Profile avatar
crystalline-entity.bsky.social
Running a Structural Biology and Protein Production group at a Boston biotech. Previously worked in rare disease, but focusing on drug discovery in precision oncology the last few years. Crystallography with a splash of CryoEM and NMR. Opinions are my own.
45 posts 552 followers 582 following
Prolific Poster
Posts 41 Comments 8

BREAKING: Reports that Trump would try to cut NIH's budget by 40% have come true. The request released moments ago would: - Cut $18 BILLION to NIH's $47b budget - Eliminate NIMHD, NCCIH, FIC - Collapse ICs into five 'focus areas' There's also a long screed about NIH's deficiencies.

submitted 1 day ago • 11 comments

353 signatories so far on the @aacu.org Call! AMAZING work by their team. Take a look - organized by the presidents' last names (not the institutions or associations). Is your college/university or academic organization there? #academicsky #skystorians #edusky #higher www.aacu.org/newsroom/a-c...

submitted 9 days ago • 6 comments

First post here- Hello Bluesky! Quick science query: These 2D classes are from negative stain of a FLAG pulldown (HEK cell eluate). Does this look like a real complex or a common contaminant? Would live to hear from anyone who’s worked on similar prep! #negativestainEM #pulldown #HEKcells

submitted 12 days ago • 0 comments

ScienceGuardians, where disgruntled authors complain about PubPeer A new BSky account that promises some big reveals about PubPeer users, but never delivers. Instead, it spews false accusations and conspiracy theories. Read my blog post: scienceintegritydigest.com/2025/04/18/s...

submitted 12 days ago • 4 comments

Sources have shared 2 important pieces of information about NIH grant payments (although I am trying to get further confirmation). Hang on... (1) ALL payments to Columbia, Brown, Northwestern, Cornell, Weill-Cornell, Harvard are frozen. 1/3

submitted 14 days ago • 9 comments

"The proposal would reduce the more than $47 billion budget of the NIH to $27 billion — a roughly 40 percent cut. It would consolidate NIH’s 27 institutes and centers into just eight."

submitted 16 days ago • 8 comments

Here is an up to date list of Big Law collaborators along with how much in free legal services they have pledged to Trump's causes. Paul Weiss 40M Cadwalader 100M Milbank 100M Skadden Arps 100M Willkie Farr 100M A&O Shearman 125M Kirkland & Ellis 125M Latham & Watkins 125M Simpson Thacher 125M

submitted 21 days ago • 1558 comments

US students. Looking to apply to graduate school? Had an offer rescinded recently? The University of British Columbia in Canada will re-open the application portal in some departments for US students from April 14-18. Details: www.grad.ubc.ca/us-applicant... #ubc #AcademicSky #PhDSky #ScienceSky

submitted 22 days ago • 14 comments

University presidents, the time is now! Unshackle the general counsel's office! File all the lawsuits! Release the faculty upon the op-ed sections! Write to your alumni, parents, and donors! You have nothing to lose but a tiny percentage of your enormous endowments... www.nytimes.com/2025/04/08/u...

submitted 24 days ago • 22 comments

Scientists should try to repeat more studies, but not those looking for a link between vaccines with autism - the replication studies were done and found that there is, in fact, no link between vaccines and autism. theconversation.com/scientists-s...

submitted 25 days ago • 8 comments

THIRD GRADERS. 8 or 9 years old.

submitted 26 days ago • 15 comments

Is this referring to the 'final' game for Porter?

submitted 27 days ago • 0 comments

Hands Off Protest in the Boston Common

submitted 28 days ago • 174 comments

I have never seen anything like this in NYC. 5th Ave covered from 42nd St well to the 20s. Nobody prepared for this volume. Volunteers are holding the traffic on all the side streets. No police in sight. #handsoff

submitted 28 days ago • 1030 comments

Great crowd at #HandsOff Boston

submitted 28 days ago • 0 comments

abcnews.go.com/Health/2000-...

submitted 28 days ago • 0 comments

Come for the protest and stay for the #DropkickMurphys! Protest rally begins Saturday at 11am. #HandsOffAmerica #HandsOffMassachusetts #HandsOffBoston

submitted 31 days ago • 4 comments

I may be tired and a little hoarse, but as I said again and again on the Senate floor, this is a moment where we cannot afford to be silent, when we must speak up.

submitted 31 days ago • 10898 comments

Several hundred people gathered at the Federal building in Boston to demand that Rumeysa Ozturk and ALL the prisoners being held illegally be released. 1/?

submitted 31 days ago • 1 comment

The CDC Has Been Gutted. -the scale of this is beyond stupid and it's execution beyond mean. This is an epically dumb own-goal that will cause far more harm than its paltry savings could ever offset. www.wired.com/story/cdc-gu...

submitted 31 days ago • 8 comments

. @scottgottliebmd.bsky.social and Pharma in general were fucking warned. Good luck getting your shit approved now you quiet ass bitches.

submitted 32 days ago • 6 comments

“The FDA as we know it is finished.” -Robert Califf The institutional knowledge lost today will likely slow approvals and hinder access. People will die preventable deaths.

submitted 32 days ago • 0 comments

Tariffs get all the attention, but ask economists what they're really worried about and many will point to the Trump administration's cuts to federal support for the sciences, including canceling grants and revoking student visas. #EconSky www.nytimes.com/2025/03/31/b...

submitted 33 days ago • 35 comments

Finally beginning to see a more overt shift in biotech attitude towards this administration as attacks add up. Peter Mark’s exit is affecting confidence across biotech and investors. Hoping to see more industry scientists publicly fight back like academics have been. endpts.com/biotech-mark...

submitted 33 days ago • 0 comments

So we can start planning Obama’s third-term campaign against him, right?

submitted 33 days ago • 0 comments

NIH has rescinded its scientific integrity policy. Hard to see this as anything other than clearing the way for shoddy research on things like vaccines. Regardless of the rationale, it's bad news for public health. grants.nih.gov/grants/guide...

submitted 34 days ago • 122 comments

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

submitted 37 days ago • 16 comments

Hope Massachusetts does the same.

submitted 36 days ago • 0 comments

1/ No matter how fucked up and illegal you thought the random detention and RENDITION of men who the government claimed were violent gang members was... @isabelaalhadeff.bsky.social and @nlanard.bsky.social are here to show you it's so much worse: www.motherjones.com/politics/202...

submitted 37 days ago • 11 comments

The censorship regime of Jay Bhattacharya

submitted 37 days ago • 14 comments

JFC, Fulbright scholar not accused of any crime, no immigration violation, no reason to expect any violence -- just Marco Rubio's whim -- and instead of summoning her first step is no-uniform / no-ID guys in masks and hoodies grabbing her off a public street.

submitted 38 days ago • 49 comments

Gee, I wonder what that study on vaccines and autism will show www.washingtonpost.com/health/2025/... "Geier and his father, Mark Geier, have published papers claiming vaccines increase the risk of autism, a theory that has been studied for decades and scientifically debunked."

submitted 38 days ago • 38 comments

The NCI grant supporting the Columbia comprehensive cancer center was terminated. Tell me how terminating support for cancer research helps the economy. taggs.hhs.gov/Content/Data...

submitted 45 days ago • 22 comments

This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH

submitted 49 days ago • 736 comments

As someone who donated a lot to Democrats over the years: I have cut off funding to all Democrats and the Democratic Party until their leaders show up ready to fight for us. You should, too. Go on @actblueorg.bsky.social and cancel any and all recurring contributions, no matter how small.

submitted 49 days ago • 52 comments

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

submitted 51 days ago • 26 comments

So to be clear, instead of just calling your senator and saying vote no on the CR, call them and say vote no on CLOTURE, and we are not too stupid to know the difference

submitted 52 days ago • 3 comments

Done and done.

submitted 52 days ago • 0 comments

Mahmoud Khalil should be at home with his pregnant wife. Instead, he's been illegally abducted & had his constitutional right to free speech & due process stripped. We're demanding his immediate release and we cannot allow this abuse of power to go unchecked. #FreeMahmoudKhalil

submitted 53 days ago • 451 comments

Republicans inherited one of the strongest stock markets in history and in 1 month they've fucked it all up.

submitted 54 days ago • 86 comments

This is an enormous mistake being made by our neighbors in NH. State vaccine programs are essential to ensure all children have access to life-saving vaccines. Small practices like my own would be unable to vaccinate kids without the help of the state program due to vaccine costs.

submitted 55 days ago • 2 comments