drellisdon.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Great to see this study published. Congrats to Roger Daly and team! www.nature.com/articles/s41...

submitted 4 days ago • 0 comments

#Autophagy and #mTOR papers from last week, there’s always something to every taste, enjoy thanks to @Bims_BiomedNews pre-selection. biomed.news/bims-auttor/...

submitted 5 days ago • 0 comments

All-atom fixed backbone protein sequence design with FAMPNN @richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.1...

submitted 6 days ago • 0 comments

Our paper is out! LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

submitted 6 days ago • 4 comments

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share! structures| nanobodies |human immune responses | mRNA-LNP www.biorxiv.org/content/10.1...

submitted 11 days ago • 0 comments

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

submitted 27 days ago • 503 comments

Must read for California www.nytimes.com/2025/01/25/o...

submitted 33 days ago • 35 comments

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

submitted 34 days ago • 1 comment

It was perfectly clear last night until about 11pm which allowed me to finally have a good look at the Horsehead Nebula. Here is the result of 61 minutes of data (366 stacked images) from the Seestar S50. Slight enhancement in Lightroom.

submitted 34 days ago • 9 comments

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

submitted 36 days ago • 0 comments

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub–200-keV direct electron detector!

submitted 53 days ago • 0 comments

Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "I am a book I neither wrote nor read."-Delmore Schwartz

submitted 54 days ago • 1 comment

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

submitted 83 days ago • 1 comment

The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪 www.rcsb.org/structure/9CE3

submitted 86 days ago • 0 comments

Did someone mix up AM and PM over at the #NHMRC? I'm all for releasing grant outcomes as soon as possible, but 1:30 AM is a rather unconventional choice!

submitted 94 days ago • 2 comments

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1

submitted 97 days ago • 0 comments

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

submitted 98 days ago • 6 comments

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project. www.science.org/doi/10.1126/...

submitted 99 days ago • 0 comments

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances. Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council. www.science.org/doi/10.1126/...

submitted 99 days ago • 5 comments

Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪 www.science.org/doi/10.1126/...

submitted 99 days ago • 1 comment

We had a great time yesterday at the Children's Tumour Foundation Australia Conquer #NF in Colour event in Melbourne. It was great to join so many others in supporting the important work of #CTFAustralia, who advocate for and support the 1:3000 people who are diagnosed NF.

submitted 102 days ago • 1 comment

The community is growing: Metabolism Starter pack V2.0 go.bsky.app/VavECSX

submitted 104 days ago • 8 comments

The Baker lab seems serious about moving into enzyme design. Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory. www.biorxiv.org/content/10.1...

submitted 104 days ago • 6 comments

franxfiction.com/3264-2/

submitted 104 days ago • 0 comments

Very exciting! Thanks to Cell Press, Arun Shukla, and the team for the Preview article on our recent advances in uncovering the structure of LYCHOS/GPR155! www.cell.com/cell/abstrac...

submitted 105 days ago • 0 comments

🧪 In my Editors' Choice piece in Science Signaling this week, I highlight a structural study by Bayly-Jones et al. in Nature, showing that the lysosomal cholesterol-sensing protein LYCHOS is a bit of a hybrid, containing a GPCR domain and a plant-like transport protein domain. Read my summary here:

submitted 107 days ago • 0 comments

Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x Paper: tinyurl.com/c7szhtfa

submitted 107 days ago • 1 comment

Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵‍💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social rdcu.be/dZSPQ

submitted 108 days ago • 6 comments

On November 12th, we'll hear from Pavel Afonine of Berkeley Lab with an introduction to AQuaRef: Machine Learning Accelerated Quantum Refinement of Protein Structures. AQuaRef Tuesday, November 12, 2024 at 12:00pm EDT Pavel Afonine Register here: https://buff.ly/3AelDrK #structuralbiology #SBGrid

submitted 108 days ago • 0 comments

Pre-print 🚨 alert! We used AI protein structure prediction to analyze ~10,000 Borg proteins, revealing potential capsid proteins & viral-like features in these massive elements from methane-eating archaea. Could they be the first archaeal giant viruses? Check it out!

submitted 109 days ago • 1 comment

😮 Exciting study from G. Zanetti's lab exploring COPII assembly on reconstituted membrane carriers and microsomes by #CryoET: rdcu.be/dZK8M ❄️🔬

submitted 109 days ago • 0 comments

Does anyone have an up to date list of protein-protein interaction (PPI) databases? For example, Human PPI- Computing the Human Interactome, FlyPredictome etc? #AlphaFold #protein #cryoEM

submitted 110 days ago • 3 comments

Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC

submitted 111 days ago • 72 comments

Check out our new preprint on plant🌱mitoribosome! We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit. 📖: www.biorxiv.org/content/10.1... #CryoEM

submitted 120 days ago • 1 comment

I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is officially out! #CryoEM doi.org/10.1038/s414...

submitted 176 days ago • 0 comments

Europa Clipper Launches! https://buff.ly/3Yr12to The Jupiter-bound mission seeks to discover if the icy moon contains the ingredients necessary to support life. 🧪 🔭 👩‍🔬

submitted 132 days ago • 1 comment

That was a sure thing #chemnobel

submitted 141 days ago • 0 comments

Excited to see our latest study published! We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain #cryoEM #mTOR #GPCR #auxin www.nature.com/articles/s41...

submitted 141 days ago • 1 comment

📜 LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR 🧑‍🔬 Charles Bayly-Jones, Christopher J. Lupton, Michelle L. Halls, Andrew M. Ellisdon, et al. 📔 @natureportfolio.bsky.social 🔗 www.nature.com/articles/s41... #️⃣ #PlantScience #Auxin #Phytohormones

submitted 147 days ago • 0 comments