danielhurdiss.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...

submitted 1 day ago • 3 comments

"Molecular basis of host recognition of human coronavirus 229E" www.nature.com/articles/s41...

submitted 16 hours ago • 0 comments

Today's @usatoday.com front page First US death from measles in 10 years First child to die from measles in 22 years in the US All of this fully preventable

submitted 1 day ago • 470 comments

Host cell entry and neutralisation sensitivity of the emerging SARS-CoV-2 variant LP.8.1 Not every mutation or subvariant needs general attention. To explain the selection of them may need a repeat once in a while. www.thelancet.com/jo... 1/5

submitted 1 day ago • 1 comment

NEW #NOROVIRUS DATA: cases are still increasing, 29.4% higher than the previous 2-week period. 📈 People who have already had the virus this winter could be at risk again, as new data shows shift in circulating genotypes 1/2. Full report here 👇 www.gov.uk/government/s...

submitted 1 day ago • 2 comments

www.biorxiv.org/content/10.1... #teamtomo #cryoET

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Structure of the tilapia lake virus nucleoprotein bound to RNA pubmed.ncbi.nlm.nih.gov/39995042/ #cryoEM

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The @briggsgroup.bsky.social alongside teams from @uniheidelberg.bsky.social and @yalemicropath.bsky.social uncover elusive role of #HIV-1 component SP2. Detailed 3D views of viruses by #cryoEM show how SP2 helps the virus matrix to mature. ❕Read the paper @nature.com www.nature.com/articles/s41...

submitted 2 days ago • 0 comments

"Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display" pubs.acs.org/doi/10.1021/...

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Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...

submitted 4 days ago • 1 comment

Welcome to @ccpem.bsky.social on bluesky! The collaborative computing projection for #cryoEM provides support and software for the community!

submitted 4 days ago • 0 comments

"Norovirus replication, host interactions and vaccine advances" www.nature.com/articles/s41...

submitted 5 days ago • 0 comments

The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses. https://www.biorxiv.org/content/10.1101/2025.02.20.639337v1

submitted 7 days ago • 0 comments

Latest #virology research from the lab! 👇 Using genetic approaches and live-cell imaging, we show that the viral 2A protease plays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication. www.biorxiv.org/content/10.1...

submitted 5 days ago • 1 comment

After a short break from running, my preparations for the Utrecht Science Park 10K have begun! 🏃‍♂️ The real question is—can I beat the PhD candidates' times? 👀 @bobcoelingh.bsky.social @victorpisabarro.bsky.social

submitted 5 days ago • 1 comment

🚨 Amazing Opportunity 🚨 U Alberta is looking for a director for their new #cryoEM facility Support excellent researchers (who are really nice people) using state-of-the-art infrastructure. + reasonable cost of living + near some of most beautiful places in world + 🇨🇦 apps.ualberta.ca/careers/post...

submitted 6 days ago • 3 comments

Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase" www.nature.com/articles/s41... #cryoEM #StructuralBiology

submitted 7 days ago • 0 comments

#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

submitted 6 days ago • 2 comments

Nasal Sprays and Respiratory Infections - Microbial Minutes youtu.be/FRvo5SDZ7z4?... via @YouTube

submitted 7 days ago • 0 comments

schaechter.asmblog.org/schaechter/2... #MicroSky #PhageSky #CryoEM #CryoET #teamtomo

submitted 8 days ago • 0 comments

Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor pubmed.ncbi.nlm.nih.gov/39970913/ #cryoEM

submitted 8 days ago • 0 comments

Interesting: Canada is buying 500,000 doses of #GSK 's #H5N1 vaccine "as part of ... contingency planning to protect people who may be at increased risk of being exposed to the virus through [infected] animals." Wonder what would trigger a decision to use it? www.canada.ca/en/public-he...

submitted 9 days ago • 16 comments

Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid" #cryoEM #TRPV2 #TRPchannels www.nature.com/articles/s41...

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"Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses" www.pnas.org/doi/10.1073/...

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In @justinditrani.bsky.social final postdoc paper (with contributions from many others) we show that forming/purifying vesicles (here from M. smegmatis) allows structure det'n of endogenous membrane proteins in their native lipid bilayer 🧵 on methods & TB biology... www.pnas.org/doi/full/10....

submitted 9 days ago • 1 comment

Open #positions‼️ I am looking for: 📌2 Postdocs 📌 1 Research Assistant to join our new research group at the University of Milan. We’ll study #RSV viral replication factories and pioneer new protein degradation technologies #TPD as #antiviral strategies. If interested, drop me a message here 📩 🦠 RT

submitted 9 days ago • 0 comments

📢 Registration is now open for 'Wellcome-MRC Cryo-EM in Structural Biology 2025'! 📅 Join us online March 3-7 at @diamondlightsource.bsky.social @universityofleeds.bsky.social for lectures & demos in #CryoEM & #CryoET: sample prep, SPA, model building & more!🧬 🔗 www.diamond.ac.uk/Instruments/...

submitted 10 days ago • 0 comments

Our methods paper made it to bioRxiv: doi.org/10.1101/2025... Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5 #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM

submitted 9 days ago • 1 comment

OUT NOW: Structural insights into tecovirimat antiviral activity and poxvirus resistance @institutpasteur.bsky.social #microsky www.nature.com/articles/s41...

submitted 16 days ago • 0 comments

Thanks to all who attended the #BPS2025 #cryoem symposium yesterday, and the happy hour last night! We heard some superb science at the symposium and had some great discussions which were continued in the evening. And congratulations to Dr. Elizabeth Wright, our inaugural Almeida Award winner!

submitted 11 days ago • 1 comment

🌟 Join Institut Pasteur as a Junior Research Group Leader 🌟 Explore host-microbe interactions in key areas like vaccinology, infectious diseases, neuro-immunology, and maternal health. 📅 Deadline: Feb 28, 2025 (few weeks left!) Apply now ⬇️

submitted 14 days ago • 0 comments

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

submitted 16 days ago • 12 comments

Might just be the best package I've ever received from a collaborator. God bless the Belgians! 🇧🇪🍻

submitted 16 days ago • 1 comment

Our #CryoEM study on the binding of a Tarantula toxin to a full-length human voltage-gated sodium channel has been published. Very proud of the awesome people in my lab 🥳🥂 www.nature.com/articles/s41...

submitted 21 days ago • 1 comment

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions: Cell Reports www.cell.com/cell-reports...

submitted 24 days ago • 0 comments

Human case of highly pathogenic avian influenza virus H5N1 (genotype DI.2) infection in the United Kingdom. The person acquired the infection on a poultry [?, not stated] farm with a large number of infected birds, and is currently well. www.gov.uk/government/n...

submitted 32 days ago • 3 comments

Today we gathered over coffee and cake to thank Raoul de Groot for 40 years of service to the Utrecht Virology Lab 💐 Raoul is, quite literally, a giant in the coronavirus field, and we are extremely fortunate to work with him! 😄

submitted 32 days ago • 0 comments

We are very pleased to share our latest preprint on the architecture of the membrane complex of the type 7 secretion system involved in bacterial competition in B. subtilis. #CryoEM #microsky

submitted 33 days ago • 3 comments

The path of least resistance? #NMRchat #cryoEM #StructuralBiology

submitted 34 days ago • 2 comments

Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization pubmed.ncbi.nlm.nih.gov/39846739/

submitted 34 days ago • 0 comments

Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM www.science.org/doi/10.1126/...

submitted 35 days ago • 0 comments

Our joined effort with the the Maric Lab @hmariclab.bsky.social @uniwuerzburg.bsky.social on how to aggregate capsids of Hepatitis B virus inside cells is now out in Elife doi.org/10.7554/eLif... . #cryoEM 🧪❄️🔬

submitted 35 days ago • 0 comments

I'd like to draw your attention to this truly excellent paper from the Taraska lab on cryoET of plasma membrane associated proteins. Everyone who is thinking about probes in the cryoET space should also see what they could do with ferritag (fig 6) www.nature.com/articles/s41...

submitted 37 days ago • 11 comments

Welcome to Bluesky @astburycentre.bsky.social! 😄

submitted 36 days ago • 0 comments

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund

submitted 36 days ago • 2 comments

As we head into 2025, let's take one final look back at 2024 and how the year unfolded in the PDB archive. There were 15319 entries released last year but what more can we find out about those structures ⚖️? A thread 1/11 🧵

submitted 46 days ago • 1 comment

"Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines" www.nature.com/articles/s41...

submitted 38 days ago • 0 comments