leonsmyth.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease www.nature.com/articles/s41...

submitted 2 hours ago • 0 comments

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

submitted 2 days ago • 1 comment

The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors https://www.biorxiv.org/content/10.1101/2025.02.22.639649v1

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The aging human brain exhibits reduced cerebrospinal fluid flow during sleep due to both neural and vascular factors

submitted 2 days ago • 1 comment

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

submitted 4 days ago • 1 comment

State of funding into universities and research in NZ continues to get worse, with more cuts about to be announced. www.stuff.co.nz/politics/360...

submitted 5 days ago • 1 comment

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer @jem.org @simoncleary.bsky.social doi.org/10.1084/jem....

submitted 6 days ago • 0 comments

In @elife.bsky.social: Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish doi.org/10.7554/eLif...

submitted 6 days ago • 0 comments

Our latest in PNAS! 🎉 ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Take home message? KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions. www.pnas.org/doi/10.1073/...

submitted 7 days ago • 6 comments

We have a postdoc position available in the lab! Come and work on lymphatic vascular development and regeneration. We use zebrafish, mouse, cells, tumour models and love imaging, genetics and genomics🔬 Come join us in Melbourne! www.seek.com.au/job/82157187...

submitted 7 days ago • 0 comments

Pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after stroke 🧪🧠 www.nature.com/articles/s41...

submitted 8 days ago • 0 comments

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke www.nature.com/articles/s41...

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submitted 12 days ago • 1 comment

The locus coeruleus is located in the brainstem and is among the first regions in the human 🧠 to acquire pathology in Alzheimer's disease. Loss of neurons in the locus coeruleus is directly linked to cognitive decline. 🟢TH labels noradrenergic neurons; 🟣 pTau labels neurofibrillary tangles 🔬👩‍🔬🧪

submitted 14 days ago • 2 comments

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

submitted 20 days ago • 9 comments

NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization

submitted 20 days ago • 1 comment

NEW Review: B cells in non-lymphoid tissues by Abrar Samiea @georgecelis.bsky.social Rashi Yadav @laurenrodda.bsky.social @joshuamoreau.bsky.social Highlighting new insights into mechanisms of tissue B cell function and immunotherapeutic targets #immunology #immunosky

submitted 20 days ago • 0 comments

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition @nature.com www.nature.com/articles/s41...

submitted 21 days ago • 0 comments

Microglial plasticity governed by state-specific enhancer landscapes www.biorxiv.org/content/10.1...

submitted 22 days ago • 0 comments

The neurorepellent SLIT2 inhibits LPS-induced proinflammatory signaling in macrophages @jimmunol.bsky.social academic.oup.com/jimmunol/adv...

submitted 24 days ago • 0 comments

And it's out! The BIC lab presents our new perspective article on "Immune Control of Brain Physiology" - fresh off the press at @natrevimmunol.bsky.social nature.com/articles/s41... wonderful synergy: @marikovacs.bsky.social @amaia-db.bsky.social and @fakesamir.bsky.social

submitted 26 days ago • 1 comment

New preprint now online! www.biorxiv.org/content/10.1... We created an algorithm to detect NREM sleep micro-arousals and used it to re-analyze LFP data from the motor cortex of sleeping mice 💤 This is what we found:

submitted 27 days ago • 1 comment

Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis https://www.biorxiv.org/content/10.1101/2025.01.25.634888v1

submitted 29 days ago • 0 comments

1/ New in #ScienceImmunologyResearch! We explored how the brain maintains equilibrium with the immune system. Our focus? The key player in immune tolerance and tissue function regulation: regulatory T cells (Tregs). Let’s dive in! www.science.org/doi/10.1126/... @immunoeditor.bsky.social

submitted 28 days ago • 3 comments

Meningeal regulatory T cells restrain local interferon-γ–producing lymphocytes, thereby safeguarding parenchymal brain homeostasis @sciimmunology.bsky.social @mmr2.bsky.social www.science.org/doi/10.1126/...

submitted 29 days ago • 1 comment

A comprehensive atlas of AAV tropism in mice www.cell.com/molecular-th... @moltherapy.bsky.social

submitted 29 days ago • 0 comments

We have two postdoc positions in the lab: We are looking for neuroscientist with expertise in circuits, and for molecular virologist. If you are excited to apply your expertise to questions in neuroimmunology, please reach out for details. Please retweet.

submitted 32 days ago • 0 comments

Another postdoc starting his own lab. Li-Feng Jiang-Xie is on his way to @pennmedicine.bsky.social to start his lab on neuroscience of sleep and brain clearance. Amazing science to come!

submitted 32 days ago • 0 comments

Kicking off the new year searching for a postdoc to join our team @wehi-research.bsky.social Apply now and spread the word

submitted 42 days ago • 0 comments

My team produced some truly stunning images of the brain this year using multiplexed immunohistochemistry. These two won awards at our Faculty of Medical & Health Sciences image competition #FluorescenceFriday

submitted 45 days ago • 3 comments

Adult zebrafish meningeal vasculature. Credit to @biomarina-vg.bsky.social. #ZebrafishZunday 🧪

submitted 45 days ago • 0 comments

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social erictopol.substack.com/p/our-sleep-... open-access

submitted 45 days ago • 48 comments

Out in @cellcellpress.bsky.social ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 www.cell.com/cell/fulltex...

submitted 47 days ago • 2 comments

Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

submitted 48 days ago • 0 comments

The stories behind out research are mostly hidden, since they are typically not part of the papers we write. Could we include these creative background stories in a section of the research paper format, maybe just as online supplements? What do you think? open.substack.com/pub/matthias...

submitted 48 days ago • 2 comments

How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...

submitted 48 days ago • 16 comments

Such a cool study linking the striking vascular pulsations in sleep to neurochemical oscillations, ultimately driving CSF clearance. Understanding the role of other sleep stages (eg REM) in clearance, and how sleep architecture cooperates to clear the brain will be super interesting in the future.

submitted 48 days ago • 0 comments

New: Papadopoulos, Kipnis and colleagues present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. https://buff.ly/40724ub

submitted 48 days ago • 0 comments

Excited having this work out. It may explain many discrepancies in the field. This data made me think of the yoga head stand… not sure it’s a good thing… luckily I can’t do them anymore 😉

submitted 48 days ago • 0 comments

Credit is infinitely divisible in academia: the more authors on a paper, the merrier. Middle authors contribute so much and share in the credit, while that doesn’t take away any of the credit from the lead contributors.

submitted 48 days ago • 3 comments

Taking 5 min from my 2-week 🎅 Holidays break 🥂 to share our new review out today 🤓 the hard work of 3 super talented 🧪 PhD students Béatrice Laura & *Valérie covering implication of 🧠 #vascular #BBB cells in #anorexia #stress #depression #Parkinson #Alzheimer www.sciencedirect.com/science/arti...

submitted 60 days ago • 0 comments

Fluid pathophysiology in the CNS following lymphatic dysfunction with implications for development of therapeutic strategies targeting lymphatics in neurological disease @jexpmed.bsky.social @jonykipnis.bsky.social doi.org/10.1084/jem....

submitted 49 days ago • 0 comments

A really 🔥 topic ! "The pathobiology of neurovascular aging" www.cell.com/neuron/fullt... #cerebrovascular

submitted 49 days ago • 1 comment

Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular

submitted 51 days ago • 0 comments