Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself! - ThreadSky

scientificdiscovery.dev • 132 days ago

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly.

Just how many types of antibiotics were discovered during that time?

So, I visualized it myself!

Comments

kelliepharmd.bsky.social•130 days ago

📌

ulriche.bsky.social•131 days ago

Have I missed Penicillin on your chart?

scientificdiscovery.dev•131 days ago

It's fourth from the top!

ulriche.bsky.social•131 days ago

Ah ... thanks. I expected it as the first one, therefore I missed it.

shooshan.bsky.social•131 days ago

📌

rporetsky.bsky.social•103 days ago

📌

andyrootmd.bsky.social•129 days ago

📌

danielsaraga.bsky.social•131 days ago

Cool, nice chart! I have made a similar one showing also commercialization and resistance.
Interestingly, resistance was sometimes observed before market introduction.

https://bsky.app/profile/danielsaraga.bsky.social/post/3lbjmk35wys2e

roby-b.bsky.social•131 days ago

I suspect this ("resistance observed before market introduction") is more common than we realize, mainly bc we don't test for resistance to a drug until it, well, exists / is used. The "antibiotic resistance is ancient" lit is pretty persuasive that resistance to most (all?) abx predates us humans.

echalstrey.bsky.social•132 days ago

🤞a bunch of new ones in the pipeline as promised by all those AI-for-drug-discovery startups 😅

daanspeth.bsky.social•130 days ago

📌

p373r0.bsky.social•131 days ago

Thank you so much. I don’t want to sound demanding, but the thought that popped into my head was “ and one of antibiotic resistance please “ 🫣😊

nonviolence.bsky.social•132 days ago

Antibiotic resistance in food animals nearly tripled since 2000
https://www.sciencedaily.com/releases/2019/10/191009132321.htm

nonviolence.bsky.social•132 days ago

Result
https://www.bdi.ox.ac.uk/news/new-study-estimates-that-antibiotic-resistant-bacterial-infections-already-cause-more-deaths-than-hiv-aids-or-malaria

nonviolence.bsky.social•132 days ago

7 out of 9 Americans take antibiotics annually. Soon the world will follow and we will enter an era of antibiotic resistance. https://www.who.int/news/item/26-04-2024-who-reports-widespread-overuse-of-antibiotics-in-patients--hospitalized-with-covid-19

nonviolence.bsky.social•132 days ago

If antibiotics stop working and we face more new pandemics...
https://pmc.ncbi.nlm.nih.gov/articles/PMC2599911/

nonviolence.bsky.social•132 days ago

Same root issues
https://www.theguardian.com/world/2020/jul/06/coronavirus-world-treating-symptoms-not-cause-pandemics-un-report
The role of meat appetite in willfully disregarding factory farming as a pandemic catalyst risk
https://www.sciencedirect.com/science/article/pii/S0195666321001860

nonviolence.bsky.social•132 days ago

Oldie but goody. The challenge is about "habits". Ergo, little reason to be optimistic?
https://www.youtube.com/watch?v=o3oDpCb7VqI

scientificdiscovery.dev•132 days ago

We have a new page about this here:

cispt2.bsky.social•131 days ago

This is a fantastic visual display.

We tried a few years back to build chemical classes and approval year into a display (https://pmc.ncbi.nlm.nih.gov/articles/PMC5882019/) . What you've created is wonderful.

scientificdiscovery.dev•131 days ago

Thank you very much! That makes me happy ☺️ And that's a great paper!

scientificdiscovery.dev•131 days ago

Out of curiosity, I just tried out another version based on the dataset in your article.

Here, the additional dots in each row show later antibiotics within each class.

I didn't realise how many cephalosporins and sulfonamides there were! Super interesting.
https://github.com/saloni-nd/misc/tree/main/antibiotics-timeline%2Fantibiotics-us-approvals

noddin0ff.bsky.social•132 days ago

Tnx!

peiferlabunc.bsky.social•132 days ago

This will be great for some of my classes--thanks!

brooklynkid53bskys.bsky.social•132 days ago

??
many of these drugs would not be approved if introduced today
eg

scientificdiscovery.dev•132 days ago

The timeline is about a historical perspective of when each antibiotic drug class was first used, and doesn't show which ones are still in use. (Although most classes are.)

brooklynkid53bskys.bsky.social•132 days ago

sorry, the point is if we did a silly thing and applied todays stds for safety and efficacy , many of those drugs in the golden age would not have been approved, eg the large number of approvals is cause standards for safety were lower

scientificdiscovery.dev•132 days ago

Oh awesome! Glad to hear it :)

rravinetto.bsky.social•129 days ago

This also seems to overlap with pre #TRIPS age, when R&D was generally not delayed by #intellectualproperty -related monopolies? @elstorreele.bsky.social @ingelbeen.bsky.social @ellenthoen.bsky.social

malia0212.bsky.social•130 days ago

Life saving antibiotics 😷😷

steventong.bsky.social•130 days ago

📌

christy21.bsky.social•132 days ago

Well done. 👏 Hard work!

erinacean.bsky.social•132 days ago

Sulphonamide was a game-changer for maternal mortality due to puerperal infection.

erinacean.bsky.social•132 days ago

It was also effective (at first) for gonorrhoea, replacing invasive and prolonged treatment. There was a short phase, post-pencillin, when it was believed that sexually-transmitted infections were 'these dying diseases'. The rise of resistant strains, among other things, proved this wrong.

scientificdiscovery.dev•132 days ago

Really interesting! I wrote about some of that history here:

erinacean.bsky.social•132 days ago

That's a useful resource.
Several STIs were more or less discovered when they were treated as believed to be gonorrhoea but did not respond to antibiotics. E.g. chlamydia.

ianfichten.bsky.social•129 days ago

A timeline of rocket propellant developments has pretty much the same pattern

thewonderingmind.bsky.social•131 days ago

📌

scientificdiscovery.dev•132 days ago

The data comes from this very interesting paper on antibiotic development: https://doi.org/10.1016/j.mib.2019.10.008

And is part of a new article I wrote on the Golden Age of Antibiotics and how we can spark a new one!

maxtide.bsky.social•132 days ago

Neat. How is the concern about resistance going? Are any l of these coming off the list?

scientificdiscovery.dev•132 days ago

You're in luck! I wrote another article introducing how that works:

maxtide.bsky.social•132 days ago

What luck, thx!

oldhippie420.bsky.social•130 days ago

Since I have severe allergies to a whole lot of medicine, there are only 2 antibiotics I can take. It is vital that I stay as healthy as possible. I cannot afford to have one of the antibiotics become resistant to my body.

maxtide.bsky.social•130 days ago

Best wishes to you. I'm sorry for that challenge you face :l.

stephy.bsky.social•131 days ago

📌

scientificdiscovery.dev•131 days ago

You can find the data and scripts to recreate this timeline on GitHub:

scientificdiscovery.dev•131 days ago

Here's another chart as well.
Both are in the same article.

colleenfellows.bsky.social•132 days ago

Great graphic. The development of antibiotics changed the world. I was told many times about my grandparents devastation as my uncle died at 13 of spinal meningitis, just as penicillin became available. It wasn't available in southern Montana yet. They tried to have it delivered, but too late.

scientificdiscovery.dev•132 days ago

Thank you! Oh that's really sad to hear. It's a big interest of my work to try to find ways to speed up medical innovation & improve its quality, and real life stories of how it affects people are gut-wrenching. It's hard to imagine now living without treatments like it!

doctorjohn63.bsky.social•131 days ago

Thanks

jc-ok.bsky.social•132 days ago

📌

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