edgenome.bsky.social
The Genomics & Bioinformatics Core Facility at the University of Edinburgh
https://genomics.ed.ac.uk/
51 posts
538 followers
356 following
Regular Contributor
Active Commenter
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Edinburgh Genomics is committed to enhancing genomics and bioinformatics technologies, driving innovation and groundbreaking research across academia, healthcare, and industry
Want to see how we could help your research?
✉️[email protected]
➡️https://genomics.ed.ac.uk/
🧵 (6/6)
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A massive shout out to our extraordinary team, whose unmatched dedication, exceptional skills, and tireless efforts continue to drive our success. Their innovative thinking and relentless pursuit of excellence make all of this possible 🧫 💻🧬
🧵 (5/6)
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We're proud not just of our research output but of our role in educating hundreds of scientists through our training programs, and by supporting undergraduate and PhD students at @EdinburghUni 👩🎓
Check out our offerings: genomics.ed.ac.uk/service/trai...
🧵 (4/6)
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Our deepest gratitude goes to @BBSRC for their unwavering support, particularly in equipping us with advanced long-read sequencing technologies that empower our continued mission to advance bioscience research in the UK. 🌱🧪
🧵 (3/6)
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Special thanks to Professor Mark Blaxter and @BioMickWatson, founders of Genepool and ARK-Genomics respectively, which later merged to become Edinburgh Genomics. Our appreciation also to @timaitman, who established our Clinical Genome Facility. 🎓✨
🧵 (2/6)
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📢 Ready to get started? 💻 Register & book now: genomics.ed.ac.uk/equipment-ac...
#EdinburghGenomics #Genomics #Sequencing #OpenAccess 🖥️🧬🧪🔬💻
🧵6/6
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✨ Why choose us?
✅ Access cutting-edge equipment with expert training.
✅ Hands-off options with our comprehensive services.
✅ Explore advanced techniques like adaptive sampling.
✅ Expert support to elevate your research.
#Genomics #Sequencing #OpenAccess
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✨ What’s it like using open-access equipment?
📸 Here’s @rivkamlim.bsky.social using our @nanopore #PromethION!
🧵4/6
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DNA Nanopore Sequencers
Oxford Nanopore PromethION P24 & MinION 👉 Whole-genome long-read sequencing 👉 Direct RNA sequencing & metagenomics
Real-Time PCR
Applied Biosystems 7500 FAST 👉 qPCR for absolute/relative quantitation, NGS library quantitation, & gene expression
🧵3/6
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Electrophoresis – Size Separation Analysis
Agilent Tapestation & Bioanalyser 👉 DNA/RNA QC, PCR analysis, NGS QC
Sonication
Covaris LE220 👉 Shear/fragment DNA/RNA
Size Selection
Sage BluePippin & SageELF 👉 DNA size selection for NGS 👉 Whole-sample fractionation
🧵2/6
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Missed out this time? Join our next instance in May! genomics.ed.ac.uk/event/introd...
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Ready to revolutionize your research? 🌟
Contact Edinburgh Genomics today to learn how our pangenome analysis can transform your work.
✉️[email protected]
#Genomics #Bioinformatics #Pangenome
🧵4/4
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4️⃣ Expert Support:
Collaborate with leading #genomics & #bioinformatics specialists for actionable insights.
Why choose us?
Accelerate discoveries 🚀
Gain a competitive edge 💡
Get end-to-end support 🔗
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1️⃣ Comprehensive Insights:
Identify core & accessory genes for a complete view of genetic variation.
2️⃣ Tailored Solutions:
Custom analyses for human, plant, animal, & microbial genomes.
3️⃣ Advanced Technology:
High-resolution, scalable analyses using the latest tools.
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🎁 Why are biologists great at Christmas shopping?
They know how to find the best deals on genes!
🎁 Why did the petri dish stay under the mistletoe?
It was hoping for a little culture!
#BiologyJokes #ScienceHumor #FestiveFun
#ScienceChristmas #ChristmasCrackerJokes
⛄️⛄️⛄️⛄️⛄️
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We’re excited to see what new insights emerge from these advances! 🚀
Want to know more about using Jasmine and Fiber-seq in your projects? Let’s chat!
📧 [email protected]
#FiberSeq #Genomics #Epigenetics #LongReadSequencing #Bioinformatics
🧵6/6
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With @pacbio.bsky.social’s Jasmine software, we can now offer 6-base calling (ATCG+5mC+6mA) on the #Revio platform—at no extra cost in sequencing consumables. 🔬🙌
Learn more about Jasmine: github.com/PacificBiosc...
#FiberSeq #Genomics #Epigenetics #LongReadSequencing #Bioinformatics
🧵5/6
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📚 Case Study:
A new paper uncovers how repeat-region instability disrupts nearby regulatory elements, revealing a disease mechanism and potential therapeutic target in #MyotonicDystrophy
Read more: biorxiv.org/content/10.1...
#FiberSeq #GeneRegulation #Genomics #Epigenetics
🧵4/6
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@pacbio.bsky.social or @nanoporetech.com sequencing captures this signal, and with new software and resources to interpret the Fiber-seq data our view into the mechanisms of gene regulation has never been clearer.
Learn about the tools:
github.com/fiberseq/FIRE
fiberseq.github.io/index.html
🧵3/6
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In the Fiber-seq protocol, chromatin accessibility is revealed by treating the DNA with non-specific N6-adenine methytransferase to create an m6A fingerprint on the DNA itself.
Learn more: stergachislab.org/research
#FiberSeq #GeneRegulation #Epigenetics
🧵2/6
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We love sharing our passion for #science and #genomics! 🧬🖥️
If your club, group, or school is interested in learning more or chatting with our amazing scientists, get in touch: [email protected].
We’d love to connect! 📚✨
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At Edinburgh Genomics, we’re passionate about making cutting-edge science accessible, and inspiring future scientists. 🌍🔬
This term alone, we’ve hosted lab tours, been interviewed by students, and helped to introduce bioinformatics and lab-based genomics skills to students! 🧬🖥️
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Embarking on an #AMR project? 🦠
At Edinburgh Genomics, our expert team is here to help you plan, execute, and analyse your experiments. Plus, we’re lucky to collaborate with fantastic networks within the University community like @uoe-eid.bsky.social to drive impactful research forward.
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How can we prevent AMR? ✅
💊Use antibiotics only when prescribed.
✅Complete the full course of treatment.
🚿Practice good hygiene to prevent infections.
🔬Support development of new diagnostics & treatments.
Together, we can fight #AMR! 🌍💪 #WAAW2024
🧵6/7
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How does AMR happen? 🔬
When antimicrobials are overused or misused, microbes adapt to survive. Key drivers include:
💊Unnecessary prescriptions
⌛️Not finishing treatment
🐮Overuse in agriculture
🦠Poor infection control
(figure from: weforum.org/stories/2024...)
🧵5/7
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How do bacteria become antibiotic-resistant?🦠
1️⃣ Mutations to protect them from antibiotics.
2️⃣ Horizontal gene transfer to share resistance genes with other bacteria.
Antibiotic use creates selective pressure, favouring resistant strains.
DOI: 10.1126/science.aax3879
🧵4/7
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What is #AMR? 🦠
Antimicrobial Resistance (AMR) happens when bacteria, viruses, fungi, or parasites evolve to resist the medicines we use to treat infections. This makes diseases harder—or even impossible—to treat. 💊 #WAAW2024 #AMRAwarenessWeek
🧵3/7
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Inspired yesterday by @uoe-eid.bsky.social’s Winter Lecture with Prof. Alison Holmes from Imperial College on tackling #AMR with a systems-level approach. 🌟
Exciting insights into rapid diagnostics & biosensors for real-time monitoring—truly the future of #AMRscience! 🔬💡 #WAAW2024
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