borissieber.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc

submitted 10 hours ago • 0 comments

Do not miss the #membrane seminars this THU! As usual zoom link and info here felixcampelo.wixsite.com/membranetraf... or via the mailing list lists.icfo.es/mailman/list... @felixmendu.bsky.social @ishier.bsky.social

submitted 16 hours ago • 0 comments

[BC]² Basel Computational Biology Conference 2025 will take place on 8-10 September. The conference brings together over 500 international scientists from academia, industry, and healthcare to explore advancements at the intersection of #bioinformatics and artificial intelligence. See bc2.ch

submitted 13 days ago • 1 comment

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

submitted 1 day ago • 1 comment

Use this form to tell us how the new US administration is affecting your research, or suggest future coverage https://go.nature.com/3EYNA8C

submitted 2 days ago • 4 comments

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

submitted 17 days ago • 1 comment

🚨Long term postdoc position available on the reconstitution of lipid kinases!🚨 Do you have a passion for protein reconstitution and lipid signalling? You will reconstitute lipid kinases from eukaryotic expression systems to determine their kinetic regulation. www.jobs.ac.uk/job/DLW981/r...

submitted 3 days ago • 0 comments

🔎 Looking to start a PhD in Sept 2025? The Crick Institute spring round for PhD recruitment is open! If you are interested in actin cytoskeleton and imaging 🔬 then check out my project on role of Arp2/3 iso-complexes in regulating invadopodia👇please RT www.crick.ac.uk/careers-stud...

submitted 4 days ago • 0 comments

You are passionate about mobile DNA, structural biology, and genome engineering? 👀 Exciting #postdoc opportunity ahead! @irmaquerques.bsky.social's lab is seeking a postdoctoral researcher with a background in biochemistry and structural biology (cryo-EM) 🥼 More ➡️ tinyurl.com/nd9zbmt6

submitted 6 days ago • 0 comments

Have you ever thought of using a fluorescent probe to specifically enrich and profile proteins with disordered regions? Read below about RUBICON (reactive unfolded protein-based identification of cysteine on enrichment), a new workflow which enables the identification of the disordered proteome!

submitted 6 days ago • 0 comments

PomBase is GBC Global BioData Resource of the week www.linkedin.com/pulse/pombas...

submitted 7 days ago • 0 comments

Have you produced beautiful images as part of your cell biology research? Then enter our image competition: bscb.org/competitions... Deadline 1st March Check out last year's winning picture from Liam Hill at Cardiff university showing actin staining in the bronchial tree

submitted 7 days ago • 0 comments

The answer is yes! Come hear about STARLING this afternoon at the Biophysical Society IDP subgroup symposium! Thread to follow later today... www.biorxiv.org/content/10.1...

submitted 9 days ago • 0 comments

Now seems a good time to mention that I haven't yet filled a postdoc position in phylogenetic methods. If you just lost your job, need something temporary, and know something about bioinformatics/statistics/evolution, talk to me.

submitted 9 days ago • 3 comments

Interested in imaging protein suprastructures and membranes dynamics in situ? You also happen to be preoccupied by the exocyst? Read our latest preprint where we time-resolved the choreography of a flexible exocyst higher-order structure and the vesicle in exocytosis www.biorxiv.org/content/10.1...

submitted 12 days ago • 1 comment

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

submitted 14 days ago • 15 comments

🔬 Excited to share our latest paper! We’ve found how Spd-2 coordinates with Polo and Aurora A to build critical scaffolds in centrosome assembly in Drosophila. 🧬 www.science.org/doi/10.1126/...

submitted 14 days ago • 0 comments

Soooo excited to share this, just published. www.nature.com/articles/s41.... It started as a crazy ‘Friday afternoon’ experiment and just… worked. And kept on working. We fused a #nanobody to a #thioesterase. This delivers the thioesterase to a target and specifically depalmitoylates this protein

submitted 17 days ago • 2 comments

Exciting news! Our latest paper reveals that Spd-2 (CEP192) recruits Polo & Aurora A to build two scaffolds—Polo-dependent Cnn (for strength) & Aurora A–dependent TACC (for protein concentration)—crucial for centrosome assembly in Drosophila. #CellBiology #Centrosome www.science.org/doi/10.1126/...

submitted 16 days ago • 2 comments

Happy to share our paper’s final version on the evolution, structure, and membrane binding / remodeling of Asgard ESCRT-III proteins! And my first 🦋 post! www.science.org/doi/10.1126/...

submitted 16 days ago • 1 comment

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

submitted 17 days ago • 1 comment

Hello, Bluesky! ☀️ We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late. Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

submitted 17 days ago • 43 comments

Anyone out in BlueSky land work with Aspergillus, that does MIC testing? We have a drug we want to test... #Collaboration #FungalResistance

submitted 18 days ago • 2 comments

Happy to share our new study showing that the Ub E3 ligase SIAH1, known to dimerise via its C-term SBD, also dimerises via its N-term RING. When these tendencies combine, full-length SIAH1 forms multimers, which might explain its clustering in cells & preference for aggregated/multimeric substrates.

submitted 18 days ago • 4 comments

📢New Actin Probe available at Spirochrome! Introducing SPY650-FastAct_X our latest actin probe with highly improved kinetics and no toxicity! spirochrome.com/product/spy6... The product is now available from our distributors Preprint from the @kjohnsson.bsky.social lab: doi.org/10.1101/2025...

submitted 18 days ago • 3 comments

We are looking for a postdoc in bioinformatics interested in broad questions about the ecology and evolution of host-associated microbiomes using social bees as model. Please share with potential candidates and if interested apply here: career5.successfactors.eu/career?caree...

submitted 19 days ago • 0 comments

The EMBO ESCRT meeting 2025 #EMBOescrt is open for registration: meetings.embo.org/event/25-escrt Please share the info around you, and see you in Montreux!

submitted 19 days ago • 0 comments

The SIB Swiss Institute of #Bioinformatics is on Bluesky! We’re a non-profit organization dedicated to biological & biomedical #dataScience, supporting research & innovation. Follow us for updates on personalized health, biodiversity, pathogens, open science and more. Visit us at sib.swiss

submitted 20 days ago • 0 comments

MC4R regulates #BodyWeight at hypothalamic neuronal #cilia, but its levels are normally v low. @nachury.bsky.social &co show that MC4R accumulation is prevented via continuous ubiquitin- & β-arrestin-dependent exit from cilia, unless MC4R is inhibited by AgRP 🧪 @plosbiology.org plos.io/40MWUUz

submitted 20 days ago • 0 comments

First Post! Thrilled to share our lab's first evolutionary cytoskeleton study! We uncover two distinct FtsZ paralogs in Odinarchaeota OdinFtsZ1 forms curved filaments, while OdinFtsZ2 assembles into spiral rings. A glimpse into tubulin evolution! threads👇 #Eukaryogenesis #AsgardArchaea #cytoskeleton

submitted 20 days ago • 1 comment

To all my #cebtriole/#flagella/#cilia colleagues ! Anyone seen a protein localizing only to one of two flagella ?

submitted 22 days ago • 1 comment

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

submitted 24 days ago • 12 comments

Don’t forget to apply! This is an amazing opportunity!

submitted 23 days ago • 1 comment

Arp2/3 nucleates bidirectional linear actin filaments when activated by SPIN90 !!! www.biorxiv.org/content/10.1...

submitted 24 days ago • 0 comments

Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky journals.plos.org/plosbiology/...

submitted 25 days ago • 10 comments

Wow! We got the cover! #MBOC #ASCB #CellBio So proud of #TeamTestis. Screening <270 lines for shape defects was a huge team effort! I created this collage from the team’s images from the past 2 years! Depth-color-coded with Fiji. Inspired by late 19th century lithographic animal illustrations.

submitted 25 days ago • 6 comments

🚨🚨 MEGA JOB ALERT 🚨🚨 Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social! Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏 More details below... check it out! 🧵 1/3

submitted 26 days ago • 1 comment

A must read for #gpcr #science folks: Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex www.nature.com/articles/s41...

submitted 27 days ago • 0 comments

🚀 We're a group of passionate postdocs at University of Geneva fostering scientific exchange & career growth! Join us for events like Postdoc Day, Biology Club seminars, & social apéros. Got ideas? Let’s make them happen! 🌟 Explore more: www.unige.ch/apdu/ #PostdocLife #UNIGE

submitted 27 days ago • 0 comments

Super important resource! And worth raising awareness, especially given the uncertainties at the NIH (although it would still be devastating if PubMed went down)🧪

submitted 27 days ago • 0 comments

Question: Does anyone have any good suggestions for a genetically encoded tension sensor to express in cells? Something like a cortical tension sensor or cell-cell tension sensor. I can't use dye like Flipper. Thank you. #question #biosensor

submitted 28 days ago • 1 comment

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

submitted 28 days ago • 1 comment

More than ever, researchers need to explain how they use taxpayer money to provide tangible benefits. I'll start: My lab has developed a completely novel way to make cellular therapies a lot more effective. Our approach shows promising results in pancreatic, ovarian and lung cancer.

submitted 29 days ago • 16 comments

Interested in activating kinases, protein biochemistry & enzymology? We’re looking for a creative #postdoc to join @annebertolotti.bsky.social investigating innovative approaches to increase cellular resistance to diverse diseases. Apply by 16 FEB www.nature.com/naturecareer... #PostdocJobs

submitted 31 days ago • 0 comments

POSTDOC POSITION AVAILABLE, Geneva, Switzerland - Applications are invited for a postdoc position to study UV-B perception and signalling in plants. Please apply, forward to suitable candidates, and/or repost; many thanks! Deadline February 24, 2025. See www.ulm-lab.ch for more information.

submitted 32 days ago • 0 comments

This paper is very cool. It's great to see others taking FerriTagging to a new level. If you're curious about the method see here: www.nature.com/articles/s41...

submitted 33 days ago • 0 comments

📢 #Yeast2025 21-24 July 2025 in Paris @sorbonne-universite.fr Join us at the 32nd ICYGMB and enjoy the gala dinner aboard the Bateaux Mouches on the river Seine ⚓ Registration premc.org/yeast2025/re...

submitted 33 days ago • 0 comments

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

submitted 34 days ago • 0 comments