthetase https://www.biorxiv.org/content/10.1101/2025.06.06.658285v1

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Observing intersubunit dynamics in single yeast ribosomes https://www.biorxiv.org/content/10.1101/2025.06.05.658109v1

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Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement https://www.biorxiv.org/content/10.1101/2025.06.06.658200v1

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A light-weight segmentation method for multi-state Brownian trajectories https://www.biorxiv.org/content/10.1101/2025.06.05.658053v1

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Linker Length and Composition within Disordered Binding Motifs modulates the Avidity and Reversibility of a Multivalent Protein Interaction Switch https://www.biorxiv.org/content/10.1101/2025.06.06.658374v1

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Structural Acrobatics of IAA7: Exercising Fuzzy Regions to Aid Auxin-Mediated Catalysis https://www.biorxiv.org/content/10.1101/2025.06.08.657175v1

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Biological Processes as Exploratory Dynamics https://www.biorxiv.org/content/10.1101/2025.06.06.657857v1

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Branching, crosslinking and decentralization of microtubules accelerates intracellular assembly https://www.biorxiv.org/content/10.1101/2025.06.05.658035v1

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ProGuide: a flexible framework for modeling global conformational rearrangements in proteins using DEER-derived distance restraints https://www.biorxiv.org/content/10.1101/2025.06.05.658127v1

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Neck-region-microtubule interactions direct counterclockwise stepping of kinesin-1 https://www.biorxiv.org/content/10.1101/2025.06.07.658466v1

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Formation of a μ-oxo nucleophile enables efficient hydrolysis by a trinuclear metal center in Family II inorganic pyrophosphatase https://www.biorxiv.org/content/10.1101/2025.06.08.658471v1

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Long-range actin-driven endosymbiont mobility in a deep-diverging bilaterian https://www.biorxiv.org/content/10.1101/2025.06.08.658386v1

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A facile and reproducible method for the purification of peptide- and protein-functionalized DNA nanostructures https://www.biorxiv.org/content/10.1101/2025.06.08.658483v1

submitted 7 days ago • 0 comments