gl-hooper.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🚨 FINALLY OUT IN @Nature. A tour de force effort. 🦇 10 new bat genomes, excess of immune gene adaptations, species specific adaptations in ISG15, and anti-SARS-CoV-2 activity of bat ISG15. @hillermich.bsky.social @batresearch.bsky.social #LZCI #Bat1K www.nature.com/articles/s41...

submitted 30 days ago • 5 comments

Researchers captured MOKV and IKOV glycoproteins in pre- and post-fusion states, revealing pH-induced changes in membrane fusion. This study presents the first solved IKOV structure. journals.plos.org/plospathogen... #virology #Lyssavirus #IKOV #MOKV

submitted 23 hours ago • 0 comments

Hell yeah! Virion X is a game-changer in virology research. Making vital info accessible is a smart move for innovation and public health. Can't wait to see the impact! 🚀💡 #Biotech #Disruption

submitted 1 day ago • 0 comments

🚀 Exciting news! We’re launching Virion X, a biotech dedicated to making critical virology research more accessible. We’re building a waitlist so you’ll be the first to know when we go live. lnkd.in/emSCjXcY #VirionX #Virology #Pseudotyping #Biotech #startup #pseudotypedvirus

submitted 2 days ago • 0 comments

Researchers have developed a recombinant ASFV-based bivalent vaccine candidate that protected against lethal challenges from both ASFV and CSFV in pigs. www.tandfonline.com/doi/10.1080/... #ASFV #CSFV #Vaccine #VaccineDevelopment #virology #veterinaryvirology

submitted 4 days ago • 0 comments

Researchers engineered a stable, prefusion Lassa virus GPC trimer, which, when used as an immunogen in animal models, elicited robust neutralizing antibody responses. www.nature.com/articles/s41... #virology #vaccine #LassaVirus #VaccineDevelopment #Immunology #EmergingViruses #Glycoprotein

submitted 4 days ago • 0 comments

This study identifies potent mAbs with strong neutralising activity against SARS-CoV-2. 2YYQH9 & LQLD6HL reduced lung pathology in XBB.1.16-infected hamsters, showing promise for future therapies. #pseudotyping #COVID19 #mAbs #virology🔗 translational-medicine.biomedcentral.com/articles/10....

submitted 5 days ago • 0 comments

This preprint uses pseudotyped virus deep mutational scanning to map HIV escape mutations against two broadly neutralising antibodies, 10-1074 & 3BNC117, revealing strain-dependent differences. #HIV #virology #antibodies #pseudotyping #pseudotypedvirus www.biorxiv.org/content/10.1...

submitted 8 days ago • 0 comments

This paper looks at population immunity to SARS-CoV-2 in south Africa following the emergence of the Beta VOC, using spike binding and pseudotyped virus neutralisation assays. #virology #pseudotyping #COVID19 #Immunology #Antibodies www.nature.com/articles/s41...

submitted 9 days ago • 0 comments

New preprint on canine viromes in Australia led by @jonathonmifsud.bsky.social. Includes the first RNA virus reported in dingoes - an unusual rotavirus A. Domestic dogs worldwide seem to carry a pretty similar set of viruses. www.biorxiv.org/content/10.1...

submitted 10 days ago • 0 comments

www.cell.com/cell/abstrac...

submitted 10 days ago • 0 comments

Nice review on African swine fever virus vaccine development. www.mdpi.com/1422-0067/26... #asfv #virology #vaccine

submitted 11 days ago • 0 comments

Novel Bridge Protein Strategy for Cell-Specific Delivery of Pseudotyped Viruses. #virology #pseudotyping #pseudotypedvirus #tropsim #proteinengineering www.sciencedirect.com/science/arti...

submitted 11 days ago • 0 comments

Amantadine analogues inhibit drug-resistant influenza A: blocking pseudotyped virus entry & disrupting M2-M1 interactions. Promising for future antivirals for drug-resistant IAV. www.sciencedirect.com/science/arti... #Influenza #Antivirals #DrugResistance #Virology #pseudotyping

submitted 15 days ago • 0 comments

Targeting SARS-CoV-2 spike HR2: Researchers designed HR212, a recombinant protein that inhibits viral infection across 28 pseudotyped variants. This highlights its potential as a broad-spectrum antiviral. #COVID19 #virology #pseudotyping #antiviralresearch onlinelibrary.wiley.com/doi/10.1002/...

submitted 17 days ago • 0 comments

Developing a high-titre VSV-based pseudotyped virus for HCoV-NL63, researchers enhanced infection efficiency by truncating the spike protein, which they use for antiviral screening. www.sciencedirect.com/science/arti... #Virology #Pseudotyping #DrugDiscovery

submitted 19 days ago • 0 comments

Great concise review of African swine fever virus. It highlights the ongoing threat of African Swine Fever, recent advances in diagnostics and vaccine research, and the persistent challenges in controlling its spread. #ASFV #virology pubmed.ncbi.nlm.nih.gov/39713833/

submitted 22 days ago • 0 comments

This preprint explores how past SARS-CoV-2 exposure shapes immunity. Adults imprinted by early strains target RBD, while XBB*-infected infants focus on NTD. Vaccination shifts infants’ response to RBD but with different targets. #virology #COVID19 www.biorxiv.org/content/10.1...

submitted 25 days ago • 0 comments

This study reveals that Sudan ebolavirus glycoprotein binds to the human NPC1 receptor ~9 times more strongly than Ebola virus glycoprotein. Identifying 4 key residues that differ in binding from EBOV. #virology #EbolaVirus #SUDV www.nature.com/articles/s42...

submitted 26 days ago • 0 comments

A new bivalent VSV-based vaccine targets SARS-CoV-2 & influenza A, inducing strong immune responses in mice. It protects against both viruses & cross-protects against flu strains, offering promise for a broad-spectrum respiratory vaccine. #Vaccines #pseudotyping www.science.org/doi/10.1126/...

submitted 30 days ago • 0 comments

This study examines WCBV and LLEBV in Miniopterus schreibersii across Europe, highlighting WCBV's significant risk and the urgent need for surveillance due to ineffective rabies vaccines and treatments. #virology #RABV #WCBV #lyssavirus www.cell.com/iscience/ful...

submitted 33 days ago • 0 comments

Nano-acoustics could enable viral fingerprinting via ultrafast spectroscopy. Vibrations at 19–21 GHz reveal morphology/protein interactions, while 2–10 GHz modes track disassembly. This label-free method could advance diagnostics and research. #virology #pseudotyping www.pnas.org/doi/10.1073/...

submitted 36 days ago • 0 comments

A study on vampire bat rabies in Latin America (1970–2023) shows rising cross-species transmission post-2002, signaling re-emergence. Rabies causes 450 cattle outbreaks/year, hitting Brazil, Colombia, Peru & Mexico hardest. journals.plos.org/plosone/arti... #Rabies #RABV #virology

submitted 37 days ago • 0 comments

This recent study used pseudotyped virus assays to show that DCoVs enter DF-1 cells via clathrin-mediated endocytosis, relying on clathrin, dynamin-2, cathepsins, and low pH, while independent of caveolae/macropinocytosis. #pseudotyping #virology veterinaryresearch.biomedcentral.com/articles/10....

submitted 38 days ago • 0 comments

This paper outlines a protocol to assess humoral immune responses in mice post-SARS-CoV-2 vaccination. It features ELISA for spike-specific binding antibodies and a pseudotyped virus neutralization assay for neutralizing titers. #pseudotyping #COVID19 #vaccine www.sciencedirect.com/science/arti...

submitted 40 days ago • 0 comments

Maikoo et al. have developed a HIV-1C latency model. Revealing that the HIV-1C consensus LTR exhibited a lower reactivation potential compared to its HIV-1 subtype B counterpart. #Virology #pseudotyping #HIV www.sciencedirect.com/science/arti...

submitted 43 days ago • 0 comments

Check out our recent review on "Cell entry mechanisms of African swine fever virus" #ASFV #virology www.sciencedirect.com/science/arti...

submitted 44 days ago • 0 comments

This study identified a natural diketopiperazine/piperidine alkaloid that inhibits pseudotyped and live SARS-CoV-2, SARS-CoV-2 XBB, SARS-CoV, MERS-CoV, and HCoV-HKU1 by targeting spike protein RBD-ACE2 interactions. #COVID19 #pseudotyping www.sciencedirect.com/science/arti...

submitted 44 days ago • 0 comments

A recent study revealed SARS-CoV-2 variants with the E484D spike mutation can bypass ACE2, using host lectins ASGR1 and DC-SIGN for cell entry. This pathway resists imdevimab treatment and could impact therapeutic strategies. journals.asm.org/doi/10.1128/... #pseudotyping #COVID19

submitted 45 days ago • 0 comments

A Phase I trial shows an optimized srRNA rabies vaccine is safe, effective, and works at lower doses or with one shot. Offering ~10x dose-sparing and durable immunity, this innovation could boosts vaccine accessibility and compliance. www.nature.com/articles/s41... #Vaccines #Virology

submitted 47 days ago • 0 comments

This study used pseudotyped and live viruses to assess the chimeric mAb 7-H7-B1, which blocks CD209 and CD209L. 7-H7-B1 effectively inhibited infections from SARS-CoV, SARS-CoV-2, Ebola, Marburg, ZIKV, and DENV in vitro. #pseudotyping #virology onlinelibrary.wiley.com/doi/10.1111/...

submitted 50 days ago • 0 comments

🚨 New preprint alert 🚨 We searched for the presence of coronaviruses in >200 bat individuals across Spain 🦠🦇. We recovered 6 complete coronavirus genomes, including 3 novel species. One of them could use bat and human ACE2 for entry. www.biorxiv.org/content/10.1...

submitted 51 days ago • 0 comments

It’s official: The Microbiology Society is on Bluesky!

submitted 52 days ago • 6 comments

A recent study analysed neutralisation assays across 15 labs using the WHO SARS-CoV-2 antibody standard. Three live neutralisation assays and a pseudotyped assay showed excellent consistency, including between live and pseudotyped virus assays. #pseudotyping #virology www.mdpi.com/1999-4915/16...

submitted 51 days ago • 0 comments

To get 2025 off to a good start, I'm delighted to share with you our study published today in @naturemicrobiol.bsky.social 🎉 We studied the ability of the receptor-binding proteins (RBP) of >100 animal viruses to mediate entry into human cells. A short thread below. www.nature.com/articles/s41...

submitted 58 days ago • 3 comments

This preprint employed pseudotyped virus deep mutational scanning to examine how mutations in the rabies glycoprotein affect cell entry and neutralisation by eight monoclonal antibodies. #pseudotyping #rabv www.biorxiv.org/content/10.1...

submitted 71 days ago • 0 comments

ClickVSV, a fluorescent pseudotyped vesicular stomatitis virus, enables the visualisation and tracking of cell binding and entry in living cells, unlike conventional pseudotyped viruses. pubs.acs.org/doi/10.1021/... #pseudotyping #virology #fluorescence

submitted 72 days ago • 0 comments

This recent paper utilised Marburg and Ebola virus pseudotypes to develop small molecule entry inhibitors at CL-2, before validating and optimising hits with live virus at CL-4, perfectly demonstrating the usefulness of pseudotyped viruses pubs.acs.org/doi/10.1021/... #pseudotyping #virology

submitted 72 days ago • 0 comments

This review highlights the utility of pseudotyping in gene therapy, particularly how pseudotyping with different viral envelope proteins enables cell-specific delivery of CRISPR-Cas9, facilitating targeted gene editing. #pseudotyping #genetherapy www.sciencedirect.com/science/arti...

submitted 75 days ago • 0 comments

Potential therapeutic against African swine fever virus. #ASFV #virology pubmed.ncbi.nlm.nih.gov/39638605/

submitted 77 days ago • 0 comments

Neutralizing antibody assays play a vital role in assessing COVID-19 vaccine efficacy. This recent review explores three neutralisation assay types: conventional virus, pseudotype virus, and surrogate virus assays. mdpi.com/2076-393X/12... #COVID19 #VaccineResearch #pseudotyping

submitted 79 days ago • 0 comments

Trans-synaptic tracing is a technique that utilises pseudotyped viruses to identify synaptically connected neurons in neural circuits. Great to see pseudotyping being applied beyond virology. #pseudotyping #neuroscience Here's an example paper. www.pnas.org/doi/10.1073/...

submitted 85 days ago • 0 comments

Hot off the pre-press! Unbiased selection of alphacoronavirus 🦠 spikes plus pseudotype entry assays with 25+ receptors (🦇🐈🐶🐒🚶‍♀️...). Receptor host range can vary dramatically between closely-related viruses, plus many alphaCoVs don't seem to use known receptors at all: www.biorxiv.org/content/10.1...

submitted 96 days ago • 2 comments

"Cellular sialoglycans are differentially required for endosomal and cell-surface entry of SARS-CoV-2 in lung cell lines" journals.plos.org/plospathogen...

submitted 87 days ago • 0 comments

ClickVSV, a fluorescent pseudotyped vesicular stomatitis virus, enables the visualisation and tracking of cell binding and entry in living cells, unlike conventional pseudotyped viruses. pubs.acs.org/doi/10.1021/... #pseudotyping #virology #fluorescence

submitted 87 days ago • 0 comments

This preprint published on bioRxiv introduces a method to enhance lentiviral (LV) gene delivery by dual-pseudotyping LVs with VSV-G and αFITC-Env whilst labelling target cell surfaces with FITC. #pseudotyping #GeneDelivery www.biorxiv.org/content/10.1...

submitted 88 days ago • 0 comments