Profile avatar
leonsmyth.bsky.social
CNS immunology, stroma, and barriers | postdoc in @kipnislab @WUSTL | Kiwi 🥝 🇳🇿 | incoming @Monash 2025
20 posts 1,006 followers 277 following
Prolific Poster

Monash University has made many positions available specifically for young and early career researchers who would like to take some time away from the USA. These are case by case, not advertised. So if you are interested or know anyone interested have them get in contact with someone at Monash.

I am delighted to share that our work focused on anti-tumor immunity in the leptomeningeal space was published today: www.nature.com/articles/s41... @meningojan.bsky.social

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Review @cp-immunity.bsky.social @jonykipnis.bsky.social Glymphatics and meningeal lymphatics unlock the brain-immune code www.cell.com/immunity/ful...

Australia should be doing this now and at a grander scale. Let’s reverse the brain drain and properly support the scientists we have @markbutlermp.bsky.social @edhusicmp.bsky.social

Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.

Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code

🧬The interactive RNA sequencing resource from the Daneman Lab is now live!🧬 Built by Ben Gastfriend, this user-friendly tool lets you explore gene expression changes across multiple conditions! Check it out here: danemanlab.shinyapps.io/bbbtranscrip...

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

Heterogeneity in pericyte inflammatory responses across age and species highlight the importance of human cell models molecularbrain.biomedcentral.com/articles/10....

Redefining CNS immune privilege🫶 www.nature.com/articles/s41...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

Redefining CNS immune privilege - Nature Reviews Immunology www.nature.com/articles/s41...

Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

This is a trainee seminar series and your participation is very important and much appreciated. Join us next week. Here is the free registration link: streamyard.com/watch/wHnr7P...

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity www.science.org/doi/10.1126/...

#ReThinkNeuroimmunology 3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology. Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Registrations 🔗 genelayinstitute.org/rtn/

🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis www.nature.com/articles/s41...

Great new work led by @biomarina-vg.bsky.social on zebrafish meninges! Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn! Congrats Marina & team on this great work! 🦓🐟🧠

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

🚨 A new Daneman Lab preprint!! 🚨 Reid Larsen, one of the brightest scientists I know, studied the BBB glycocalyx, identified its structure, composition, and function and uncovered what makes the CNS glycocalyx unique. It was a true pleasure to be a part of this seminal study! shorturl.at/Wkhxr

Meningeal regulatory T cells inhibit nociception in female mice @science.org www.science.org/doi/10.1126/...

Tau lesions in chronic traumatic encephalopathy (CTE) are also sites of concentrated glial reactivity. In our recent paper published in Acta Neuropathological we used multiplex immunohistochemistry to explore the microenvironment of these lesions link.springer.com/article/10.1...

If you're at #ADPD2025 come see us at poster 564 (Chelsie) and 587 (me)

Great story covering our description of the superficial glia limitans! @thetransmitter.bsky.social : www.thetransmitter.org/astrocytes/u...

A group leader position is open at Peter Mac in Melbourne, Australia! Join us! Applications until May 5. 👇👇 www.nature.com/naturecareer...

Run a lab at an international cancer research centre in Melbourne, Australia! Applications open until May 9th…. 👇👇👇

Meningeal lymphatics-microglia axis regulates synaptic physiology: @cellpress.bsky.social www.cell.com/cell/fulltex....

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || www.sciencedirect.com/science/arti...

Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium https://go.nature.com/4hrHX0v

@mmr2.bsky.social talk is now on YouTube! "The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis " CBDM lab @HarvardMed www.youtube.com/watch?v=eZTP...

🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!! www.nature.com/articles/s41...

Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025... We hope this method is useful to a wide range of the biology community.

Excited to share this paper that is a long time coming from the lab on epigenetic/transcriptional regulation of organotypic endothelial specialization out today @naturecvr.bsky.social go.nature.com/4krSJqh

Meeting the person you suspect is reviewer #2 in a conference

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

Some excellent thoughts here...

When you look at the audience trying to guess who your reviewer might be

We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in Melbourne, Australia 🔬🦘💥 Work in a cutting edge research environment in a vibrant world city! We value research excellence, creativity and diversity. Join us! careers.petermac.org/job/MELBOURN...

Very happy to share the link to the full article of my recent work www.science.org/stoken/autho... Had fun visualizing this complex dataset! Excited to hear your thoughts and explore new insights or other creative ways to reuse the data!

Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.

Rest and rinse: sleeping rhythms drive brain detox #immunology

Our News and Views on @nataliehauglund.bsky.social and Maiken Nedergaard's recent study showing how sleep drives brain waste clearance @cp-trendsimmuno.bsky.social www.cell.com/trends/immun...