lucasmassoth.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

This is a duodenal mass is a patient with inflammatory bowel disease presenting with 1 week of nausea and vomiting. What IHC do you want to order? #pathsky #pathology #histology

submitted 60 days ago • 1 comment

#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.

submitted 94 days ago • 1 comment

#PathSky I’m afraid I need 6 images for this one…Older adult with a large retroperitoneal mass. Most of it looks like this. Desmin (shown), SMA, and caldesmon are strongly positive.

submitted 95 days ago • 1 comment

Here is a bipartisan #pathology case. It's relevent to DVMs and MDs. Lots of red (at least pink) and blue, too. Rhinoscopy and nasal biopsy from a dog. What’s your diagnosis? It's a classic. #vetpath #pathsky #Mesomycetozoea #pathology #respiratorypathology #endoscopy #rhinoscopy

submitted 95 days ago • 7 comments

#PathSky. Mass next to knee, 27F. A hypocellular tumor with striking vascular changes, like we see in pleomorphic hyalinizing angiectatic tumor or schwannoma. But also some small fascicles of monomorphic spindled cells and a calcification. SS18::SSX fusion antibody +. Sneaky synovial sarcoma.

submitted 103 days ago • 6 comments

Now that I have a few followers, most of whom are pathologists, I thought I'd give you an unknown. This is small intestine from a dog. What's your diagnosis? Any rule-outs? Our Biopsy Conference participants had one principal rule-out with two alternates.

submitted 106 days ago • 2 comments

#PathSky Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/

submitted 107 days ago • 1 comment

This, as featured in my avi, was a cute little finding. Enterobius in a tubular adenoma #pathology #GIPath #histology #histopathology

submitted 113 days ago • 1 comment

A nasty testis in a teenager. Any guesses? #pathsky #gupath

submitted 107 days ago • 3 comments

Nodular lymphocyte predominant Hodgkin lymphoma exhibiting characteristic PD1+ T-cell rosettes around tumor cells #Pathsky #Pathology #Hemepath

submitted 107 days ago • 0 comments

I called this a tonsillar fibroma since I didn't know what else to call it, but it's a great section! Almost like the tonsil has its own uvula. #pathsky #pathology

submitted 108 days ago • 1 comment

#PathSky I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?

submitted 108 days ago • 1 comment

Acute promyelocytic leukemia, Giemsa stain #pathsky #medsky #pathology #oncology #hemepath

submitted 108 days ago • 1 comment

Hybrid tumor: Oncocytoma and Chromophobe Renal cell Carcinoma! #GUpathsky #pathsky #pathology #surgicalpathology #pathart #Nephsky

submitted 109 days ago • 2 comments

Ok, my third attempt at a first post. I like surgical pathology and sharing cases. New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet. pubmed.ncbi.nlm.nih.gov/38866368/ #PathSky

submitted 109 days ago • 7 comments

Patient with #CLL and geographic necrosis. What is dx? #pathsky #hemepathsky #hemesky #medsky

submitted 109 days ago • 2 comments

🔬Quiz yourself with a past #EmoryCoTW A bone marrow aspirate shows cytoplasmic vacuoles in myeloid and erythroid precursors (see images). Which nutrient deficiency should be considered? #PathSky #Pathology #PathResidents #MedSky #Path2Path #PathMatch25 #PathMatch2025

submitted 109 days ago • 2 comments

Granular cell tumor (GCT), tongue, H&Es, 10x and 40x & CD68 and S100, 20x: Large round to oval tumor cells with indistinct eosinophilic, granular cytoplasm - CD68, S100, and SOX10 positive! #pathology #pathsky #surgicalpathology #granularcelltumor #gct #headandneckpathology #pathart

submitted 109 days ago • 1 comment

Touch preparation of high-grade mullerian serous carcinoma presenting as a large abdominal mass, performed at the time of frozen section. Although not always additive, touch preparations can be a useful adjunct to evaluate tumor morphology intraoperatively #pathsky #medsky #pathology #gynpath

submitted 109 days ago • 1 comment

So glad you asked! To start, you can’t just train a set on randomly submitted diagnostic information. You need good curated information about the patients’ history. You need appropriate numbers of both positive and negative examples of all target conditions. 1/4 #pathsky #medsky

submitted 109 days ago • 6 comments

Amyloid! Everyone’s favourite exam question. Seen here in a bladder biopsy for investigation of haematuria. A not uncommon isolated finding in this location. Amorphous eosinophilic material in the lamina propria, in this case associated with vessel walls. #pathsky #pathresidents

submitted 109 days ago • 0 comments

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts www.nature.com/articles/s41...

submitted 110 days ago • 4 comments

A few years ago, I got temporarily stumped by the morphology of these circulating leukocytes... Any guesses what these cells are? What's the diagnosis? #hemepathsky #hemesky #pathsky #bloodsky #UMichPath

submitted 110 days ago • 3 comments

Microglandular adenosis (MGA), breast, H&E, 10x and 40x: A rare breast lesion! #pathology #pathsky #surgicalpathology #breastpathology #microglandularadenosis #MGA

submitted 111 days ago • 0 comments

‘Starry sky’ appearance of Burkitt lymphoma, here involving testicle #pathsky #medsky #pathology #hemepath

submitted 110 days ago • 1 comment

Interesting case of ANCA GN apparently triggered by COVID infection. Also showed concurrent membranous features with MPO+(IHC below) IgG (IF below) deposits as has been described: www.sciencedirect.com/science/arti.... #renalpath #nephrology #pathsky

submitted 112 days ago • 1 comment

Happy Friday everyone! Extranodal marginal zone lymphoma involving salivary gland, seen forming lymphoepithelial lesions #pathsky #medsky #pathology #hemepath #oncology

submitted 113 days ago • 0 comments

It’s almost Friday so here’s a case of metastatic papillary thyroid carcinoma that now shows anaplastic transformation. The late great Dr Livolsi and I did a study on such brain metastases detailing the histologic and molecular features ❤️🧠🔬 #pathsky pubmed.ncbi.nlm.nih.gov/36889238/

submitted 114 days ago • 1 comment

Endocervical adenocarcinoma in situ (AIS). While HPV16 is the most frequent subtype detected in AIS, it shows a stronger association with HPV18 relative to high grade squamous lesions. #pathsky #medsky #pathology #gynpath

submitted 114 days ago • 0 comments

Christening my timeline with some favorite images of pesky pathogens. Can anyone name the two different organisms pictured on each H&E stain of BAL fluid? (#2 is harder 🤭) #pathsky #IDsky

submitted 116 days ago • 4 comments

Intrauterine perivascular epithelioid tumor (PEComa) exhibiting HMB45 expression by IHC. This lesion was small and lacked atypia or mitotic activity, predicting benign behavior. #pathsky #medsky #pathology

submitted 116 days ago • 0 comments

Case of cellular rejection in a transplant kidney showing Bowman's capsulitis. Not a feature in Banff schema (yet); but has been associated with severe rejection. pubmed.ncbi.nlm.nih.gov/29501487/ #renalpath #nephrology #pathsky

submitted 116 days ago • 0 comments

Endometrial clear cell carcinoma exhibits architecture that ranges from papillary to tubulocystic to solid nests. Unlike its cervical counterpart, CCC of the uterine corpus shows no association with in utero exposure to diethylstilbestrol (DES) #pathsky #medsky #pathology #oncology

submitted 116 days ago • 0 comments

Myxopapillary ependymoma grossly has a characteristic sausage-shaped appearance. Commonly found associated with the filum terminale, it has a fibrillary glial appearance in a myxoid background. Though previously categorized as CNS WHO grade 1, it is now considered grade 2 #pathsky #medsky #neuropath

submitted 117 days ago • 0 comments

So-called ‘flame cells’ present in IgA plasma cell myeloma #pathsky #medsky #pathology #oncology

submitted 117 days ago • 1 comment