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hamishs.bsky.social
Analyzer evangelist and mass spectrometry enjoyer. Read about the Astral analyzer: https://pubs.acs.org/doi/10.1021/acs.analchem.3c02856
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Posts 8 Comments 42

Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates. They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice. www.biorxiv.org/content/10.1...

submitted 1 day ago • 4 comments

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

submitted 42 days ago • 2 comments

Enlightening and accessible work from Josh Coon's group. It's good to see comparisons coming up. Wonder how many more Olink proteins would be shared with the deeper multi-fraction Seer/Astral analysis with 6k IDs.

submitted 43 days ago • 1 comment

New publication by Serrano et al. describes deep analysis of the human proteome in less than 1 hour! This paper describes the process and how it takes advantage of the new Orbitrap Astral mass spec high acquisition speeds. www.mcponline.org/article/S153...

submitted 52 days ago • 0 comments

With this manuscript we would like to demonstrate the incredible power of the Orbitrap Astral for XL-MS. Over 40% more IDs than the Orbitrap Eclipse! This opens up a completely new dimension for XL-MS. www.biorxiv.org/content/10.1...

submitted 66 days ago • 0 comments

Typing through gritted teeth.

submitted 75 days ago • 0 comments

We thank the reviewers for their suggestions and believe they have substantially improved the paper

submitted 78 days ago • 192 comments

My ceiling tiles are fantastic. The best. Hardly ever do workmen come in, lift the ceiling, and spray particulate crap into my instruments.

submitted 83 days ago • 0 comments