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jackiheraudfarlow.bsky.social
RNA biologist working at Hudson Institute in Melbourne. Interested in intersection of RNA modifications (A-to-I editing), dsRNA structure and RBPs with innate immunity and autoinflammatory disease. She/her.
57 posts 1,518 followers 1,135 following
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RNA xkcd.com/3056

submitted 4 days ago • 161 comments

Today is Rare Disease Day Rare diseases affect millions worldwide, often with limited treatment options. Rare Voices Australia (RVA) advocates for those living with rare diseases, connecting them to vital resources. Learn more: rarevoices.org.au Five rare diseases and support groups:

submitted 3 days ago • 1 comment

Cool stuff @cp-cell.bsky.social by @raflynn5.bsky.social & friends on presence & functions of glycoRNA microdomains on the plasma membrane! 👇👇👇

submitted 3 days ago • 0 comments

Wow, looking forward to reading this one. Do the spliced TEs trigger nucleic acid sensors like PKR or MDA5? #RNASky #ImmunoSky

submitted 11 days ago • 1 comment

Attention all Melbourne #RNA researchers. The next RNAVic minisymposium is now open for FREE registration. To be held at @hudsonresearch.bsky.social on March 27th with a great lineup of local speakers from research and industry. This is an RNA salon event supported by @rnasociety.bsky.social.

submitted 12 days ago • 0 comments

#RNAsky #RNAbiology

submitted 23 days ago • 0 comments

#IL_NAT25 Yuval Dor on RNA editing in diabetes. Thought inflamation caused by virus, but no virus found. Can initial process that lead to diabetes trigerred by endogenous dsRNA induced inflamation? Data indicates yes, by ADAR KO mouse model. Phenotype similar to progression of diabetes in humans

submitted 25 days ago • 1 comment

The world of RNA modifications expands again! ADP-ribosylation discovered in the arms race of host-pathogen interactions. #RNASky #Immunosky

submitted 23 days ago • 0 comments

Waiting for flight back to Oz and reflecting on the awesome @keystonesymposia.bsky.social last week on #RNA mediated regulation of #immunity. Here are a few highlights with links to the published or preprinted papers which you should definitely check out if you haven't yet ... #RNAsky #Immunosky

submitted 26 days ago • 3 comments

Really enjoyed reading in #MolecularCell "RNA sensing induced by chromosome missegregation augments anti-tumor immunity" They found dsRNA sensing is equally important in the #interferon response to micronuclei induced by inhibition of spindle assembly. www.sciencedirect.com/science/arti...

submitted 40 days ago • 1 comment

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention #RNAbiology #RNAlocalization www.nature.com/articles/s41...

submitted 55 days ago • 0 comments

Proud to share our paper on the impact of transcription inhibition on mRNA export in cancer. A big thanks to collaborators, especially to Ewa Michalak, Vi Wickramasinghe, Jeff Chao and Mark Dawson @mafdawson.bsky.social. @fmiscience.bsky.social

submitted 58 days ago • 1 comment

At this END of YEAR please check out our new paper on GENE ENDS and a convenient marker of transcription termination: RNAPII CTD T4ph! We think it is relevant to anyone studying human/animal #genes and #genome so put a lot of effort to make it easy to read. #RNABiology and #Epigenetics meet:)

submitted 65 days ago • 1 comment

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

submitted 71 days ago • 4 comments

RNA sensing induced by chromosome missegregation augments anti-tumor immunity www.cell.com/molecular-ce...

submitted 73 days ago • 0 comments

Efficient circular RNA synthesis for potent rolling circle translation. Congratulations to Yifei and the team in Venki's lab at @mrclmb.bsky.social! www.nature.com/articles/s41... #RNA #RNABiology #RNAsky #Translation #mRNA

submitted 74 days ago • 0 comments

Very important study to consider in light of the many miRNA cancer network and association studies out there!

submitted 75 days ago • 0 comments

Heading to @3rrrfm.bsky.social radio to discuss some of our science on #innateimmunity #inflammation #RNA sensing and what this could mean for new #mRNA therapies. If you’re in Australia, tune into Einstein-A-GoGo this morning at 11 am. Podcast link to follow! @hudsonresearch.bsky.social #immunosky

submitted 78 days ago • 0 comments

Another year, another science-themed cake for the @hudsonresearch.bsky.social CiiiD EOY party! This edible board game is made from gingerbread & royal icing, with a hidden medovik (honey cake) inside! It was a labour of love but lots of fun to make! #sciencesky #immunosky #bakingsky #sciencebakes

submitted 78 days ago • 1 comment

Very cool story! A good example of how chasing the weird thing you see in sequencing data can lead to exciting new discoveries. #RNASky #RNABiology #ImmunoSky

submitted 79 days ago • 0 comments

Out of the oven from my group! APAtizer, to simplify the analysis of alternative polyadenylation events using RNA-Seq data: academic.oup.com/bioinformati...

submitted 80 days ago • 0 comments

Hello Bluesky 🤠 Our very first post is about our recent paper in Nucleic Acids Research: so-called PUN motifs are repetitive elements enabling proteins to catalyze #RNA folding and RNA-dependent #condensate formation ( #LLPS). 15% of human proteins contain 3 or more PUN motifs. See bit.ly/4fZ3f54.

submitted 80 days ago • 1 comment

SERVICE UPDATE We normally don't ask you to "share like and subscribe" but please distribute this. You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research. #AcademicSky #Medsky #HigherEd

submitted 81 days ago • 9 comments

Really beautiful RNA structures from Rachel Kretsch in the Das and Chiu groups These look like viral capsids but they're only RNA!! Hopefully this unlocks more work on "ornate" RNAs 🧪 www.biorxiv.org/content/10.1...

submitted 81 days ago • 3 comments

Who else is coming to this #KSRNAImmune25? I'm very excited for a conference covering my two favourite topics, RNA and Immunity all in one! #RNASky #ImmunoSky #RNABiology www.keystonesymposia.org/conferences/...

submitted 82 days ago • 0 comments

www.cell.com/molecular-ce... #RNASky #RNAbiology

submitted 86 days ago • 0 comments

Excited to share this #Insight we wrote with Erika Valeri for @jexpmed.bsky.social on works by Chan et al. (hubs.la/Q02-JGLM0) & Ru et al. (hubs.la/Q02-JK4r0) that identify defective RNA processing as the root cause of impaired antiviral immunity in the human brainstem rupress.org/jem/article/...

submitted 86 days ago • 0 comments