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heankel.bsky.social
Scientist interested in gene regulation by condensates in the 🧠 | Postdoc with Aaron Gitler @Stanford | PhD @UTSW studying IDR-IDR specificity in transcriptional condensates | 🇲🇽
4 posts 776 followers 2,204 following
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Posts 13 Comments 4

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...

submitted 11 hours ago • 7 comments

Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social rdcu.be/ebbZf

submitted 21 hours ago • 2 comments

Today @nature.com on how pancreatic cancer can hijack our nervous system and how denervation may be therapeutic www.nature.com/articles/s41...

submitted 8 days ago • 3 comments

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...

submitted 13 days ago • 4 comments

Very proud of our first peer-reviewed paper from the lab: a review on the multifaceted role of RNA-binding proteins in the metabolic control of stem cells. Check it out! This is a truly amazing effort by my PhD student Ellie Koletsou @mpiage.bsky.social #proudPI doi.org/10.1038/s443...

submitted 42 days ago • 3 comments

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

submitted 69 days ago • 21 comments

👀 Less than 24 hours! Don't forget to register!

submitted 70 days ago • 0 comments

As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...

submitted 90 days ago • 2 comments

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

submitted 96 days ago • 6 comments

Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday! We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇

submitted 98 days ago • 2 comments

Trying for a molecular and cellular neurobiology starter pack - happy to add folks and connect :) #neuroskyance #cellbiology go.bsky.app/PgEk7aF

submitted 106 days ago • 48 comments

I am excited to share our review published online with Nature Reviews MCB. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length scale assemblies of complexes (Figure 1). www.nature.com/articles/s41...

submitted 99 days ago • 3 comments

Biomolecular condensate starter pack! Trying to compile & to bring together biomolecular condensate enthusiasts & critics! Please join this non-exhaustive (sorry!) collection & just ping me for addition. #condensates, #phaseseparation, #granules, #IDPs go.bsky.app/NFqmffa

submitted 100 days ago • 18 comments