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shounakgupta.bsky.social
5 posts 17 followers 16 following
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#PathSky Older adult with a large, prolapsing esophageal mass. An excellent example of a “giant fibrovascular polyp” of the esophagus. Except that essentially 100% of these turn out to be well-differentiated ( or less often dedifferentiated) liposarcomas. pubmed.ncbi.nlm.nih.gov/28984298/

submitted 44 days ago • 0 comments

Fun EM finding: crystalline proto-renin granules in a renin producing cell of the juxta glomerular apparatus. Important not to confuse this with some sort of pathologic crystal. #renalpath #nephsky #pathsky

submitted 61 days ago • 0 comments

Just learned about bluesky! For a first post, here is an image of ductal type prostate cancer. Diagnostic criteria can be controversial but common features are columnar cells and papillary structures. Typically considered grade 4. #GUpath

submitted 87 days ago • 2 comments

#slidearchiveseries SMARCB1 deficient renal medullary carcinoma #gupath #pathsky #pathoutpic 🩸 young pts with sickle cell trait 🔬 cribriform, reticular, nested growth 🎨 PAX8, broad spectrum CKs, CEA, p53 ⚠️ OCT3/4 ➕ (50%), pitfall with GCT 🔑 SMARCB1 / INI1 inactivation

submitted 87 days ago • 1 comment

#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.

submitted 95 days ago • 1 comment

#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.

submitted 107 days ago • 4 comments

Here is a snapshot of ongoing work to assess HRD status using a clinically validated CGP assay that was presented at AMP

submitted 104 days ago • 0 comments

#PathSky. As long as I’m sitting here in Sunday doing a frozen…. 73F, arm. Foamy cell angiosarcoma- a very difficult, very rare subtype. pubmed.ncbi.nlm.nih.gov/20175826/

submitted 105 days ago • 0 comments

I am happy to present the results of ongoing work focused on optimizing MSI assessment using smaller targeted NGS panels that was recently presented at AMP

submitted 104 days ago • 0 comments

A stunning image for #FoxOfTheDay shared by @Fox.Family._ on Instagram.

submitted 108 days ago • 244 comments

#PathSky Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/

submitted 108 days ago • 1 comment