haoyin.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

#CatSky😸 #EvoDevo A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell & calico cats ARHGAP36 #XChromosomeInactivation ➖corr. #Melanogenesis @currentbiology.bsky.social 2025 www.cell.com/current-biol... 😸credit www.newsweek.com/rare-unicorn...

submitted 13 hours ago • 1 comment

Building better #brain models. "With organoids, assembloids and a growing toolkit of bioengineering tricks, scientists are stitching together models of the developing human brain — and pushing the limits of realism and control." 🧪 🧠 #science #neuroskyence #biology www.nature.com/articles/d41...

submitted 3 days ago • 0 comments

The #genetics of orange coloration of tortoiseshell and calico cats. Did you know that the orange phenotype of domestic cats helped to discover X-linked inheritance in mammals? Read here about the molecular bases of this familiar phenotype in cats. 🧪 🧬 #Science #Biology www.cell.com/current-biol...

submitted 1 day ago • 0 comments

I don’t usually make desserts, but when I do, they are healthy, gorgeous, and for special people in my life. This one was for Iris. The most special of all. #MedFoodSky #SpousesOfDoctors

submitted 18 hours ago • 1 comment

snRNAseq post-stroke brain repair Photothrombotic stroke 1 mo post injury Stroke core vs border zone vs intact Pleiotrophin signaling in Stroke ⏬EC-immune/-progenitor/-astrocyte ⏫Pericyte-progenitor/-astrocyte @rrust.bsky.social #JNeuroInflam 2025 link.springer.com/article/10.1...

submitted 19 hours ago • 0 comments

🇦🇺🦘Just wrapped up 6 incredible weeks of science, collaboration at the University of the Sunshine Coast. Thanks to Vicki Hinkley for such a productive partnership—I’m excited to continue this collaboration across 🇩🇰 and 🇦🇺. I’m also grateful to the USC CONNECT Programme for the funding 🙏

submitted 3 days ago • 0 comments

#MetaplasticBreastCancer #DiffusionWeightedMRI 29🚺 19 squamous + 8 mesenchymal +unclassified histo-type #ApparentDiffusionCoefficient & tumor size mesenchymal > squamous Likely associated with⏬5-y overall/disease-free survival Dar-Ren Chen lab @plosone.org 2025 journals.plos.org/plosone/arti...

submitted 1 day ago • 0 comments

journals.biologists.com/jcs/article/...

submitted 1 day ago • 0 comments

⏬Mechanosensing & ⏫inflammation of aortic #EndothelialCell as a potential disease driver in #MarfanSyndrome 😎 A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk ⏬pSMAD2 ↔️pERK1/2 #AortaEd Hiromi Yanagisawa lab #CircRes 2025 www.ahajournals.org/doi/suppl/10...

submitted 1 day ago • 0 comments

Super excited to share our latest work on visualising actin networks through ultrastructure expansion microscopy. A major leap towards high-resolution visualisation of the actin cytoskeleton. Grateful to @syncellbiolab.bsky.social and @anubhavdhar.bsky.social for giving me this opportunity!

submitted 2 days ago • 1 comment

Guidelines for mouse experiments of thoracic #Aortopathy👹 Great literature synthesis of genetic & chemical models of🐭 #ThoracicAorticAneurysm #AorticDissection Must-read for all Aorta researchers😎 @alandaugherty.bsky.social #ATVB 2025 @ahajournals.bsky.social www.ahajournals.org/doi/full/10....

submitted 2 days ago • 0 comments

Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...

submitted 3 days ago • 2 comments

This review came just in time for me to get work on some #Marfan experiments!

submitted 2 days ago • 1 comment

Guidelines for mouse experiments of thoracic #Aortopathy👹 Great literature synthesis of genetic & chemical models of🐭 #ThoracicAorticAneurysm #AorticDissection Must-read for all Aorta researchers😎 @alandaugherty.bsky.social #ATVB 2025 @ahajournals.bsky.social www.ahajournals.org/doi/full/10....

submitted 2 days ago • 0 comments

Registration has started for the conference "Emerging Trends in the Physics of the Cell" in memoriam of Erich Sackmann at TU Munich from October 15-18 2025 www.cpa.tum.de/cpa/conferen...

submitted 48 days ago • 2 comments

Devastating cuts in funding for science, engineering and biomedical research at US universities will cripple the US economy for years to come.

submitted 2 days ago • 1 comment

Issue 9 is complete! Cover: Neuronal connections in control (left) and Klp61F neuronal knockdown (right) Drosophila larval brains, labelled with photoconvertible EOS-tagged tubulin. Spectrum color-coded hyperstacks of z-stack images show relative spatial positions of neurons doi.org/10.1242/dev....

submitted 2 days ago • 1 comment

🔬✨ Today for #FluorescenceFriday: A close-up of the dorsal part of the first gill arch in a mature zebrafish. The intricate vascular network supporting respiration, visualized using kdrl:mcherry. #Zebrafish #DevBio #Microscopy #Fluorescence #SciArt

submitted 2 days ago • 3 comments

NIH-funded basic research allowed me to discover two molecules (COX-2 and S1PR1) that became drug targets - COX-2 inhibitors and S1PR modulators - more than 7 million prescriptions for Celebrex taken for pain; >350k people have taken Fingolimod/Ozanimod for MS and IBD/UC-basic research is essential!

submitted 2 days ago • 0 comments

#DBfeature The localization and function of the moonlighting protein Clathrin during oocyte maturation by Beatrice Camia, Manuela Monti et al www.sciencedirect.com/science/arti...

submitted 2 days ago • 0 comments

SIMO Integration of multimodal single-cell omics (incld SNARE-seq ISSAAC-seq) with #SpatialTranscriptomics Modality-specific kNN + fused G-W #OptimalTransport vs CARD LIGER Scanorama Seurat Tangram Spatial ATAC-RNAseq Spatial CUT&TAG-RNAseq #NatComm 2025 www.nature.com/articles/s41...

submitted 2 days ago • 0 comments

Is IDOL an Ideal Target for Treating Atherosclerosis? ATVB. www.ahajournals.org/doi/full/10....

submitted 59 days ago • 0 comments

Trophoblast to Spiral Artery Communication Trophoblast-derived IL-1β⏫#EndothelialCell MMP10 secretion (likely help periendothelial matrix decomposition) MMP10⏬ in decidua of🤰with high risk of #Preeclampsia #FASEBJ 2025 faseb.onlinelibrary.wiley.com/doi/full/10....

submitted 3 days ago • 0 comments

Anyone have access to this PDF from Nature Reviews Disease Primers that they'd be willing to share (not on sci-hub as far as I can tell)? www.nature.com/articles/nrd...

submitted 3 days ago • 1 comment

Calcineurin is a phosphatase implicated in AngII-induced abdominal aortic #aneurysm (AAA). This study reveals a novel, phosphatase-independent mechanism by which #Calcineurin contributes to AAA, dependent on transcriptional reprogramming of #SmoothMuscleCells @plosbiology.org 🧪 plos.io/4kfnT3L

submitted 3 days ago • 0 comments

Mechanoregulation of lymphocyte cytotoxicity www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins. New study from Yumeng Wan, Yuri Nemoto, Kazuya Tsujita, Toshiki Itoh and colleagues (Kobe University): rupress.org/jcb/article/... #Membrane #lipid #Cytoskeleton #Biochemistry #Biophysics

submitted 3 days ago • 0 comments

Today!! NAVBO Journal Club on May 15 at 1:00 pm ET Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in T2DM-associated atherosclerosis Presented by Alonso Tapia, City of Hope Paper: tinyurl.com/5adxbtzj Event: tinyurl.com/mw3ua2f7 navbo.org/calendar

submitted 3 days ago • 0 comments

#EndothelialCell Robo4 👉⏬irradiation-induced #EndMT 👉Modulates #HematopoieticStemProgenitorCell quiescence & lineage potentials Evidence of bEND3🐭microvascular EC Robo4-KD EC coculture▶️ HSPC ⏫G0 quiescence ⏫apoptosis ⏫Erythrocyte ⏫Megakaryocyte #CellDeathDis 2024 www.nature.com/articles/s41...

submitted 3 days ago • 0 comments

High-resolution optical imaging of the meninges within the brain of an adult zebrafish. Credit to @zebrafish007.bsky.social & #WeinsteinLab. #ZebrafishZunday 🧪

submitted 7 days ago • 3 comments

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/cor... Paper link below 👇

submitted 4 days ago • 5 comments

Hippocampal vasculature is so pretty 😍 (mouse hippocampus perfused with Tomato Lectin and cleared) #Neuroscience #Microscopy

submitted 4 days ago • 2 comments

#MetaplasticBreastCancer #CaseReport 70 y/o Irregular, heavily calcified mass pT2N1aM0 Lumpectomy adjuvant Chemo (FEC-Tx) & Radio 2.5 mm carcinoma, 1/9 lymph node invaded, no dist meta Chondroid differentiation Lympho-vascular involvement Ann Med Surg 2025 journals.lww.com/annals-of-me...

submitted 4 days ago • 0 comments

Exciting career opportunity: Senior Scientist I (Peter Gilgan Chair in Neuroregeneration Research) – University Health Network in Toronto. can-acn.org/senior-scien... #neurojobs

submitted 4 days ago • 1 comment

www.biorxiv.org/content/10.1... New manuscript alert from our lab. We show that #lipiddroplets serve as depots for active translation, and that these are regulated as a host response to infection! PhD work of Rakesh Jha from our lab.

submitted 4 days ago • 1 comment

At ASGCT this week, anyone else here?

submitted 4 days ago • 2 comments

#DBfeature #Drosophila JNK Kinase regulates cachexia like syndrome in scribble knockdown tumor model of Drosophila melanogaster by Rohit Kumar, Saripella Srikrishna www.sciencedirect.com/science/arti...

submitted 4 days ago • 0 comments

SETDB1-mediated H3K9me3 deposition represses the transcription of evolutionary conserved #ShortInterspersedNuclearElement SINE B2 (containing CTCF binding sites) in🐭#NeuralPrecursorCell #GenomBiol 2024 genomebiology.biomedcentral.com/articles/10....

submitted 4 days ago • 0 comments

Imaging the microstructure of the arterial wall – ex vivo to in vivo potential Thanks for citing our #EHJOpen paper on #DiffusionTensorImaging #MTI #ThoracicAorticAneurysm ex vivo 😆 academic.oup.com/ehjopen/arti... Caitriona Lally lab #ActaBio 2025 www.sciencedirect.com/science/arti...

submitted 5 days ago • 0 comments