davidusharauli.bsky.social
Immunologist & biotech startup co-founder (tregeutix.com) on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey 🚀
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Now, it's the 1938 Czechoslovakia moment. Let's see whether history repeats itself or takes an alternate path.
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Narrow-minded conservatives reacted similarly to Sulkhan-Saba Orbeliani when he returned to Georgia from Western Europe, where he had sought assistance in the 18th century. Therefore, he should take pride in being regarded as so significant.
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Georgia's situation is not unique. Hungary and Slovakia, both EU countries, share a similar ideology with Georgia's current ruling party.
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We don't even fully understand how the oldest adjuvant, alum, works. We can debate all night, but the fact remains: if you can't predict the outcome, you can't claim to know how it works.
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very funny.
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She could have at least outlined what ARPA-H has achieved, if anything, during her tenure. All this generic talk is pointless.
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The only explanation I can think of is that they too let go of so many experienced employees that no one remains to notice the difference.
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I did not realize it was a mouse study. I thought you were focused on ex vivo human lymph node organotypic culture developmental work.
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2/ Two decades ago, Immunological Reviews set the gold standard for writing reviews. However, today, almost no journals, including Immunological Reviews itself, adhere to this standard, with only a few individual papers standing out.
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3. "comparing the performance of the models in predicting accessibility differences at specific peaks with individual motif terms removed might reveal the terms (motifs) that were specifically associated with altered accessibility at those peaks."
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2. "Reassuringly, peaks within each cluster harboring those motifs had greater magnitude accessibility differences than all peaks in the cluster"
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Unfortunately, the study suffered from a lot of GIGO (garbage in, garbage out) data, almost as if the lab had grown so frustrated with it that they just dumped everything into it at once.
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6/ though the overall effect was less dramatic than anticipated.
The takeaway? IL-10 expression was a misleading distraction. Tregs have more tricks up their sleeves, Tregs are indispensable, but IL-10 is not.
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5/ Luckily, the study was rescued by developing another genetically modified mouse model that specifically eliminated IL-10-expressing Tregs. The results were as expected: these IL-10+ Tregs played a crucial role in protecting colonic tissue from excessive inflammation.
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4/ But here’s where things took an unexpected turn: deleting IL-10 in these Tregs had no effect on inflammation. Stuck at this roadblock, they attempted to link stable IL-10+ Tregs to changes in TCR signaling, but the connection was weak at best.
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3/ The study began with identifying IL-10-expressing Foxp3+ Tregs in the colon. The researchers then developed a method to track these IL-10+ Tregs, even those that had once expressed IL-10 in the past, ultimately identifying a stable population of long-term IL-10+ Tregs.
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2/ What’s interesting about this paper is that it took a lot of detours and nearly ended up in the "negative data" pile, collecting dust. It was only salvaged by the lab’s talent in generating all kinds of KO and transgenic mice. So, let’s dive in.
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What a strange time. With a stroke of a pen, it's erased, as if it was never important and never truly mattered to them.
#diversity
#science
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I fail to see the purpose of this study. Without a double-blind approach, how can we tell if the tumor vaccine is truly effective or just a coincidence?
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It's incredible that such a massive population movement somehow completely bypassed the Georgian language at the heart of the Caucasian mountains.