Ok, my third attempt at a first post. I like surgical pathology and sharing cases. New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet. pubmed.ncbi.nlm.nih.gov/38866368/ #PathSky - ThreadSky

folpe-mn-st.bsky.social • 109 days ago

Ok, my third attempt at a first post. I like surgical pathology and sharing cases.

New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet.

https://pubmed.ncbi.nlm.nih.gov/38866368/

#PathSky

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Comments

ravinratan.bsky.social•105 days ago

Really interesting. Recognize the morphological differences, but wonder if we are justified in treating as anything but Ewing until we understand the natural history.

folpe-mn-st.bsky.social•105 days ago

We wouldn’t have published it without follow up. @dehnercarina.bsky.social has a second paper as well.

https://pubmed.ncbi.nlm.nih.gov/39522640/

ravinratan.bsky.social•98 days ago

Thanks--it's a really interesting topic. I took care of a patient with what sounds like this entity a few years ago. Small primary skin tumor in a middle aged woman, couldn't call it Ewing until the translocation was identified.

ravinratan.bsky.social•98 days ago

At the time, this was the best reference I could find: https://pubmed.ncbi.nlm.nih.gov/22098102/ Some or most of these patients might have been regular Ewing--the metastatic risk is not 0, and most patients received chemo.
Dilemma remains whether or not we should deescalate treatment in these patients.

folpe-mn-st.bsky.social•97 days ago

Thx. If course there are true cutaneous Ewing sarcomas too. We also have a follow up paper by @dehnercarina.bsky.social a couple more “cutaneous Ewing” seem to be this instead.

https://pubmed.ncbi.nlm.nih.gov/39522640/

lucasmassoth.bsky.social•109 days ago

Nice case. Tell Petur Nielsen to make an account!

smlungpathguy.bsky.social•108 days ago

Very cool!

shounakgupta.bsky.social•108 days ago

Nice case!

drautopsy.bsky.social•109 days ago

Woah that’s pretty neat!

cpschukow.bsky.social•109 days ago

Great job on your post, Dr Folpe. Please keep it up. Your #BSTpath knowledge is much needed and well received here on #PathSky!

folpe-mn-st.bsky.social•109 days ago

Thanks. I wanted this to be in PathSky and I put in the hashtag at the end of my post. But I don’t think it worked. What have I done wrong?

cpschukow.bsky.social•109 days ago

Ahh I see. Actually you may have to be on the “PathSky” setting. See the attached photo. Including the hashtag is good though. Stay tuned- I’m planning on writing a how-to primer for navigating PathSky for #pathologists. #PathSky

nadianaumova.bsky.social•109 days ago

It is visible to n #PathSky

tosishe.bsky.social•108 days ago

😮 awesome case! Thank you for sharing)

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