Profile avatar
lifeonthewedge.bsky.social
Staff scientist @biozentrum.unibas.ch using algorithms to look at tiny stuff inside cells, or #cryoET if you prefer. Here I talk mostly about my research. Views my own. 🇧🇷 in 🇨🇭
52 posts 296 followers 574 following
Prolific Poster
Conversation Starter

Dear #Basel friends, on May 10th @apbstudio.bsky.social is once more organizing the #WorldCollageDay celebration ✂️🤩 Join us for a relaxing and fun afternoon of #collage making at the Foyer Public of the Theater Basel!

Hey @florentwaltz.bsky.social @verenaresch.bsky.social @cellarchlab.com, looks like you've launched a trend of animated covers at @science.org 😎

Em português ambas se chamam academia

A elite paulista passeando em Amsterdam.

To all #ChlamyDataset enthusiasts, here is a script that lets you directly import the pre-processed results from EMPIAR-11830 into #RELION v5 for subtomogram averaging: github.com/Chromatin-St... #Chlamydomonas #TeamTomo #CryoET #OpenSoftwareAcceleratesScience

Dear all, I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!

One of the coolest side projects out there 😉

This structure is absolutely _nuts_. Lipids are captured marching through the tunnel

I do genuinely wonder how many people think what happened with Wikipedia is that “society accepted it” rather than that they put a ton of work into making it reliable, something that is not going to make AI reliable because no technology to actually understand meaning has been or can be invented.

PhD Timeline xkcd.com/3081

"Geneticists and others must stand against a global rise of white nationalism, which seeks to leverage scientific racism for eugenicist goals, and stop its talking points from entering the mainstream political discourse." ➡️ www.nature.com/articles/d41...

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

On dispensing with journal names as quality proxies: "If you can do it for people who have lived and breathed Cell [HHMI], you can do it for anyone" ht @leslievosshall.bsky.social youtu.be/_S6JvhKm7qY?...

Caí no esquema de pirâmide do Substack

Same energy: há pouco tempo saiu uma crítica sobre Ainda Estou Aqui num dos maiores jornais suíços dizendo que o filme pecava por retratar apenas uma família branca da elite brasileira e não "aqueles que mais sofreram" com a ditadura: os pobres, pretos e indígenas. (...)

Using embroidery, yarn, and wool, Peruvian artist Ana Teresa Barboza creates textile art depicting land and seascapes #womensart

Sunlight powers almost every organism on #Earth, directly or indirectly. Scientists are still uncovering the mysteries of life’s intimate bond with solar radiation. 🧵 Credit: Josue Moura Romao/Nature in Motion

We have updated our #MemBrain v2 preprint with a lot more details about the MemBrain-pick and MemBrain-stats modules, as well as some application examples! Stay tuned for the upcoming thread by lead author @lorenzlamm.bsky.social! 🧠🧵 #CryoET #TeamTomo www.biorxiv.org/content/10.1...

Read preprints. Cite preprints. Email people and tell them you loved their preprint. Email people you hated their preprint. Embrace preprints, preprints are good.

A última linha de defesa entre a realidade e a mentirada cuspida pelos geradores de lero-lero é a noção de cada um. Com a qual, na maior parte dos casos, é impossível contar.

This is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.

FeS clusters have never been so pretty 🤩 Congrats @rnfr2d2.bsky.social @schullerjm.bsky.social and the whole team on this superb work!

This is insane! 🧬🧵🤯

Wow, the world's largest direct air capture facility! 500,000 tonnes of CO₂ per year is a time machine that takes us back ~6 minutes. 🥲 www.1pointfive.com/projects/ect...

The SNSF welcomes #Switzerland’s retroactive association to #HorizonEurope from 1 Jan 2025, enabling researchers to join nearly all calls following the Federal Council’s approval of the EU Programmes Agreement. Find out more here ➡️

Basel and phages, what not to love 🦠💘

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues. www.science.org/doi/10.1126/...

Happy to share that our work on the structure and regulation of the Glutamine synthetase from methanogenic archaea is now out in @elife.bsky.social elifesciences.org/articles/97484

Luiz Sacilotto, Concretion 58, 1958 #artbots #moma https://botfrens.com/collections/14377/contents/1137736

www.biorxiv.org/content/10.1... NEW PREPRINT ALERT! Thanks to all involved!

CEMOVIS revisited! 🙂

Podem me chamar de otimista, mas um país que viveu 20 anos de ditadura militar hoje tornou réu um ex presidente por tentativa de golpe de estado. Nossa democracia não está saudável, mas ainda está viva. g1.globo.com/politica/not...

And this for the lab who was instrumental in developing COVID vaccines. Simply outrageous

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

Molecular machines enable efficient energy production in mitochondria. Using cryo-electron tomography @cellarchlab.com and @florentwaltz.bsky.social have gained insight into the architecture of mitochondria at unprecedented resolution. @snsf-ch.bsky.social www.biozentrum.unibas.ch/news/detail/...

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...