dougkojetin.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Now published! Read our newest story! doi.org/10.1038/s414...

submitted 3 days ago • 0 comments

ATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...

submitted 5 days ago • 83 comments

I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!

submitted 17 days ago • 707 comments

😳🤯. Dr. Laurer was the coauthor of the memo yesterday acknowledging that the NIH funding freeze was illegal and directing staff to resume issuing grants.

submitted 18 days ago • 2 comments

We need one of these for our lab

submitted 21 days ago • 0 comments

This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl! www.biorxiv.org/content/10.1...

submitted 21 days ago • 1 comment

Application deadline extended to Feb 14, 2025! Do you know any undergraduate students interested in structural biology? Check out this summer program at Meharry Medical College in Nashville TN!

submitted 21 days ago • 0 comments

Trainees who applied for an NIH diversity fellowship whose applications were withdrawn/not being reviewed, there's a NYTimes reporter who wants to talk, especially interested in applicants with disabilities. DM me & I'll put you in touch, will keep all contact confidential. Please amplify

submitted 22 days ago • 8 comments

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...

submitted 23 days ago • 6 comments

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

submitted 23 days ago • 86 comments

Hey all, I know it’s a sewer, but the main action and fight on the NIH is over on Twitter. We could use your voice. I’ve already been contacted by reporters based on posts over there, it’s your best chance to be heard.

submitted 23 days ago • 14 comments

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

submitted 24 days ago • 82 comments

White House budget proposal may slash NSF funding from 9 billion to 3 billion a year.

submitted 25 days ago • 29 comments

Not #nuclearreceptors

submitted 25 days ago • 0 comments

Welcome to BlueSky, new/old #nmrchat followers! 😊🧲 ▶️ Don’t miss out - check out not one, but five (!) magnetic resonance starter packs! Discover familiar names to follow. ✅ To follow everyone on the list, just tap the upper right corner! 🤓 or tick each 🤠 bsky.app/profile/nmr9... #NMRchat #NMR

submitted 26 days ago • 0 comments

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

submitted 26 days ago • 5 comments

Just sitting in my office, saying "that seems bad" out loud to myself every hour or so.

submitted 26 days ago • 6 comments

Extremely disappointed to see HHMI decide to kill their Inclusive Excellence program, including terminating the current IE3 awards to over a hundred institutions effective this year in the middle of a 6-year grant. I was hoping HHMI (and other private funders) would continue to lead the way.

submitted 26 days ago • 18 comments

Here’s why we need to study & fund developmental biology: to understand, prevent & treat birth defects. Infants can’t speak, so we must be their advocates

submitted 27 days ago • 0 comments

Our latest work on tackling streptogramin resistance in collaboration with the Seiple lab is now up as a preprint. We (led by Pooja Asthana) targeted a resistance enzyme, VatD, with fragment-based drug discovery! www.biorxiv.org/content/10.1...

submitted 28 days ago • 1 comment

The latest from @science.org on the situation at NIH. @meredithwadman.bsky.social and Jocelyn Kaiser getting all the info they can. www.science.org/content/arti...

submitted 31 days ago • 3 comments

So awesome that Mitch Lazar is visiting Vanderbilt as part of our Apex Lecture Series (scientists who are influencing the trajectory of their fields) to talk about REV-ERB #nuclearreceptors !

submitted 31 days ago • 0 comments

I’m putting together a post on what’s going on in the trenches in various parts of the NIH. Anyone who would like to share experiences (anonymously!) can reach me at Dblowe.18 on Signal

submitted 31 days ago • 4 comments

Another shoe drop. Early termination of FOA.

submitted 38 days ago • 1 comment

In The Pipeline blog featuring estrogen receptor papers with contributions from @nrimpact.bsky.social members @docfanning.bsky.social and @nelsonlab.bsky.social #nuclearreceptors

submitted 38 days ago • 0 comments

More from inside NIH: Per a source with knowledge, for all internal research (of which there is like $10 billion worth or so), ALL purchasing shut down as of yesterday. That means gloves, reagents, anything involved with lab work, which means a lot of that work will stop.

submitted 38 days ago • 92 comments

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

submitted 40 days ago • 8 comments

Latest report from a highly credible source. An SRO issuing study section guidance to not address the Diversity Plan or include it in the impact score for a mechanism that required the plan to be included.

submitted 40 days ago • 6 comments

Anyone else hearing that NIH IC’s Advisory Council meetings are being cancelled?

submitted 40 days ago • 7 comments

Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...

submitted 40 days ago • 0 comments

Are you interested in understanding how the wiggles & jiggles of proteins impact the thermodynamics of ligand binding or catalysis? Well, you are in luck! We are searching for a postdoc to explore these concepts. More details: www.vanderbilt.edu/postdoc/pros... or email [email protected]

submitted 41 days ago • 1 comment

In-depth article on chronic pain, with my friend @robgereau.bsky.social and Allan Basbaum heavily interviewed as scientists studying pain: ‘We die in pain, we don’t die of pain.’ www.nytimes.com/2025/01/12/m...

submitted 50 days ago • 0 comments

Thread - definitely something to watch:

submitted 55 days ago • 5 comments

Congrats to Anna Eitel, the Department of Biochemistry's January Trainee of the Month! 👏🏾👏👏🏻👏🏽' Her advice to other students is to persevere! "Everyone has bad days (or even months), but you will only succeed if you don’t give up."

submitted 55 days ago • 0 comments

Nature Communications (open) UnidecNMR: automatic peak detection for NMR spectra in 1-4 dimensions, Charles Buchanan, Gogulan Karunanithy, Olga Tkachenko, Michael Barber, Michael T. Marty, Timothy J. Nott, Christina Redfield & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲

submitted 55 days ago • 0 comments

Substances in human birth tissues, like the umbilical cord and the amniotic membrane, could be used for pain relief for people who have had surgery.

submitted 63 days ago • 0 comments

Many thanks to @dereklowe.bsky.social for highlighting our recent study in @elife.bsky.social on synthetic ligand cobinding to the #nuclearreceptor PPARγ! I'm a long-time reader of the Blog, so this is quite a treat to be featured (in a positive light)! www.science.org/content/blog...

submitted 80 days ago • 1 comment

I led the journal club course for the first-year quantitative graduate students this semester. We spent the semester dissecting papers and discussing how to give constructive feedback. Their final project was to review a preprint, and they crushed it! wankowiczlab.com/reviews/

submitted 80 days ago • 1 comment

I created this Starter Pack for PhDs and Postdocs in Structural Biology to help connect with colleagues who share similar interests and concerns in the field. Feel free to recommend people or yourself! I'll be adding people 💪🏼😁 bsky.app/starter-pack...

submitted 107 days ago • 28 comments

Wow, thanks for the highlight @sbgrid.bsky.social and KeAndreya! #nuclearreceptors

submitted 83 days ago • 0 comments

Very excited to present my seminar "Manipulating Estrogen Receptor to Engage New Therapeutic Mechanisms of Action in Breast Cancer Cells" at the Vanderbilt-Ingram Cancer Center. I'm looking forward to learning a lot from the folks here. Huge thanks to @dougkojetin.bsky.social for the invite!

submitted 88 days ago • 0 comments

Great community assessment here. Still unable to find alternate conformations. Protein dynamics the next big obstacle clearly 👀

submitted 91 days ago • 3 comments

Fantastic to be able to prevent a life-threatening cancer with a simple vaccine.

submitted 92 days ago • 0 comments

A Bluetorial on the history the Johns Hopkins Postdoctoral Association from an unusual vantage point 1/n

submitted 97 days ago • 2 comments

⚠️ Tag with Caution ⚠️ New preprint led by Kerstin Dörner in Maria Hondele’s lab with contributions from Fan Cao on our side on the effects of tagging with FPs and peptides on condensation and phase separation 🧪 TL/DR: It’s complicated See more: doi.org/10.1101/2024...

submitted 148 days ago • 1 comment

Do you need a starting pack of researcher working on intrinsically disordered proteins? Well, you might head over to @idpseminars.bsky.social and hit followers. Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.

submitted 98 days ago • 0 comments