lloeff.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Nature research paper: Balanced plant helper NLR activation by a modified host protein complex https://go.nature.com/410prG6

submitted 9 days ago • 0 comments

#Argonautes2025 update ... it will happen this August (27-30) @imgprague.bsky.social. Our ITs are finishing and testing the website, the registration will open on March 1st. More info will be provided later (once all speakers reply to my e-mail, just saying, not pushing 😁). Poster announcement:

submitted 10 days ago • 1 comment

Very happy to have worked on the PARIS system in Paris in @dbikard.bsky.social lab in the vibrant @pasteur.fr Whereas most French academic structures "indirectely" implied that I'm "too old" to be hired, David did trust in my expertise and my ability to do good research. 👇

submitted 12 days ago • 1 comment

Nature research paper: Multi-interface licensing of protein import into a phage nucleus https://go.nature.com/3QdP5SJ

submitted 17 days ago • 0 comments

🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵

submitted 17 days ago • 4 comments

Excited to share that our paper is now published in Nature! In this study, we uncovered a grid-cell-based circuit in medial entorhinal cortex that probes the surrounding environment with theta-paced, sweeping spatial representations 🧵 www.nature.com/articles/s41...

submitted 19 days ago • 3 comments

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats Francois Rousset, Ilya Osterman and coauthors! www.science.org/doi/10.1126/...

submitted 24 days ago • 1 comment

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

submitted 24 days ago • 2 comments

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab! www.nature.com/articles/s41...

submitted 25 days ago • 4 comments

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

submitted 25 days ago • 3 comments

Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise https://go.nature.com/4hDtGhL

submitted 25 days ago • 6 comments

It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus rdcu.be/d7EsN

submitted 27 days ago • 4 comments

Exciting update on the mechanism of Kiwa! Congrats @fnobrega.bsky.social et al!

submitted 30 days ago • 1 comment

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! www.cell.com/cell/fulltex...

submitted 31 days ago • 6 comments

Beautiful use of AF to mine viral inhibitors of immune systems. Congrats @erezyirmiya.bsky.social @soreklab.bsky.social et al!!

submitted 31 days ago • 0 comments

Excited to share our work using machine learning to predict anti-phage defense systems! 1/n

submitted 45 days ago • 2 comments

What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...

submitted 45 days ago • 3 comments

🚨New review🚨 Evolution and ecology of anti-defence systems in phages and plasmids Link: www.cell.com/current-biol...

submitted 47 days ago • 1 comment

Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports... It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...

submitted 47 days ago • 4 comments

New paper alert! Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems www.cell.com/cell-reports... Together with @sumanthmutte.bsky.social, Pilar Bobadilla Ugarte, and Daan Swarts.

submitted 48 days ago • 1 comment

🦠Bacteria serve as an amazing reservoir of immune genes for eukaryotes but also of essential cellular functions! ⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons. Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ

submitted 48 days ago • 1 comment

Great stuff from a great friend @lloeff.bsky.social on the underlying mechanism of the Shedu anti-phage defense system. #HappyReading :)

submitted 54 days ago • 1 comment

The mechanism of the Shedu defense system revealed by Luuk Loeff, Martin Jinek and colleagues - it detects and destroys linear ends of phage DNA. A beautiful structural and mechanistic study 👇

submitted 54 days ago • 1 comment

Congrats!!

submitted 53 days ago • 1 comment

Check out a preprint from our lab! We've uncovered all possible speed imager sequences for DNA-PAINT. You can now do 10-plex imaging in just a few hours with simple Exchange-PAINT. 🚀📸 #DNApaint #SuperResolution www.biorxiv.org/content/10.1...

submitted 51 days ago • 0 comments

Discovery of a new family of viral proteins that sequester immune signaling molecules - by Renee Chang, Philip Kranzusch and co

submitted 54 days ago • 0 comments

www.sciencedirect.com/science/arti... Yet another phage defense system that detects free DNA ends and provides immunity without causing 'programmed cell death'.

submitted 53 days ago • 0 comments