brunetlab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging. www.legacy.com/us/obituarie...

submitted 12 days ago • 3 comments

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab www.biorxiv.org/content/10.1...

submitted 44 days ago • 1 comment

I'm giving a talk tomorrow morning about my book ("How We Age"). But the slides already feel out of date because 1) there are so many new stories in the field, and 2) science as we know it is being destroyed, so the pipeline from ideas to drugs will dry up soon. Sigh

submitted 7 days ago • 0 comments

A few days late, but I’m happy to post our recent publication on body-to-brain signaling regulation of memory in Nature Aging:

submitted 7 days ago • 2 comments

KODAMA goes spatial. doi.org/10.1101/2025... #spatialtranscriptomics #visium #visiumhd #seurat #giotto

submitted 9 days ago • 0 comments

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July. We'll work at the intersection of statistical genetics, population genetics, and machine learning.

submitted 9 days ago • 32 comments

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

submitted 10 days ago • 3 comments

Memory loss in aging - what are the mechanisms and can they be reversed? A fascinating conversation with @ctmurphy1.bsky.social youtu.be/To5KFveFm9c?...

submitted 11 days ago • 1 comment

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

submitted 13 days ago • 4 comments

www.cell.com/stem-cell-re...

submitted 17 days ago • 0 comments

We—Nicolas @rohner.bsky.social, Lauren @lsaunders.bsky.social, Arica @abeisaw.bsky.social & Sepand @rastapopolus.bsky.social—are planning the first German #fish ( #zebrafish, #medaka, #killifish, others) #meeting for September 2026. If you're a PI & want info, get in touch!

submitted 18 days ago • 2 comments

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

submitted 19 days ago • 1 comment

Benayoun lab team members Clayton Baker, Minhoo Kim, Aaron Lemus (with photobomb from Victor Ansere) and Ryan Lu rocking Poster session#1 at #AGE2025 in Anchorage! ❤️❤️ #USCLeonardDavis #EarlyCareer #ProudMentor

submitted 29 days ago • 0 comments

🧪 #neurology #neuroskyence tinyurl.com/bp5d8386 Another beautiful example of NIH-SPONSORED bedside to bench and back to bedside work from an outstanding clinician scientist. This work is producing some of the most compelling responses to treatment in what is arguably the worst pediatric brain tumor.

submitted 21 days ago • 0 comments

Congratulations to our 2025 Catalyst Momentum awardees! Their projects explore how sleep, inflammation, endocannabinoid metabolism, cellular stress, microglia, and other factors shape brain aging and resilience. Learn more: brainresilience.stanford.edu/news/fueling...

submitted 20 days ago • 0 comments

www.harvard.edu

submitted 24 days ago • 0 comments

It was so much fun to discuss why we do basic science. "If we understand how biology works, then lots of useful applications will come out of it ... But honestly, that’s not the only thing that drives people. People are just curious, and they want to know how living systems work." #Celegans 🧪🧬🪱

submitted 26 days ago • 1 comment

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

submitted 28 days ago • 1 comment

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n

submitted 28 days ago • 15 comments

FaceAge, a deep learning system to estimate biological age from face photographs to improve prognostication: a model development and validation study - The Lancet Digital Health www.thelancet.com/journals/lan...

submitted 30 days ago • 0 comments

Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇

submitted 33 days ago • 5 comments

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration www.biorxiv.org/content/10.1...

submitted 46 days ago • 1 comment

How to target aging? Exciting Fusion meeting "Interventions in Aging" in October!! www.fusion-conferences.com/conference/1...

submitted 49 days ago • 0 comments

🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...

submitted 49 days ago • 6 comments

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

submitted 51 days ago • 2 comments

Our latest work now online in Cell: Rewriting regulatory DNA to dissect and reprogram gene expression Our new method (Variant-EFFECTS) uses high-throughput prime editing + flow sorting + sequencing to precisely measure effects of noncoding variants on gene expression Thread 👇

submitted 55 days ago • 1 comment

We've made remarkable progress in the science of aging (geroscience) with readiness to apply this for "precision geromedicine." A brilliant new review @cellpress.bsky.social www.cell.com/cell/fulltex...

submitted 53 days ago • 5 comments

🎈Our latest 🪅 We know that in addition to exteroceptive mechanisms, interoceptive chemosensation is also critical for regulating physiology/behavior. We find that an enteric neuron in worms senses ingested salts via a variant ionotropic receptor (IR like the fly IRs) to regulate salt stress. 1/n

submitted 54 days ago • 7 comments

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

submitted 56 days ago • 0 comments

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out! We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections! www.nature.com/articles/s41...

submitted 58 days ago • 1 comment

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

submitted 63 days ago • 15 comments

After 7 years, thrilled to finally share our #MICrONS functional connectomics results! We recorded activity from ~75K neurons in the visual cortex of a single mouse, then mapped its wiring using electron microscopy. nature.com/immersive/d42859-025-00001-w/index.html

submitted 62 days ago • 1 comment

Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects. www.science.org/doi/10.1126/...

submitted 61 days ago • 1 comment

Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans. By @y1fanyang.bsky.social , out now @naturecomms.bsky.social www.nature.com/articles/s41...

submitted 61 days ago • 1 comment

Fancy visiting Malta to hear all the newest research on all things #Aging? Register today & submit an abstract to join Henri, Linda, @willmair.bsky.social and our fantastic speaker lineup! ☀️#FusionAging25 📅Early Bird & Talk Deadline: 24 April 2025 🔗Conference Website: bit.ly/4i8RhGE

submitted 62 days ago • 1 comment

🧪 I will have much more to write about this in a day or two, but for those following this story, please read the paper AND the public peer review comments!: doi.org/10.7554/eLif... 🧪 #Celegans

submitted 63 days ago • 3 comments

📣 103 participants and counting… The 2025 Nothobranchius Symposium is fast approaching! 🧬 Join us in beautiful Jena, Germany, June 5–6, 2025, for cutting-edge talks on #killifish. 📝 Abstracts accepted until April 22 🔗 notho-2025.de We look forward to meeting you at #Notho25!

submitted 65 days ago • 0 comments

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

submitted 69 days ago • 2 comments