dkarthikey1.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

We @prescientdesign.bsky.social Genentech pre-printed our "Lab-in-the-loop for therapeutic antibody design." We built a general ML system to accelerate molecule design for challenging, therapeutically relevant targets. www.biorxiv.org/content/10.1...

submitted 5 days ago • 1 comment

You in the Triangle area and thinking about standing up for science? Come to my beloved 2nd workplace and make a sign 😊🍻 supplies provided! You can leave a sign w me and i can bring it up to DC! @standupforscience.bsky.social

submitted 7 days ago • 3 comments

Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update: jamieheather.github.io/stitchr/

submitted 7 days ago • 2 comments

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

submitted 28 days ago • 1327 comments

Musks method of ruthlessly enforcing efficiency by removing things and adding them back if the system breaks has worked well for pruning complexity of products, pipelines and entire companies. But applying this methodology to govt is dangerous and will result in greater harm to the American people

submitted 31 days ago • 1 comment

Good combo! A nasal vaccine with self-amplifying RNA (much less dose required for v potent immune response), complete protection effective vs both H5N1 and H7N9 viruses in experimental models www.biorxiv.org/content/10.1...

submitted 50 days ago • 19 comments

On the merits of reading papers, attending conferences, preprinting manuscripts… Overseen at the Library of Congress.

submitted 64 days ago • 0 comments

Today OpenAI announced o3, its next-gen reasoning model. We've worked with OpenAI to test it on ARC-AGI, and we believe it represents a significant breakthrough in getting AI to adapt to novel tasks.

submitted 73 days ago • 20 comments

Unsure if people on bsky are aware of o3s existence. But if anyone wants to talk I’ve been itching all day

submitted 73 days ago • 0 comments

How to learn generalizable rules across complex sequence-function maps? 💡In our new preprint we propose a framework for learning two-point statistics and use it to discover biophysical rules of TCR co-specificity that generalize to unseen ligands ! ✨ arxiv.org/abs/2412.13722

submitted 75 days ago • 0 comments

Given the subtext here I wouldn’t be surprised if both X and Bsky develop extremely close but distinct niches: the former to blast information and reach broader audiences, and the latter as a place of discourse with members of a particular community.

submitted 89 days ago • 0 comments

🧙🪄Summoning Alex to 💙🦋 so the Bio x ML community can celebrate ESM-C with him on here as well

submitted 89 days ago • 0 comments

CA Coworking 🌉🌅

submitted 97 days ago • 0 comments

Calling all T-cell aficionado's. Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi. I'll also be there! www.uantwerpen.be/en/conferenc... #ImmunoSky

submitted 103 days ago • 1 comment

#GoodThingsComeToThoseWait Sorry it's taking us a while. Promise that the wait will be well worth it! #OpenFold3 Love all the great work that's already been done #HelixFold3 #Ligo #Chai1 #Protenix #Boltz1

submitted 104 days ago • 3 comments

Surely I misheard. There’s no way Dr. Oz, the OG grifter, president of grift university, has been tapped to lead the largest and most influential US healthcare entity.

submitted 104 days ago • 181 comments

My first Skeetorial! 💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem. TLDR: We pretrained LLMs on ~8M TCR & pMHC seqs Finetuned on sparse pMHC->TCR pair data Validated CDR3b sequences to unseen antigens >> random performance on IMMREP2023 "private" antigens

submitted 104 days ago • 1 comment

TCR-TRANSLATE: Conditional Generation of Real Antigen Specific T-cell Receptor Sequences https://www.biorxiv.org/content/10.1101/2024.11.11.623124v1

submitted 111 days ago • 1 comment

LLMs are fantastic learners of arbitrary sequence to sequence mappings. Text summarization, Q&A, and machine translation, etc. So what happens if you apply them to the many-to-many mapping of the TCR cross reactivity landscape? Turns out, some pretty cool things. Check it out 😏

submitted 111 days ago • 0 comments

The fate of this app hangs in the balance tonight…

submitted 118 days ago • 0 comments

Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC https://www.biorxiv.org/content/10.1101/2024.10.16.618634v1

submitted 137 days ago • 0 comments

Someone should do an autopsy on Twitter. When did it stop being Twitter? I know it’s easy to point at Elon but what really happened? Beyond the obvious what second order phenomena can be traced to its decline? 3rd/4th?

submitted 137 days ago • 0 comments

Insane finding: repeat covid infections result in milder symptoms but a greater propensity for long-COVID. Something really interesting is going on here and I want to know if it’s T or B cell mediated

submitted 137 days ago • 1 comment

What other keywords should I add to the MLSky feed? It's a tricky balance -- something too technical never triggers but eg #llm #chatgpt even "PyTorch" &c get mostly spam

submitted 137 days ago • 4 comments

It appears that my peoples (scientists) are preparing for a mass migration back onto here come election szn so whattup fam, I’m back

submitted 137 days ago • 0 comments

Back on here because I’m noticing a dangerous trend on Twitter where among other things bot engagement is being used to silence organic activity, particularly on controversial matters. Gonna try to use my codes to bring people on here as voting szn draws near.

submitted 406 days ago • 0 comments

Totally legit question for all the PIs on here: when working on a problem that has a lot of other people publishing on it, how does one write an introduction that doesn’t sound like a paraphrasing of 20 other papers 😩

submitted 511 days ago • 0 comments

The UNC Genetics Dept / BCB / GMB retreat was this week in Asheville NC and it was stellar. These two students from @alexr.bsky.social lab gave a hilarious and emotional rollercoaster of a presentation about getting scooped and still pulling through. Poster sessions and talks were all 👌

submitted 527 days ago • 3 comments