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hansclevers.bsky.social
Scientist interested in Wnt signaling, stem cells and organoids Currently, head of Roche's Pharma Research and Early Development at the Basel headquarter. Advisor to my labs in Utrecht at the Hubrecht Institute and the Princess Maxima Center
14 posts 863 followers 19 following
Getting Started

Snake venom gland organoids. Study by Yorick Post and collaborators. www.sciencedirect.com/science/arti... Image credit: Anne Rios

a human liver organoid

#Lgr5+ gut #stemcells don't divide asymmetrically. They simple divide and then compete for space: This is called neutral competition. Stem cell numbers are set by the available space between the #Panethcells. Paper: Hugo Snippert et al. Cell (2010). www.cell.com/action/showP...

📢Roche's Institute of Human Biology seeks 2 visionary scientific leaders: Head of Computational Biology & Head of Exploratory Biology. Drive pioneering research, shape scientific strategy and lead innovation at the crossroad of academia and industry!🔗https://go.roche.com/ls0un #organoids #TeamIHB

Ik was in Basel voor een interview met @hansclevers.bsky.social “Het is een proces van eindeloze een-tweetjes. En bij de start van de eerste fase van het klinisch onderzoek moet je al in je hoofd hebben wat voor patiëntengroep je over zes jaar wilt behandelen.” www.newscientist.nl/blogs/een-me...

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex... New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

trying out to post an animation: #organoids in #Matrigel dome

Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue