lisannemout.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

We'll be seeing a lot more of this—epigenetic editing—in the future www.nature.com/articles/s41...

submitted 16 hours ago • 1 comment

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less' Lots of interesting new TE (& genes) biology Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

submitted 4 days ago • 8 comments

Check out our latest preprint! Interested in Androgen Receptor, gene regulation and TRIM proteins? Well, in that case, I believe you’ll like this story! www.biorxiv.org/content/10.1...

submitted 8 days ago • 0 comments

Now online in Cancer Discovery: The Germline and Somatic Origins of #ProstateCancer Heterogeneity - by Takafumi Yamaguchi, Kathleen Houlahan, Helen Zhu, Natalie Kurganovs, Julie Livingstone, Natalie Fox, Niall Corcoran, Juri Reimand, Christopher Hovens, Paul Boutros, et al. doi.org/10.1158/2159...

submitted 12 days ago • 0 comments

Happy International Day of Women in Science. The National Science Foundation’s list of flagged words includes both “Women” and “Female.”

submitted 14 days ago • 28 comments

Happy International #WomenInScienceDay! To all young women & girls dreaming of a career in science - this is for you! 🤗 Keep going - your curiosity, determination, and brilliance will shape the future! ✨ 🔬 #IDWGS2025 #GirlsInSTEM

submitted 14 days ago • 1 comment

Now online in Cancer Discovery: LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma - by Eunae You, David Ting, and colleagues doi.org/10.1158/2159...

submitted 15 days ago • 0 comments

Remember that Europe (@ebi.embl.org) has mirrored all these services and they will keep on running. They look and feel a bit different but do the same thing. I think @ewanbirney.bsky.social should be able to confirm. www.europepmc.org www.ebi.ac.uk/jdispatcher/...

submitted 19 days ago • 9 comments

Now online in Cancer Discovery: High-Purity Circulating Tumor Cell RNA Sequencing Identifies #ProstateCancer Lineage Phenotypes Prognostic for Clinical Outcomes - by Marina Sharifi, Jamie Sperger, Shuang Zhao, Joshua Lang, and colleagues doi.org/10.1158/2159...

submitted 19 days ago • 0 comments

Thank you #AACR for your strong support of #cancer researchers and the people who do that work! www.aacr.org/about-the-aa...

submitted 21 days ago • 0 comments

Do you know Daisy Roulland-Dussoix? She is one of the discoverers of restriction enzymes, who’s findings paved the way for the development of recombinant DNA and cloning technologies. Accordingly, the finding was rewarded with a #NobelPrize. But the prize didn’t go to her. 🧵👇

submitted 24 days ago • 7 comments

Affected by #NIH and #NFS funding cuts? Considering a move abroad to escape? I haven't advertised this yet, but I have fresh funding for 2 senior #postdoc positions in #oxford. If you're into #Cancer #genomics and #epigenetics then get in touch. Please RT 🙏

submitted 25 days ago • 0 comments

Postdocs: University of Toronto (@uoft.bsky.social) has a fantastic #postdoc fellowship specifically for Black and Indigenous scholars worth $80K/year x 2 years. For more info see here: www.sgs.utoronto.ca/awards/provo....

submitted 26 days ago • 0 comments

Did anyone else got an 403 error trying to reach PubMed?

submitted 28 days ago • 2 comments

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events* *should be specific to gene regulation

submitted 42 days ago • 17 comments

Do you want to explore the #chromatin of an organism? Join our expert instructors at #LowInput25, and learn how to use low input techniques to support your #epigenomics research at the gene & genome-wide level ⏰Application deadline: 11 February 📎bit.ly/40fdETV #ChromatinSky @nmaziak.bsky.social

submitted 43 days ago • 0 comments

Hive-mind: what #epigenetics and #cancer #genomics conferences should I not miss this year?

submitted 41 days ago • 3 comments

We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements. www.genesdev.org/cgi/doi/10.1...

submitted 54 days ago • 2 comments

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/ www.encodeproject.org/single-cell/...

submitted 49 days ago • 6 comments

"these findings suggest L1 is a potent mutagenic force capable of driving genome evolution beyond simple insertions" 🚨

submitted 69 days ago • 0 comments

This is a beautiful piece on a sad day.

submitted 81 days ago • 1 comment

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

submitted 85 days ago • 4 comments

To give researchers a better view of the #cancer #genomics #wgs #wgts and clinical data held by (with patient consent) the Hartwig Medical Foundation we've made overviews of their (immuno)genomic landscapes of cancer types: www.hartwigmedicalfoundation.nl/en/data/vign...

submitted 84 days ago • 0 comments

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

submitted 85 days ago • 14 comments

Our new preprint is out - please share! We asked: How can we make CRISPR knockouts in vivo more efficient? And set up an assay that enables detection of CRISPR cutting with 100s-1000s of sgRNAs over entire chromosome arms in living animals. Grab a ☕ and let’s dive in. 🧵🧪 1/n #CRISPR #geneediting

submitted 85 days ago • 2 comments

Large crowds mobilising today to protest (we could not even fit in 3 different trains) in The Hague. The Dutch government wants to cut 1 billion euros to science and education. This policy will damage the country profoundly. Stop the budget cuts. Protect the future. @woinactie.bsky.social

submitted 92 days ago • 0 comments

Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms www.cell.com/immunity/ful...

submitted 95 days ago • 0 comments

www.nature.com/articles/s41... Single-molecule states link transcription factor binding to gene expression Deep insights into multiple facets of TF binding, accessibility & expression with biophysical models of single molecule data by Ben Doughty, Michaela Hinks, Bintu & Greenleaf labs

submitted 96 days ago • 0 comments

I just wrote an article (will post when out) describing the pre-vaccine era of Covid-19 for people with cancer. Up to 55% of people with Covid-19 who had blood cancer died from Covid (several studies) - average around 30%. Absolutely staggering loss. We forget so quickly.

submitted 96 days ago • 1 comment

So interesting: " Outliers for neoplasia prevalence include the common porpoise (<1.3%), the Rodrigues fruit bat (<1.6%), the black-footed penguin (<0.4%), ferrets (63%), and opossums (35%). " 🤯

submitted 98 days ago • 0 comments

Here is a thread showcasing my GitHub repositories: 1) Friends Don't Let Friends Make Bad Graphs. An opinionated essay on good and bad graphs. My popular one by a long shot with 6.4k stars and 248 forks. github.com/cxli233/Frie...

submitted 106 days ago • 10 comments