cresslab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

📣Taking our ability to understand phage biology up a notch. Phage functional genomics platform, out now 🔓Open access, read it at your leisure www.nature.com/articles/s41... @cresslab.bsky.social, @naturemicrobiol.bsky.social

submitted 10 hours ago • 0 comments

Excited to share our new preprint on mutational scanning of the TnpB RNP! We identify several highly activating, single-position mutations in TnpB’s protein and reRNA. These datasets enabled us to engineer enhanced TnpB protein variants (>50x plant editing levels compared to WT).

submitted 19 hours ago • 1 comment

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d | Nature Microbiology https://www.nature.com/articles/s41564-025-01935-7

submitted 5 days ago • 0 comments

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓) We decided to call them TIGR-Tas systems 🐯

submitted 3 days ago • 2 comments

Huge work from @benadler.bsky.social et al @cresslab.bsky.social; Glad to be part of this super cool work.

submitted 5 days ago • 0 comments

It's kind of A Day as far as awful distracting things, but at least there is science!!!!

submitted 5 days ago • 0 comments

Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of

submitted 5 days ago • 3 comments

Fascinating read by Hope Henderson about exploring phage genomes: innovativegenomics.org/news/tool-ph...

submitted 6 days ago • 0 comments

A fun outing with the Rubin lab! @therubinlab.bsky.social

submitted 6 days ago • 0 comments

So happy to see this awesome work finally out in its final form! Congrats to Ben, Muntathar, and team!

submitted 6 days ago • 1 comment

Flashy words like "revolutionize" are thrown around quite liberally in our field. In this case though, I can't think of a more appropriate word. This stuff is 🔥🔥🔥.

submitted 6 days ago • 1 comment

🧪 #MicroSky #PhageSky

submitted 6 days ago • 0 comments

Dive into our lab’s first peer-reviewed publication—co-led with our friends @benadler.bsky.social and Muntathar Al-Shimary from the @doudna lab! If you’ve already read the preprint, don’t miss the new updates: doi.org/10.1038/s415... @naturemicrobiol.bsky.social

submitted 6 days ago • 3 comments

Phage genomes are an pool of untapped potential that could be harnessed to create new genomic tools. IGI's @jenniferdoudna.bsky.social & Brady Cress @cresslab.bsky.social detail a new method for exploring phage genomes, out today in @naturemicrobiol.bsky.social. Read more: ow.ly/uucL50V77n0 🧪🧬🦠

submitted 6 days ago • 1 comment

🧬OUT NOW Functional Genomics of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi by @benadler.bsky.social @doudna-lab.bsky.social @cresslab.bsky.social www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

It is finally out! Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out @naturemicrobiol.bsky.social www.nature.com/articles/s41...

submitted 6 days ago • 7 comments

East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research. news.berkeley.edu/2025/02/24/d...

submitted 7 days ago • 1 comment

We were proud to host Reps. @replsimon.bsky.social and @reptedlieu.bsky.social for a tour of the IGI and discussions on the #BiomedicalResearch we're doing with the support of funding from NIH! Here's a great article on the visit from the @ucberkeleyofficial.bsky.social news room: bit.ly/4gWtlpD 🧪🧬

submitted 6 days ago • 0 comments

A network of coiled-coil and actin-like proteins controls the cellular organization of magnetosome organelles in deep-branching magnetotactic bacteria | bioRxiv https://www.biorxiv.org/content/10.1101/2025.02.24.639979v1

submitted 7 days ago • 0 comments

Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...

submitted 7 days ago • 3 comments

Roche's SBX sequencing by expansion - preprint out! www.biorxiv.org/content/10.1...

submitted 7 days ago • 3 comments

www.sfchronicle.com/politics/joe...

submitted 9 days ago • 0 comments

Grateful to @replsimon.bsky.social & @reptedlieu.bsky.social for visiting IGI to learn how federal funding is critical to supporting cutting-edge science & medicine, as well as training future generations. Cutting science funding affects real families across the US. Read here: shorturl.at/8cqRh

submitted 10 days ago • 1 comment

Glad to welcome Democratic Vice Chair @tedlieu.bsky.social to CA-12 today. We toured labs at @ucberkeleyofficial.bsky.social and discussed how the Trump administration's attacks on NIH funding endangers decades of leading research and scientific work.

submitted 10 days ago • 3 comments

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

submitted 11 days ago • 5 comments

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...

submitted 11 days ago • 9 comments