manolis-maragkakis.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Latest work from our next door neighbors! #RNAsky #RNAbiology

submitted 13 days ago • 0 comments

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78) I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine 1/n

submitted 10 days ago • 8 comments

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

submitted 67 days ago • 4 comments

If you want to hear me rant about #RNA, #stress, #aging, #senescence come join me at the RNA collaborative seminar tomorrow Wed 4pm (EST) #RNAsociety #RNAsky #RNAbiology

submitted 70 days ago • 0 comments

circRNAs as tools for gene silencing, similar to microRNA-mediated gene silencing. Do we also need circRNA target prediction software? Circular RNAs trigger nonsense-mediated mRNA decay: Molecular Cell

submitted 75 days ago • 0 comments

SERVICE UPDATE We normally don't ask you to "share like and subscribe" but please distribute this. You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research. #AcademicSky #Medsky #HigherEd

submitted 76 days ago • 9 comments

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

submitted 76 days ago • 11 comments

Not looking to start a debate on #nextflow vs. #snakemake, but curious about their ease of adoption in a typical lab setting with ~4-year PhD/postdoc turnover. How do you feel newcomers adapt to each? Would you recommend one for easier onboarding? Feedback appreciated! #genomics #bioinformatics

submitted 77 days ago • 4 comments

How can physics define universal laws for computation, from cells and chips to brains? In this @pnas.org Perspective, led by @sfiscience.bsky.social David Wolpert and Jan Korbel, they suggest how Stochastic Thermodynamics can provide the proper framework pnas.org/doi/epub/10....

submitted 80 days ago • 0 comments

🎄🧪 Racing to submit your manuscript before the holidays? Check out our ShinyApp for editorial insights on publishers & journals—submission-to-acceptance times and more! Based on data from: doi.org/10.1162/qss_... Check the app here 👉 pagoba.shinyapps.io/strain_explo... #AcademicSky #Science

submitted 80 days ago • 1 comment

G3BP1 promotes intermolecular RNA-RNA interactions during #RNA condensation #RNAsky www.cell.com/molecular-ce...

submitted 83 days ago • 0 comments

A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging www.nature.com/articles/s43...

submitted 83 days ago • 0 comments

Tracking transcription–translation coupling in real time doi.org/10.1038/s415...

submitted 83 days ago • 0 comments

#RNAsky #RNAbiology

submitted 83 days ago • 0 comments

Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts www.nature.com/articles/s41...

submitted 85 days ago • 3 comments

A panoramic view of cell population dynamics in mammalian aging www.science.org/doi/10.1126/...

submitted 89 days ago • 0 comments

Tips for scientist that are joining bsky. Super helpful to fill out your profile before you follow anyone. Listing interests and what you do helps a lot. At least one post, also helps to set the tone. Then starter packs will help you find accounts. Also ask to be added when within your expertise.

submitted 90 days ago • 0 comments

img: Sci-Illustrate.com. Dichotomy of stress response in senescent and cycling cells. Low #ribosome content in #senescence (right) reduces upstream ORF bypass (gold line) on ATF4 #RNA, despite high eIF2α-P (green). ➡️ Prevents #ISR activation and remodels the secretome (red). #aging #cancer #GeroSky

submitted 91 days ago • 0 comments

I hope you'll find this helpful in building our community around #CancerandAging go.bsky.app/AfLLSfN

submitted 92 days ago • 3 comments

Mitochondrial fatty acid oxidation drives senescence www.science.org/doi/10.1126/...

submitted 92 days ago • 0 comments

Very nice work!

submitted 92 days ago • 0 comments

Nanopore RNA-seq across six tissues x six species (five mammals + chicken) reveals conserved alt splicing and m6a mods

submitted 93 days ago • 0 comments

Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added! go.bsky.app/5UXXaDA

submitted 94 days ago • 47 comments

🚨 Update for #RNA science fans: I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far: 1. General RNA biology #1 go.bsky.app/RN6HnZp

submitted 97 days ago • 30 comments

Among so many amazing starter packs, but none focused on RNA splicing - so we made one! Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions! go.bsky.app/TigRnmC #rnasplicing

submitted 100 days ago • 12 comments

Biomolecular condensate starter pack! Trying to compile & to bring together biomolecular condensate enthusiasts & critics! Please join this non-exhaustive (sorry!) collection & just ping me for addition. #condensates, #phaseseparation, #granules, #IDPs go.bsky.app/NFqmffa

submitted 100 days ago • 18 comments

m6A sites in the coding region trigger translation-dependent mRNA decay: Molecular Cell www.cell.com/molecular-ce...

submitted 93 days ago • 1 comment

I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that have been floating around. It is important to understand how this agency actually functions and point criticism at the right problems. A short 🧵:

submitted 93 days ago • 7 comments

releasing a new Comp Bio + AI + ML starter pack 🧬 🖥️ 🧑🏾‍🔬 #compbio #AI #ML #singlecell #Bio #computational #biologie #bioinformatics go.bsky.app/Gia7iMf

submitted 98 days ago • 2 comments

Here’s the updated Computational Biology Starter Pack! Let me know if you'd like to be included. go.bsky.app/QVPoZXp

submitted 93 days ago • 82 comments