devdoot.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Delighted to share our paper where we describe the “Generalization of the sci-L3 method to achieve high-throughput linear amplification for replication template strand sequencing, genome conformation capture, and the joint profiling of RNA and chromatin accessibility”.

submitted 15 hours ago • 1 comment

Pathogen genomics central to response to the HPAI panzootic. Here, latest direct RNA nanopore sequencing improve consensus sequence generation, but latest DNA nanopore chemistry after RT and amplification outperforms native viral RNA sequencing. 👉 academic.oup.com/ve/advance-a...

submitted 2 days ago • 0 comments

Halfpipe, our tool for analyzing RNA-seq data from metabolic RNA labeling experiments, is out!!!🎉 Congratulations to Jason and the team including collaborators from @molgen.mpg.de and @uniklinik-fr.bsky.social ! The code is available on GitHub. #RNAseq #SLAMseq #RNAmetaboliclabeling

submitted 2 days ago • 0 comments

Last night I pointed my Seestar S50 telescope to the south and looked at some amazing objects. Nebulae, the Large Magellanic Cloud (top left), two more distant galaxies and one cluster C80. Processed in Lightroom (free). The night sky is full of wonders.

submitted 2 days ago • 1 comment

Struck by the desire to say "But CZI" and "But Altos" to illustrate science's capture by said elite. And yet, bless anyone keeping scientists employed (right?). It's always been hard. Haunted by the lack of moral clarity from a passage in a recent Warburg biography. Our elites remain benign, so far.

submitted 3 days ago • 0 comments

Deeply concerned about NSF. They fired more people than they needed and now leadership is illegally reclassifying employees as probationary. www.reuters.com/world/us/us-...

submitted 3 days ago • 1 comment

399 for stat is a lot, right? I wonder if they'd offer a slimmed down sub (no biotech, just Federal science reporting) for those spending their Friday nights waiting for the next gut punch. @statnews.com

submitted 4 days ago • 1 comment

I'm rereading my book Serving The Reich with increasing dismay, even horror. This, for example. Broaden "European" to "Western" and I have to say that I am no longer as confident in this statement as I was in 2013. That frightens me.

submitted 5 days ago • 33 comments

"But Vought appears to be shutting that door firmly behind him, helping to mount a dizzying range of attacks on lifesaving medical research at (and beyond) NIH. Funding cuts to NIH... means that research into rare diseases, already inadequate, may slow down." www.motherjones.com/politics/202...

submitted 5 days ago • 0 comments

"Neither AF-cluster nor CF-random predicts fold switching reliably, especially in more difficult cases." Readable to the lay audience highlighting a bit of a problem/controversy. (Fold switching is just a techy conformational change.)

submitted 6 days ago • 0 comments

The tools that will be used to dismantle the intramural NIH program (and beyond) are quite boring sounding, and attention is already drifting away. Lean into the boring. Things are falling apart.

submitted 8 days ago • 0 comments

Hey, Stargate SG-1 fans: Gateworld just dropped a pretty fun documentary on the history of the show on YouTube. I watched it last night and quite enjoyed it. www.youtube.com/watch?v=8rjo... #kree #indeed

submitted 9 days ago • 11 comments

Scientists, have a position on Schedule F. Make yourself aware, and have the imagination to envision the next four years where all federal researchers/scientists are political appointees.

submitted 10 days ago • 1 comment

If you're wondering if those NHEJ inhibitors are for you, seems like they're doing a great job here...

submitted 10 days ago • 0 comments

Move to rescind, all due respect. As we look to removal of IC directors, this is existential. Grants as we knew them are likely over. There will likely be unmentionable words in science in about a month or two. I think Kipnis and Ring would even agree at this point.

submitted 11 days ago • 0 comments

Please help Sri Kosuri if you can. @uzleuven.bsky.social

submitted 17 days ago • 0 comments

1/ Super excited to see this work from Dr. Kei Haniuda in my lab come together - check it out! Kei was curious about how rotavirus-specific IgA responses are generated in the gut. He found that anti-RV specific plasma cells appear in the MLN and Peyer's Patches very quickly - faster than IgGs

submitted 24 days ago • 2 comments

Truer words couldn't have been said about that first group meeting slide before diving in to the latest and greatest. But yes, also Severance.

submitted 39 days ago • 0 comments

www.czbiohub.org/program-ssfc...

submitted 47 days ago • 1 comment

Always spend the time and money and energy to mount things on the wall. (Buy the good frames that didn't make sense when you were a student. 3M command strips now hold up to 20 lbs. Just do it and don't look back.)

submitted 54 days ago • 0 comments

Was writing my goals for 2025... fifth on the list is "I would like to be faster with compliance." And you may ask yourself, "Where is that large automobile?"

submitted 54 days ago • 0 comments

The Vermont Catamounts score a golden goal in OT to win their first NCAA Men's College Cup Championship over Marshall in the most unreal sequence

submitted 71 days ago • 13 comments

Can AI improve the current state of molecular simulation? www.owlposting.com/p/can-ai-imp... in my first podcast, I spend 2 hours interviewing Corin Wagen and Ari Wagen, two brothers who are building the next generation of molecular simulation for drug discovery and material science

submitted 84 days ago • 1 comment

That we had a Noah Kahan lookalike contest at UVM makes me so happy. Clear heterogeneity in degree of effort applied.

submitted 82 days ago • 0 comments

!!Just learned that faculty from Harvard, Stanford, Princeton, and others won't be eligible in the upcoming HHMI Investigator competition (2026?). It will be dedicated to bringing in people from institutions not currently well-represented at HHMI - max 1 current Investigator.

submitted 83 days ago • 4 comments

Our paper about the development of programmable antigen-gated G-protein-coupled engineered receptors (PAGERs) is published today! www.nature.com/articles/s41... PAGERs couple detection of a wide range of custom-defined antigen to a variety of output including transgene expression and cell signaling.

submitted 83 days ago • 1 comment

Now we know how these AI accounts summarize so many Bio ML papers every day

submitted 86 days ago • 2 comments

This is just wonderful, a fine detective story and written so humanely. Time well spent.

submitted 86 days ago • 0 comments

The thing is, we are subject to the same economic forces + value system as our wider society. The myth of meritocracy for academic success only holds if being "deserving" means alignment w/power. The choice b/w the "best" science and the ideals of equity is a false one. We have to do better.

submitted 89 days ago • 2 comments

OK- here we go. Sorry for the delay, I was not prepared for the exertion required in the thrill-a-minute adventure that is… CACAO FERMENTATION. Yes, this will actually take 5 days. After that two days of drying. I’m not making this up. Nothing happens. Really. You’ll see. Anyway, off we go!

submitted 108 days ago • 129 comments