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gregorgorjanc.bsky.social
Managing and improving populations using data science, genetics and breeding: @HighlanderLab, @RoslinInstitute, & @TheDickVet. https://www.ed.ac.uk/roslin/highlanderlab
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We selected for large body size in black soldier flies. Across three replicates the phenotypic response to selection was similar - faster growth, more protein and 15% larger body size. But the genetic changes were highly polygenic and mostly different between replicates

In #NextGenSequencing news, big announcement today from Ultima Genomics with their new UG100 Solaris instrument. 50% more data, and now going from the $100 genome to the $80 genome (30x human coverage). www.prnewswire.com/news-release...

We had a great time at the Gordon Research Conference on Quantitative Genetics and Genomics in Lucca www.grc.org/quantitative... this week! Daniel Tolhurst's abstract was selected for a talk: Disentangling Non-Crossover and Crossover Genotype by Environment Interaction for Selection

Wow. This is sooo good. Echoing @urbanevol.bsky.social this user’s manual for Ne should be required reading for popgen and conservation genetics folks. onlinelibrary.wiley.com/doi/10.1111/...

PostDoc position in evolutionary genomics available with Dan MacQueen at the Roslin Institute in Edinburgh, part of our BBSRC sLoLa on rediploidisation following whole genome duplication

Last week some of us attended the 1st EAAP - European Federation of Animal Science Insect Genetics Workshop, which was organised with InsectIMP CA22140 COST Action action by Gertje Petersen and Jana Obšteter. We presented

🐧 Last week we wrapped up our Linux for Genomics workshop! Participants mastered essential shell skills, from file management to powerful tools like samtools & bedtools. 🖥️🧬 Missed this one? Join us for the next session! 👉 genomics.ed.ac.uk/event/introd... 📸

A pair of manuscripts from Sharon Browning on applications of IBD segments for mapping disease-associated loci and detecting natural selection. www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

If you organize a meeting, session, or seminar series and are open to speaker suggestions in genetics or computational biology, especially junior faculty approaching tenure who would really benefit from the exposure, please message me for names.

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

LLMs + #RStats are a powerful combo. I wrote a little post about using R to curate GitHub data and {ellmer} to program with LLMs to automate one of my least favorite tasks: remembering what I did this week. www.garrickadenbuie.com/blog/llm-wor...

Sharing for a friend. Job opening, Université de Montréal, Institut de recherche en biologie végétale (IRBV). Assistant Prof in Quantitative Genetics. #PlantSci www.nature.com/naturecareer... Apply by March 9. Should speak French or be willing to learn!

New pre-print: “Leveraging ancestral recombination graphs for quantitative genetic analysis of rice yield in indica and japonica subspecies” by Ines Rebollo, Jana Obsteter, Daniel Tolhurst, Juan Rosas, and me www.biorxiv.org/content/10.1...

FlexLMM: a Nextflow linear mixed model framework for GWAS https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaf021/7954687 🧬🖥️🧪 https://github.com/birneylab/flexlmm

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

HighlanderLab at PopGroup58 in Sheffield! It’s always interesting to attend the highly diverse set of talks and posters on population genetics and associated fields at the PopGroup conference. This year it was hosted by the University of Sheffield. We contributed with two talks and four posters.

I have now also ported the color vision deficiency simulation app to Shiny live. Advantage is this runs entirely in your browser, even though you "upload" the image it never leaves your computer.