manuelthery.bsky.social
cytoskeleton self-organization / shape, patterns and symmetry / minimal and artificial cells / biophysics teacher @ ESPCI ParisTech
www.cytomorpholab.com
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Yes images are beautiful but the conclusions are not so different from the work of @binyammogessie.bsky.social and @schuhlab.bsky.social and @grosselab.bsky.social and many observations (in the version I reviewed for Nature) were overinterpretated.
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Although most will go to EMBO 8148 euros with the tax is crazy expensive !
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aaaah ok ! Thanks Bernd for clarifying this. I feel better 😮💨
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we do it regularly:
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
but does the money actually go to the SBCF or to Wiley ?
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the rotation comes from the fact that MT are not 1D. They have a width. motors walk on the sides, hence the torque.
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Let's allow the MT to move now. It moves and propagates its pattern of motors.
Since there are more blue motors (minus end directed), the MT is moving and ... can now encounter another MT !
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MT efforts to organize space is more clear with more motors and less diffusion. Now you see the point: MTs generate local accumulation of motors, which push/pull the microtubule accordingly. MTs act on motors which act on MTs. The stage is set for something to happen.
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IRL MTs propelled by single motores do turn, not as much as on the video but they do. flexibility could be a reason indeed.
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good question! i will ask Florian if the position of the motors when they contact the microtubule matters. the side steps along the microtubules, which confer rotation in real experiments, are not considered here.
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It becomes even more exciting when the transient imbalance of the two opposite motors can propel the microtubule accordingly.
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Right! but consider also that the boundary condition can be another microtubule!
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(2/3) 🎥 Ebenfalls ausgezeichnet: Lucien Hinderling, Doktorand am Institut für #Zellbiologie – mit einem faszinierenden Video-Loop zur Bewegung von #Krebszellen.
@lhinderling.bsky.social
@olivierpertz.bsky.social
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under the control of ... microtubules ❤️ #CytoskeletonWars
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among all the bottom projections, which one is "the" axon? many look pretty active as compared to the somatic ones.
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cant wait
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congratulations Jorge. I look forward to celebrate this with neither a single great or two good bottles but two great bottles of wine!
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My highlight of the two days, with putting my hand on AI, was the Schmitt et al paper by Gardel Oakes and Vitelli labs on the investigation of the AI algorythm predicting traction forces from zyxin field
www.cell.com/cell/pdf/S00...