doylemt1.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota https://www.biorxiv.org/content/10.1101/2025.02.17.638638v1

submitted 6 days ago • 0 comments

We are pleased to share our latest work uncovering that the disruptions of the linkages between bacterial outer membrane and peptidoglycan enhances the resistance to bile salts! www.biorxiv.org/content/10.1...

submitted 12 days ago • 1 comment

had an extremely fun few days @lorneproteins.bsky.social filled with incredible talks, scientific discussion and a non zero amount of silliness

submitted 11 days ago • 0 comments

So proud of my student, Lucas Shen! He's presenting his dissertation seminar today! So fun when the students succeed. Join me in congratulating him!

submitted 13 days ago • 1 comment

Beautiful talk by ShuSin Chng @figlegend.bsky.social in the afternoon Asia Pacific Protein Association session @Lorneproteins.bsky.social … bacterial lipid transport clarified!

submitted 13 days ago • 1 comment

I walked this hall when I worked there. This is so sad and maddening. What is the benefit of this?

submitted 14 days ago • 0 comments

You will ultimately gain vastly more satisfaction from the relationships you form & the ways in which you uplift other people than you will from your "achievements".

submitted 25 days ago • 2 comments

All NIH/NSF awards may be paused as of today. Money is disbursed annually, so if you have your money, you're OK for a while. My next R35 grant year starts Apr 1. I hope Trump doesn't read my X/bsky feeds that say he's a racist, a rapist, a cheat, & a traitor. www.washingtonpost.com/business/202...

submitted 27 days ago • 1 comment

Gentle reminder that if you truly value diversity in the workforce, top down executive orders may/will change implementation but it shouldn’t change your dedication to building the best possible team/group/cohort/generation of researchers

submitted 32 days ago • 5 comments

As someone who formed their career over 6 years working at the NIH at NIDDK, friends treated at the NIH Clinical Centre, Fellowship and Grant funding my research on bacterial physiology and antibiotics, I feel dismayed by what is happening to a great institution and nervous as to what is to come.

submitted 32 days ago • 0 comments

Happy to start a new social life on BlueSky ! Love from Marseille !

submitted 37 days ago • 2 comments

Anybody still looking for their friends on this site? 🧪 If membranes or the molecules therein are your thing, please check out these TWO starter packs on membrane proteins, lipids and transport processes! With many new arrivals since the last post! go.bsky.app/AEeXh86 go.bsky.app/PnXecJZ

submitted 40 days ago • 4 comments

A novel broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance https://www.biorxiv.org/content/10.1101/2025.01.11.632532v1

submitted 43 days ago • 0 comments

A little scientist in the making. 🔬👩‍🔬

submitted 44 days ago • 0 comments

Our MultiFOLD2 server is also now freely available to all. It's the top-ranked server on the hardest domain targets in #CASP16 by GDT_TS. With integrated stoichiometry prediction it outperforms AF3 on common multimer subsets in CAMEO. www.reading.ac.uk/bioinf/Multi...

submitted 74 days ago • 1 comment

Unicore enables scalable and accurate phylogenetic reconstruction with structural core genes https://www.biorxiv.org/content/10.1101/2024.12.22.629535v1 🧬🖥️🧪 https://github.com/steineggerlab/unicore

submitted 62 days ago • 2 comments

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

submitted 63 days ago • 24 comments

What is wild to think about is when my grandparents were children (born in 1919, 1921, 1929, and 1930) there were NO antibiotics. Even when my parents were born (1954 and 1955) there were limited numbers of antibiotics.

submitted 75 days ago • 1 comment

Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.

submitted 79 days ago • 2 comments

First last author paper FINALLY out today. Thank you to all the authors for their hard work ☺️

submitted 79 days ago • 4 comments

Oh, Alphafold predicted me a beta helix... I didn't even know they existed! Does anyone know of examples of such structures, and what they are good for? Cross your eyes for a stereo view!

submitted 81 days ago • 2 comments

In a multidisciplinary study led by Georgina Benn and Tom Silhavy we show the role of OmpA in controlling the organisation of the outer membrane and in sharing the mechanical load. www.pnas.org/doi/10.1073/....

submitted 82 days ago • 3 comments

"...Australia incentivises fast research rather than slower but potentially more impactful research. EMCRs highlighted that current metrics encourage and focus on rapid results and outputs instead of longer-term or interdisciplinary work or outputs that may require a greater amount of time."

submitted 83 days ago • 1 comment

Really excited to be sharing our newest work on the bacterial Tol-Pal complex! The amazing Jiang YEOW solved cryo-EM structures of the TolQRA complex in 2 rotary states, aiding us to come up with a model for force transduction across the cell envelope! Pls RT! #SGBUG #SCELSE_SG #ChemNUS

submitted 86 days ago • 2 comments

There is much talk about how #peerreview is broken and needs some type of peristroika. However, I just reviewed a manuscript where in the initial review I pointed out what I saw as a bit of flaw. The authors took this very seriously and they resubmission was absolutely fantastic..... 1/2

submitted 88 days ago • 1 comment

Anyone have a good paper looking at presence/absence rates of outer membrane porins in E. coli clinically? What is the occurrence rates of infections caused by E. coli lacking ompA/C/F? I've lots of papers showing the impact of omp loss on AMR and virulence, but how common is this? #MicroSky

submitted 88 days ago • 8 comments

My first ever Bluesky post is a new #preprint alert! What if we could put anything into a protein cage? Our new in vitro encapsulin assembly system is esay to use and enables the pacakging of protein and synthetic cargo! www.biorxiv.org/content/10.1...

submitted 90 days ago • 1 comment