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duckswabber.bsky.social
Avian influenza & avian virome ecology | "Expert in Ducks" | (she/her) | michellewille.com
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β€œFunding by the CDC for two monthly peer-reviewed journals, Emerging Infectious Diseases and Preventing Chronic Disease, will be cut.” EID has published novel, important work that brings #IDSky issues to light. Its loss will hurt.

In China, across markets, birds, humans: 32.6% for avian influenza, where 7% H5. LBMs and slaughterhouses highest prev. No avian influenza in human surveillance. πŸ‘‰ www.researchsquare.com/article/rs-6...

Mathematical modelling of ref panel of HPAI in primary chicken embryo + duck embryo fibroblasts: evaluation of virological parameters + epi parameters. in duck cells longer cell death + generation time πŸ‘‰ www.biorxiv.org/content/10.1...

A prime-boost vaccination trial using 5 commercial vaccines, including H5 subunit, vector, RNA, whole inactivated in fattening geese. Some vaccines req 1 vs 2 doses, but all geese that seroconverted were protected from challenge (but still some shedding) πŸ‘‰ www.mdpi.com/2076-393X/13...

Reduced infections of HPAI in humans and poultry in Egypt, suggesting effectiveness of "Supported Intervention Package". Egypt accounts for ~40% of human cases πŸ‘‰ www.researchsquare.com/article/rs-5...

Self-renewing organoid cultures allow for long-term culture and can approximate the in vivo cellular diversity and organization of tissues. Innoc w LPAI/HPAI = appropriate receptors. Useful approach! πŸ‘‰ virologyj.biomedcentral.com/articles/10....

eBird and Bird Flu Radar, in combination with global cattle density data used to evaluate risk of HPAI jumping from wild birds to cattle in Denmark w heterogeneous temporal and spatial distribution of HPAIV spillover risk πŸ‘‰ arxiv.org/pdf/2504.12432

When should you report mortality in farmed birds? An eightfold increase of the mortality for two consecutive days compared to the average mortality the previous week in mule ducks πŸ‘‰ veterinaryresearch.biomedcentral.com/articles/10....

H4N1 binds to human receptors + exhibits affinity for human lung + tracheal tissues, replicates efficiently in human cell lines, induce pneumonia in mice. Zoonotic potential of many subtypes. πŸ‘‰ virologyj.biomedcentral.com/articles/10....

High resolution data from an affected farm in Michigan: daily bulk tank information, herd management + feed intake data, temperature alerts generated from cows' intraruminal automated sensor devices during the year of the outbreak and the previous year πŸ‘‰ www.sciencedirect.com/science/arti...

Use of ecological niche models to reveal whether surveillance in Khazakstan is sensitive enough to detect HPAI outbreaks, trained on data form neighbouring countries. πŸ‘‰ www.mdpi.com/1999-4915/17...

Recombinant H5 HA and N1 NA proteins coupled to liposomes confer protection from disease in mice when antigens are presented as an adjuvanted nanoparticle vaccine πŸ‘‰ www.sciencedirect.com/science/arti...

lactating cows infected w B3.13 via the hindquarters of the udder, followed by reinfected at unaffected forequarters = secondary inoculation did not result in clinical manifestations or virus shedding in milk πŸ‘‰ www.nature.com/articles/s41...

Iowa had largest poultry losses in 2022-23. Attempting to address impact of inland water surface area, Canada geese abundance on risk, but difficult w/o farm location data. πŸ‘‰ www.mdpi.com/1660-4601/22...

Latest EFSA report, now out! πŸ‘‰ efsa.onlinelibrary.wiley.com/doi/abs/10.2...

The HPAI safety and immunogenicity vaccine trials in Black Vultures and Condors prior to the roll out. Important measure to save endangered species from HPAI. πŸ‘‰ wwwnc.cdc.gov/eid/article/...

Overview of HPAI panzootic, with species affected and nice analysis of virus movement across the different phases of the panzootic. πŸ‘‰ arxiv.org/pdf/2504.11910

stakeholder landscape and outbreak decision-making and response processes in the UK and USA for HPAI outbreak. smallholders + backyard poultry owners need to be better represented in policy-industry communication pathways, information sharing critical πŸ‘‰ www.frontiersin.org/journals/vet...

For HPAI to transmit between people, the HA must changing binding preference. One 2344e virus could switch receptor binding with a single Q226L mutation, while a 2.3.4.4b might require more complex changes. L133a Ξ” and 227Q are vital for this phenotype πŸ‘‰ www.pnas.org/doi/10.1073/...

Lectin histochemistry of mammary glands of livestock and humans: rich in a2,6 receptors, followed by a2,3. HPAI bound to mammary tissues from cattle and pigs. πŸ‘‰ www.biorxiv.org/content/10.1...

Differences in receptor-binding preferences for dairy cattle HPAI H5N1 viruses between studies are unclear πŸ‘‰response: www.nature.com/articles/s41... No binding to a2,6 πŸ‘‰ www.nature.com/articles/s41... πŸ‘‰ www.nature.com/articles/s41... Binding to a2,6 (original) πŸ‘‰ doi.org/10.1038/s415...

Receptor specificity of CVV A/American Wigeon, and A/catte/Texas using 3 assays = strict specificity for binding to avian-type receptors, as also reported recently by others πŸ‘‰ www.nature.com/articles/s41...

Receptor specificity of A/bovine/Ohio addressed using 4 different assays = no evidence for human receptor specificity, avian-type receptor specificity, which agrees with the inefficient transmission of the virus between ferrets πŸ‘‰ www.nature.com/articles/s41...

Review of avian influenza viruses in pigeons, birds which have direct contact with livestock and poultry. Diversity of subtypes recovered. πŸ‘‰ www.mdpi.com/1999-4915/17...

avian beta defensin 11 at different concentrations caused changes in cytokine expression ex vivo and in vivo erythrocytes from chickens infected with H9N2 - immunomodulator? πŸ‘‰ www.mdpi.com/2076-2615/15...

Do current influenza rapid tests work for H5 (in humans)? All were able to detect bovine H5N1, with ranging sensitivities. πŸ‘‰ www.medrxiv.org/content/10.1...

What do we know about wild bird associated "pathogens" (noting that not all microbes are pathogens!)? For some more than others, but suitable habitat index + climatic factors played crucial roles in shaping the distribution of pathogens πŸ‘‰ www.sciencedirect.com/science/arti...

paper-based LAMP for H5 with detection f 1000 copies when spiked into OP swab samples, achieving 100% analytical sensitivity, specificity, and accuracy πŸ‘‰ www.nature.com/articles/s41...

Japan, 2022–23 winter, >1,500 endangered cranes, including hooded crane + white-naped crane debilitated or dead. Genomes distinct from poultry viruses. Serology suggests limited contribution of herd immunity. πŸ‘‰ wwwnc.cdc.gov/eid/article/...

Interested in HPAI in the Antarctic? Ive undertaken a considerable update on my website, which includes a detailed list of publication and some key links, analysis and interpretation. πŸ‘‰ www.michellewille.com/avian-influe...

Great to see more HPAI genomes from the Antarctic - here an HPAI genome sequenced on board an expedition demonstrating similarity to genomes from South Georgia (and dissimilar from the S. Shetlands). πŸ‘‰ journals.asm.org/doi/10.1128/...

Updated joint FAO/WHO/WOAH public health assessment of H5 πŸ‘‰global public health risk as low πŸ‘‰in people who are exposed to infected birds or mammals, risk from low to moderate πŸ‘‰pandemic potential requires enhanced vigilance πŸ‘‰ www.who.int/publications...

Detailed assessment of skua HPAI related mortality in Marguerite Bay, Antarctica. Critically, show the utility of rapid tests and concordance with PCR testing. πŸ‘‰ www.biorxiv.org/content/10.1...

After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors. www.nature.com/articles/s41...

Such a useful paper demonstrating how to do influenza diagnostics. Very relevant for all those setting up HPAI screening in Antarctica, or new to the field. πŸ‘‰ www.nature.com/articles/s41...

🌧️🌡 Climate extremes are reshaping the world of pollinators! A new study reveals that a decrease or excessive increase in water availability can negatively affect the reproductive potential of plant species & pollinators collecting their nectar. 🌍πŸ§ͺ Learn more: www.nature.com/articles/s41...

Our manuscript "Colonizers on the road: European bee-eaters shift nest-site selection to roadside habitats" has been accepted for publication in Ecology @ecologicalsociety.bsky.social! @ebdonana.bsky.social #DoΓ±ana #RoadEcology

@haraipapilio.bsky.social paper on evolution of Wolbachia MK mechanism through prophage acquisition in molina butterflies - avoiding suppression by the host. Now out! #symbiosky www.sciencedirect.com/science/arti.... With @daisukekageyama.bsky.social @bolinabug.bsky.social and others

Confirmed findings of avian influenza in non-avian wildlife in 2025 www.gov.uk/government/p... Interesting that mortality of grey seals at Blakeney wasn't above expected during pupping, but of 40 carcasses 37.5% were HPAI

Excited to share β€œBin Chicken”, substantially improving genome recovery through rational metagenomic assembly. Applied to public 🌍 metagenomes, it recovered 24,000 novel species 🦠, including 6 novel phyla. doi.org/10.1101/2024... @wwood @rhysnewell @CMR_QUT 🧡1/6

human nasal epithelial cells challanged with human influenza + H5N1. HPAI less adapted to human nasal cells, and elicited unique host responses = subdued antiviral activity, subdued wound healing, compromised epithelial barrier integrity, etc πŸ‘‰ doi.org/10.1080/2222...

Domestic ducks in regular contact with wild birds screened in the Phillipines: 2.3% IAV (8/348 pools), with detection of HPAI H5N6, LPAI H5N8. πŸ‘‰ ojs.wpro.who.int/ojs/index.ph...

mAbs generated against HA of H10N7 in mice which have neutralisation ability in vivo = potential drugs for clinical antiviral therapy πŸ‘‰ link.springer.com/article/10.1...

Investigation into the consequences of mass mortalities in elephant seals. newborn mortality has limited impact, consequences of pup mortality unknown until 2027. Large consequences for mature female mortality. Decades to return to pre-HPAI population πŸ‘‰ onlinelibrary.wiley.com/doi/abs/10.1...

Decay of HPAI H5N1 in milk evaluated, and heat treatment whereby inactivation in all tested conditions, except for thermization at 50 °C for 10 min. Submerged coil system confirmed inactivation using commercial pasteurisation approaches. πŸ‘‰ www.nature.com/articles/s41...

Nanobodies identified via yeast two hyrbid system had high affinity and broad neutrilisation capacity against 2344b + 2321. Had prophylactic and therapeutic efficacy in mice = potential therapeutic πŸ‘‰ journals.asm.org/doi/full/10....

Modelling of HPAI in henhouses at different transmission (Ro) with implementation of vaccination. Vaxx keeps mortality low, importance of maternal antibodies. But, if highly transmissible, mortality will increase despite vaccination. πŸ‘‰ www.sciencedirect.com/science/arti...

CVV H5N8 use for vaccination in mice. Inactivated CVV w MH59, IM, twice at 7 day interval induced strongest response and protected mice. πŸ‘‰ www.mdpi.com/1999-4915/17...

To contextualise H5N6 human case, sampling undertaken in LBM in China. 2344b H5N6 & H5N1 detected. H5N6 similar to wild bird viruses and human case πŸ‘‰ link.springer.com/article/10.1...