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New study by Luján et al. from Vivek Malhotra's group @crg.eu (rupress.org/jcb/article/...) details the molecular mechanism of a rare illness that causes transient paralysis and dangerous arrhythmias. More in the news @elpais.com: english.elpais.com/science-tech...

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Our March issue is here! 👉 buff.ly/41BpGc8 Cover shows transmission electron #microscopy image of a Vero E6 cell showing the formation of double membrane vesicles (yellow) 6 hours post-infection with #SARSCoV2. From Yang et al. (buff.ly/4ifC9rE)

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RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking, say Shuai Liu, Jie Wei, Yanling Yan, Anbing Shi and colleagues (Huazhong University of Science and Technology): buff.ly/3QuXAZQ

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Cells secrete proteins that cannot enter the ER–Golgi secretory pathway. Curwin, Kurokawa et al. show that Golgi membranes are recycled to create new compartments that lack Golgi-specific glycosyltransferases and function to collect and sort cargo for secretion. buff.ly/3F0XvLa

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Mutations in the TANGO2 gene cause severe cardiomyopathies and rhabdomyolysis, particularly under stress. Lujan, Malhotra et al. @crg.eu demonstrate that TANGO2 is an acyl-CoA binding protein located in the #mitochondria lumen. buff.ly/4bqM7UP

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ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq

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HLS, an autosomal recessive #ciliopathy, is associated with a mutation in the centriole protein HYLS1. Curinha, Holland et al. show that HYLS1 mutant mice exhibit developmental abnormalities, with #centriole integrity & #cilia assembly defects https://buff.ly/3XlIry1

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Velez-Aguilera and Jantsch discuss work by tthe Dumont lab (https://buff.ly/3Xj2a14) that utilized sophisticated imaging approaches of #Celegans embryos undergoing #meiosis to reveal the existence of an "interkinetic envelope" in oocytes during interkinesis. https://buff.ly/41gPVmP

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Cisterna et al. show that prolonged depletion of profilin 1 or F-#actin causes an adaptive response in #microtubules. https://buff.ly/4jpCgSQ In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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An S-acylated N-terminus and a conserved loop regulate the activity of the ABHD17 de-acylase, say Sydney Holme, Jennifer Sapia, Stefano Vanni @labvanni.bsky.social, Elizabeth Conibear and colleagues: https://buff.ly/4b3E0xy #Biochemistry #Membrane and #lipid

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New study from Liu and Wei et al. (Huazhong University of Science and Technology) shows how RAB-10 and EHBP-1 proteins form a molecular "capture system" in epithelial cells. This newly discovered mechanism controls how vital cargo moves through exocytic compartments. https://buff.ly/3QuXAZQ

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de Leeuw, Budhathoki, Russell, Loerke & Blankenship examine the mechanical limitations that nuclear volumes impose on epithelial remodeling in #Drosophila. https://buff.ly/4gyiW3j In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation, say Miho Matsuda and Sergei Sokol: https://buff.ly/4hX8aVo #Polarity #Development #CellSignaling

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Chong et al. @dumontlabucsf.bsky.social show that chromosomes biorient and correct errors with varying efficiencies. Chromosome size and the spindle forces that scale with size determine error correction efficiency. https://buff.ly/4gCpY7c In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Zhou, Kengaku et al. identify Nesprin-2 as a bidirectional motor adaptor during nuclear migration in developing #neurons. https://buff.ly/42S0BL5 In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Single-molecule #lipid #biosensors mitigate inhibition of endogenous effector proteins, say Victoria Holmes, Morgan Ricci, Gerald Hammond (@gerryhammond.bsky.social) and colleagues: https://buff.ly/4jWbCkI

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The LC3-interacting region of NBR1 is a protein interaction hub enabling optimal flux, say Brian North, Christopher Shoemaker and colleagues: https://buff.ly/4b0ETa4

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Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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When one nucleus is not enough: Intestinal polyploidy fuels healthier progeny in C. elegans. Priya Sivaramakrishnan discusses work from Lessenger, @mpswaffer.bsky.social, Feldman and colleagues (https://buff.ly/4jQweLl) in Spotlight: https://buff.ly/4jQwb27

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NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends. New study from Sabina Colombo, Thomas Surrey @surreylab.bsky.social and colleagues @crg.eu: https://buff.ly/41aj9F9

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Thanks @sdgilk.bsky.social and @jcb.org for highlighting our work!

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Cytosolic companionship: Rickettsia connects with the endoplasmic reticulum. Stacey Gilk @sdgilk.bsky.social @unmccom.bsky.social highlights work from Acevedo-Sánchez et al. @lamasonlab.bsky.social (https://buff.ly/3CUnh2M) in Spotlight: https://buff.ly/40M2hTK

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Nguyen, Otani, Furuse et al. show that tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex. https://buff.ly/3CMvVAt In #Mechanobiology 2025: https://buff.ly/3EK0uaq

submitted 14 days ago • 1 comment

Structure of the F-tractin-F-actin complex. A new study by Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner @uni-muenster.de, and Alexander Belyy @alexanderbelyy.bsky.social @unigroningen.bsky.social: https://buff.ly/3EIqAur #Cytoskeleton #StructuralBiology #Biochemistry #Actin

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ABHD17 enzymes remove fatty acids from #membrane proteins like NRas. New work from Holme, Sapia, @labvanni.bsky.social, Conibear et al. show that their activity depends on two mobile regions: an S-acylated N-terminal helix and a loop. https://buff.ly/4b3E0xy

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New work from Matsuda and Sokol suggests that the core planar cell polarity protein Prickle2 cooperates with environmental cues to promote anisotropic remodeling of apical junctions, leading to neural tube closure in Xenopus embryos. https://buff.ly/4hX8aVo

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Caillier, @pwoakes.bsky.social et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. https://buff.ly/4jU4e9C In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Some real all-stars in this collection!!

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Pan et al. find that actomyosin-II–driven reversible beading underpins the resilience of central axons to mild mechanical stress by suppressing the propagation & firing of injurious Ca²⁺ waves https://buff.ly/3EBKsj5 In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Focused ion beam scanning electron 🔬 cross-section image at 5-nm resolution of part of three human iPSC-derived neurons. The surface-rendered endolysosome (yellow) reveals a limiting membrane perforated by a small nanopore, visible as a black hole. @kirchhausenlab.bsky.social https://buff.ly/42B7KiL

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VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b. New study from Paolo Sanzà, Judith Klumperman @judithklumperman.bsky.social and colleagues @umcutrecht.bsky.social: https://buff.ly/4guSZ4H

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Orii & Tanimoto study the structural mechanics of #microtubule and #actin cytoskeletons using high-force intracellular magnetic tweezers. https://buff.ly/4hWVPR8 In #Mechanobiology 2025: https://buff.ly/3EK0uaq

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Our new #Mechanobiology collection examines the mechanical properties & interactions that shape the fundamental operations & structures of cells. Delve into diverse mechanical properties of membranes, organelles & other structures within & among cells 👉 https://buff.ly/3EK0uaq

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Spotlight: Priya Sivaramakrishnan discusses work from Lessenger, @mpswaffer.bsky.social et al. (https://buff.ly/4jQweLl), which shows that regulated #polyploidy in the #Celegans intestine is important for modulation of transcript levels, cell size, and tissue function. https://buff.ly/4jQwb27

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Spotlight: @sdgilk.bsky.social highlights work from Acevedo-Sánchez et al. @lamasonlab.bsky.social (https://buff.ly/3CUnh2M) revealing that the cytosolic bacterial pathogen Rickettsia parkerii hijacks host machinery to form stable membrane contact sites with the ER. https://buff.ly/40M2hTK

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New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9

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New: Holmes, Ricci, @gerryhammond.bsky.social et al. show that AKT activation is blocked by commonly used PIP3 #biosensors, but that this can be overcome by expressing biosensors at single molecule levels - which also improves kinetic fidelity and sensitivity. https://buff.ly/4jWbCkI

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The most frequently asked question we get: do #lipidtime genetically encoded lipid biosensors compete out cells’ native effector proteins? Victoria Holmes and Morgan Ricci led a paper in JCB that answers this question: rupress.org/jcb/article/... Read on for a brief thread.

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New: Using F-tractin to visualize #actin in living cells? Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner, and Alexander Belyy @alexanderbelyy.bsky.social determined the F-tractin-F-actin structure and showed that this probe is nearly identical to #Lifeact. https://buff.ly/3EIqAur #cytoskeleton

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New: North, Shoemaker et al. define the LC3-interacting region (LIR) of NBR1 as a multifunctional binding site that recruits ATG8 proteins, FIP200, and TAX1BP1 to drive autophagic flux. https://buff.ly/4b0ETa4 #Biochemistry #autophagy

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Check this nice preview from Roy Parker's group on a surprising new view of Cajal Bodies! The paper discussed here, from Karla Neugebauer, exemplifies the power and genius of engineering the right control for your question.

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New: Sanzà, @judithklumperman.bsky.social et al. reveal a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. https://buff.ly/4guSZ4H

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So happy to see this finally out!

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New: Prifti et al. @elowesab.bsky.social @universitelaval.bsky.social show that the Rho exchange factor TEM4 regulates progression though the #CellCycle in G1 via the pro-proliferative transcription factor #YAP. https://buff.ly/40ZDBZg

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I couldn't dream of a better opportunity than helping bring good research to publication in the most respected cell biology journal 🙏🏻

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We are pleased to introduce the newest members of the JCB Editorial Board: Anna Akhmanova, @msubrandizzilab.bsky.social, @goleylab.bsky.social, @christlet.bsky.social, @olzmannlab.bsky.social, Marisa Otegui, Christian Ungermann, Chonglin Yang, and Yan Zhao. https://buff.ly/3Q1O0NT

submitted 28 days ago • 1 comment

Our February Issue is here! 👉 https://buff.ly/4aI3csU The cover shows a 12× 3D-ExM 🔬 image of metaphase PtK2 cells stained for DNA, Hec1 & #microtubules, providing a high-resolution visualization of the #microtubule-#kinetochore interface. 📸 By Norman, Suzuki et al. https://buff.ly/4aFLGFM

submitted 28 days ago • 0 comments

Happy holidays with Holey Endosomes. We share our work using 3D EM demonstrating that tiny perforations in endosomes in neurons allow access of cyrtosolic alpha-synuclein to endocytosed alpha-synuclein pre-formed fibrils, thereby triggering toxic alpha-synuclein aggregation.

submitted 64 days ago • 1 comment

Happy to see this collab with the Loerke lab out in @jcb.org - congrats to Katie, Liam, Dinah, and all coauthors. Read more about "rectifying" interfaces here: doi.org/10.1083/jcb....

submitted 32 days ago • 1 comment

New: Peters, @sarawickstrom.bsky.social et al. show that epidermis-specific deletion of CerS4 prevents development of the adult hair follicle bulge stem cell compartment due to altered differentiation trajectories, resulting in hair loss and impairment in skin barrier. https://buff.ly/4hzxkJw

submitted 32 days ago • 0 comments